| Immunogen | SKW3cells |
| Clone | CBR-IC31 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Isotype | IgG1κ |
| SpeciesReactivity | |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Theproteinencodedbythisgeneisamemberoftheintercellularadhesionmolecule(ICAM)family.AllICAMproteinsaretypeItransmembraneglycoproteins,contain2-9immunoglobulin-likeC2-typedomains,andbindtotheleukocyteadhesionLFA-1protein.ThisproteinisconstitutivelyandabundantlyexpressedbyallleucocytesandmaybethemostimportantligandforLFA-1intheinitiationoftheimmuneresponse.Itfunctionsnotonlyasanadhesionmolecule,butalsoasapotentsignallingmolecule.[providedbyRefSeq]. |
| GeneSymbol | - ICAM-3
- ICAM-R
- CDW50
- CD50
- CDw50
|
| PurificationMethod | ProteinGPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:ICAMproteinsareligandsfortheleukocyteadhesionproteinLFA-1(integrinalpha-L/beta-2).ICAM3isalsoaligandforintegrinalpha-D/beta-2.
SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein.
PTM:Uponstimulationbyaphysiologicstimulibecomesrapidlyandtransientlyphosphorylatedonserineresidues.
N-glycosylated;glycansconsistofamixtureoftri-andtetra-antennarycomplex-typechainsandhigh-mannosechains.
SEQUENCESIMILARITIES:Belongstotheimmunoglobulinsuperfamily.ICAMfamily.
Contains5Ig-likeC2-type(immunoglobulin-like)domains. |
| MolecularWeight | 59kDacalculated |