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Millipore/MABT26 | Anti-E-cadherin Antibody, clone DECMA-1/MABT26/100 µg

價格: ￥3948.00 市場價: 6580.00

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貨號: MABT26

品牌: Millipore

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Description
CatalogueNumber	MABT26
Description	Anti-E-cadherinAntibody,cloneDECMA-1
AlternateNames	CAM120/80 CD324antigen Cadherin1,E-cadherin(epithelial) cadherin1,type1 cadherin1,type1,E-cadherin(epithelial) calcium-dependentadhesionprotein,epithelial cell-CAM120/80
BackgroundInformation	CadherinsareafamilyoftransmembraneglycoproteinsinvolvedinCa2+-dependentcelltocellinteractions.Themembersofthefamilyaredifferentiallyexpressedinvarioustissuesandfunctioninthemaintenanceoftissueintegrity,morphogenesis,andmigration.CadherinsaredividedintotypeIandtypeIIsubgroups.TypeIcadherinsincludeepithelialcadherin(E-cadherin),neuralcadherin(N-cadherin),placentalcadherin(P-cadherin)andretinalcadherin(R-cadherin).TypeIIincludekidneycadherin(K-cadherin)andosteoblastcadherin(OB-cadherin).OneofthebestcharacterizedcadherinsisE-cadherin(epithelialcadherinorcadherin-1).Itconsistsofcalcium-bindingextracellulardomainsresponsIBLeforinteractionswithotherE-cadherinmoleculesonneighboringcellsandinteractionwithintegrinalphaEbeta7.ThecytoplasmicdomainofE-cadherinislinkedtotheactinCytoskeletonthroughcytoplasmiccateninproteins,thusestablishingacomplexlocalizedtoadherensjunctions.Incarcinomas,E-cadherinisfrequentlydownregulated,consistentwithitsfunctionofaninvasionsuppressorinnormalepithelia.

ProductInformation
Format	Purified
Control	A431celllysate
Presentation	PurifiedratmonoclonalIgG1κinbuffercontainingPBSwithoutpreservative.

StorageandShippingInformation
StorageConditions	Stablefor1yearat-20°Cfromdateofreceipt. HandlingRecommendations:Uponreceiptandpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.

Applications
Application	ThisAnti-E-cadherinAntibody,cloneDECMA-1isvalidatedforuseinWB,IH,IC,IP,FC,FUNCforthedetectionofE-cadherin.
KeyApplications	WesternBlotting Immunohistochemistry Immunocytochemistry Immunoprecipitation FlowCytometry AffectsFunction
ApplicationNotes	ImmunohistochemistryAnalysis:1:300dilutionofthisantibodyhasbeenshowntodetectE-cadherininmouseGItracttissue. Inhibition:Apreviouslotwasusedbyanindependentlaboratoryininhibionstudies,blockingE-cadherinassociatedcelladhesion.(Vestweber,1985) FlowCytometryAnalysis:Apreviouslotwasusedbyanindependentlaboratoryinflowcytometryapplications.(Tang,1994)

BIOLOGicalInformation
Immunogen	MouseembryonalcarcinomacelllinePCC4
Clone	Decma-1
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Rat
Isotype	IgG1κ
SpeciesReactivity	Human Mouse
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NP_033994
GeneSymbol	Arc-1 CD324 CDHE Cadherin-1 E-cadherin ECAD LCAM UVO Uvomorulin uvomorulin
PurificationMethod	ProteinG
UniProtNumber	P09803
UniProtSummary	FUNCTION:Cadherinsarecalcium-dependentcelladhesionproteins.Theypreferentiallyinteractwiththemselvesinahomophilicmannerinconnectingcells;cadherinsmaythuscontributetothesortingofheterogeneouscelltypes.CDH1isinvolvedinmechanismsregulatingcell-celladhesions,mobilityandproliferationofepithelialcells.Hasapotentinvasivesuppressorrole.Itisaligandforintegrinalpha-E/beta-7(bysimilarity). E-Cad/CTF2promotesnon-amyloidogenicdegradationofAbetaprecursors.HasastronginhibitoryeffectonAPPC99andC83production(bysimilarity). SUBUNITSTRUCTURE:Homodimer;disulfide-linked.Interactsdirectly,viathecytoplasmicdomain,withCTNNB1orJUPtoformthePSEN1/cadherin/cateninadhesioncomplexwhichconnectstotheactinskeletonthroughtheactinbindingofalpha-catenin.InteractionwithPSEN1,cleavesCDH1resultinginthedisassociationofcadherin-basedadherensjunctions(CAJs).InteractswithAJAP1,CTNND1andDLGAP5(bysimilarity). SUBCELLULARLOCATION:Celljunction.Cellmembrane;Single-passtypeImembraneprotein.Note:ColocalizeswithDLGAP5atsitesofcell-cellcontactinintestinalepithelialcells.AnchoredtoactinMICROFILamentsthroughassociationwithalpha-,beta-andgamma-catenin.Sequentialproteolysisinducedbyapoptosisorcalciuminflux,resultsintranslocationfromsitesofcell-cellcontacttothecytoplasm(bysimilarity). TISSUESPECIFICTY:Non-neuralepithelialtissues. DEVELOPMENTALSTAGE:Inthetestis,expressionishighestinfetalgonad,thendecreases5-foldinnewborn.Detectablein7-day-oldbutnotin21-day-oldoradult. SEQUENCESIMILARITIES:Contains5cadherindomains.
MolecularWeight	~106kDaobservedMW.

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Millipore/MABT26 | Anti-E-cadherin Antibody, clone DECMA-1/MABT26/100 µg

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