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    當前位置 : Millipore >>> Millipore/MT17MAG47K-PX25 | MILLIPLEX MAP Mouse TH17 Magnetic Bead Panel - Premixed 25 plex - Immunology
    Millipore/MT17MAG47K-PX25 | MILLIPLEX <small>MAP</small> Mouse TH17 Magnetic Bead Panel - Premixed 25 plex - Immunology
    • Millipore/MT17MAG47K-PX25 | MILLIPLEX <small>MAP</small> Mouse TH17 Magnetic Bead Panel - Premixed 25 plex - Immunology

    Millipore/MT17MAG47K-PX25 | MILLIPLEX MAP Mouse TH17 Magnetic Bead Panel - Premixed 25 plex - Immunology

    價格: ¥46716.00 市場價: 77860.00

    貨號: MT17MAG47K-PX25
    品牌: Millipore
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      • Description
        CatalogueNumberMT17MAG47K-PX25
        TradeName
        • MILLIPLEX
        DescriptionMILLIPLEXMAPMouseTH17MagneticBeadPanel-Premixed25plex-ImmunologyMultiplexAssay
        OverviewTheMILLIPLEXMAPMouseTh17MagneticBeadpanelenablesyoutofocusonthetherapeuticpotentialofthemodulationofCD4T-helpercellcytokines.CoupledwiththeLuminex?xMAP?platforminamagneticbeadformat,youreceivetheadvantageofidealspeedandsensitivity,allowingquantitativemultiplexdetectionofdozensofanalytessimultaneously,whichcandramaticallyimproveproductivity.
        BackgroundInformationCD4T-helpercellsaremajorplayersinadaptiveimmunity.Basedontheirexpressionprofileoftranscriptionfactorsandsecretedcytokines,thesecellsaredividedintothemajorsubsetsTh1,Th2,Th17andTregulatory(Treg)cells.Th1cells,inducedbyIL-12andenhancedbyIFN?,secreteIFN?thatactivatesmacrophages.InducedbyIL-4,Th2cellsprimarilyproduceIL-4,IL-5,IL-13,IL-25andIL-17E,playingaroleinallergy.Tregcells,inducedbyTGFβ,producetheanti-inflammatorycytokinesIL-10andTGFβandfunctiontocontrolT-cellresponsestopreventautoimmunereactions.Th17cells,amorerecentlydiscoveredsubsetcharacterizedbytheproductionofIL-17,areinducedbyTGFβcombinedwithIL-23andIL-1βinhumans,andTGFβ,IL-6andIL-21inmice.ActivatedTh17cellssecreteIL-17A,IL-17F,IL-21,IL-22andTNFαtopromotetissueinflammation.

        Th17cellsareinvolvedintheclearanceofextracellularbacteriaandfungi.TheyareabundantintheintestinallaminapropriaandfunctionasabarrieragainstinvADIngpathogens.ExcessiveamountsofTh17cellshavebeenimplicatedinthepathogenesisofseveralautoimmunediseases,includingmultiplesclerosis,psoriasis,juvenilediabetes,rheumatoidarthritis,Crohn"sdiseaseandautoimmuneuveitis.InadditionTh17cellsplayanimportantroleintumordevelopment,progressionandmetastasis,potentiallyinbothpromotingandinhibitingtumorgrowth.
        ProductInformation
        DetectionmethodLuminexxMAP
        ConfigurationPremixed
        Precision,%
        • Inter-assay:<>
        • Intra-assay:<>
        PanelTypeMAGNETICCytokines/Chemokines
        StorageandShippingInformation
        StorageConditionsRecommendedstorageforkitcomponentsis2-8°C.
        Applications
        ApplicationSimultaneouslyanalyzemultipleTh17cytokineandchemokinebioMarkerswiththeTh17Bead-BasedMultiplexAssaysusingtheLuminextechnology,inhumanserum,plasmaandcellculturesamples.
        KeyApplications
        • Multiplexing
        ApplicationNotes?Thisisatwo-hourorovernightincubationassayrequiring25μLofneatplasmaorserum,or25μLcellculturesupernatantperwell.
        ?ThiskitmaybeusedfortheanalysisofalloranycombinationoftheTh17panelanalytesinserum,plasmaortissue/celllysateandculturesupernatant
        BIOLOGicalInformation
        SpecificityCross-reactivitybetweentheantibodiesandanyoftheotheranalytesinthispanelisnon-detectableornegligIBLe.
        SpeciesReactivity
        • Mouse
        AnalytesAvailable
        • CD40Ligand
        • GM-CSF
        • IFN-γ
        • IL-1β
        • IL-2
        • IL-4
        • IL-5
        • IL-6
        • IL-10
        • IL-12(p70)
        • IL-13
        • IL-15
        • IL-17A
        • IL-17E/IL-25
        • IL-17F
        • IL-21
        • IL-22
        • IL-23
        • IL-27
        • IL-28B
        • IL-31
        • IL-33
        • MIP-3α/CCL20
        • TNF-α
        • TNFβ
        CrossReactivityTherewasnoorminimumcross-reactivitybetweentheantibodiesandanyotheranalytesinthepanel(seedetailsinassayprotocol).
        Accuracy
        • 85-110%
        PhysicochemicalInformation
        Sensitivity
        • Refertokitprotocolforsensitivitiesofindividualbiomarkers.
        LinearityofDilution1:4111.0%1:8113.1%
        StandardCurveRange
        • CD40LIL-31&MIP-3α:49–50,000pg/mL
        • GM-CSF&IL-15:34–35,000pg/mL
        • IFNγ&IL-6:7.8–8,000pg/mL
        • IL-1β:15–15,000pg/mL
        • IL-2:6.9–6,000pg/mL
        • IL-4:1.5–1,500pg/mL
        • IL-5:4.9–5,000pg/mL
        • IL-10,IL-12(p70),&IL-21:20–20,000pg/mL
        • IL-13&IL-17A:39–40,000pg/mL
        • IL-17E/IL-25:586–600,000pg/mL
        • IL-17F:10–10,000pg/mL
        • IL-22:2.4–2,500pg/mL
        • IL-23:342-350,000pg/mL
        • IL-27:879–900,000pg/mL
        • IL-28B:127–130,000pg/mL
        • IL-33:78–80,000pg/mL
        • TNFβ:488–500,000pg/mL
        • TNFα:3.4–3,500pg/mL
        Dimensions
        MaterialsInformation
        MaterialsInformation
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