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    當前位置 : Millipore >>> Millipore/MABT149 | Anti-CD11b/ITAM Antibody, clone EP1345Y, rabbit monoclonal/MABT149/100 µL
    Millipore/MABT149 | Anti-CD11b/ITAM Antibody, clone EP1345Y, rabbit monoclonal/MABT149/100 µL
    • Millipore/MABT149 | Anti-CD11b/ITAM Antibody, clone EP1345Y, rabbit monoclonal/MABT149/100 µL

    Millipore/MABT149 | Anti-CD11b/ITAM Antibody, clone EP1345Y, rabbit monoclonal/MABT149/100 µL

    價格: 試用 市場價: 0.00

    貨號: MABT149
    品牌: Millipore
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      • Description
        CatalogueNumberMABT149
        DescriptionAnti-CD11b/ITAMAntibody,cloneEP1345Y,rabbitmonoclonal
        AlternateNames
        • integrin,alphaM(complementcomponent3receptor3subunit)
        • CellsurfaceglycoproteinMAC-1subunitalpha
        • LeukocyteadhesionreceptorMO1
        • CR-3alphachain
        • CD11antigen-likefamilymemberB
        • integrin,alphaM(complementcomponentreceptor3,alpha
        • alsoknownasCD11b
          (p170),macrophageantigenalphapolypeptide)
        • macrophageantigenalphapolypeptide
        • neutrophiladherencereceptoralpha-Msubunit
        • integrinalpha-M
        • antigenCD11b(p170)
        • CD11bantigen
        • Neutrophiladherencereceptor
        BackgroundInformationIntegrinalpha-M(ITAM,ITGAM,CD11b,MAC-1alphasubunit,CR3alphachain)isthealphasubunitofITAM/beta-2complex(CD11b/CD18,Mac-1),aleukocyteadhesionheterodimericglycoprotein(1).ITAMbelongstointegrinalphachainfamilyanditispredominatelypresentedinhumanmyeloidcells,NK1cells,monocytes,andgranulocytes.ITAM/beta-2complexisareceptorforfibrinogen(bindingtoP1andP1peptidesofgammachain),factorX,andICAM1.ITAM/beta-2isimplicatedinadhesiveinteractionsofmonocytes,macrophages,andgranulocytes.Itisalsolinkedtomediationofcomplement-coatedparticleuptake(2).
        ProductInformation
        FormatDilutedCultureSupernatant
        Control
        • TF-1celllysate
        PresentationRabbitMonoclonalinbuffercontaining50mMTris-Glycine(pH7.4),0.15MNaClcontaining40%Glycerol,0.01%sodiumazideand0.05%BSA.
        StorageandShippingInformation
        StorageConditionsStablefor1yearat-20oCfromdateofreceipt.HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
        Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.
        Applications
        ApplicationPleasenotethatthisproductwillnotbeavailableforsaleafterMarch15,2015.Pleaseselectoneoftheotherantibodiesagainstthistarget.DetectCD11b/ITAMusingthisAnti-CD11b/ITAMAntibody,cloneEP1345Y,RabbitvalidatedforuseinWB,IC,IH(P),IP,FC.
        KeyApplications
        • WesternBlotting
        • Immunocytochemistry
        • Immunohistochemistry(Paraffin)
        • Immunoprecipitation
        • FlowCytometry
        ApplicationNotesImmunohistochemistryAnalysis:1:100-1:250dilutionfromarepresentativelotdetectedCD11b/ITAMinhumanspleentissue.
        ImmunocytochemistryAnalysis:1:100-1:250dilutionfromarepresentativelotwasusedinIC.
        ImmunoprecipitationAnalysis:1:80dilutionfromarepresentativelotwasusedinIP.
        FlowCytometryAnalysis:1:20dilutionfromarepresentativelotwasusedinFC.
        BIOLOGicalInformation
        ImmunogenSyntheticpeptidecorrespondingtohumanCD11b/ITAMattheC-terminus.
        EpitopeC-terminus
        CloneEP1345Y
        HostRabbit
        IsotypeIgG
        SpeciesReactivity
        • Human
        AntibodyTypeMonoclonalAntibody
        EntrezGeneNumber
        GeneSymbol
        • CD11B
        • CR3A
        • MAC-1
        • MAC1A
        • SLEB6
        • CD11b
        • MO1A
        • MGC117044
        PurificationMethodUnpurified
        UniProtNumber
        UniProtSummaryFUNCTION:Integrinalpha-M/beta-2isimplicatedinvariousadhesiveinteractionsofmonocytes,macrophagesandgranulocytesaswellasinmediatingtheuptakeofcomplement-coatedparticles.ItisidenticalwithCR-3,thereceptorfortheiC3bfragmentofthethirdcomplementcomponent.ItprobablyrecognizestheR-G-DpeptideinC3b.Integrinalpha-M/beta-2isalsoareceptorforfibrinogen,factorXandICAM1.ItrecognizesP1andP2peptidesoffibrinogengammachain.
        SUBUNITSTRUCTURE:Heterodimerofanalphaandabetasubunit.Alpha-Massociateswithbeta-2.
        SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein.
        TISSUESPECIFICITY:Predominantlyexpressedinmonocytesandgranulocytes.
        DOMAIN:TheintegrinI-domain(insert)isaVWFAdomain.IntegrinswithI-domainsdonotundergoproteasecleavage.
        INVOLVEMENTINDISEASE:GeneticvariationsinITGAMhasbeenassociatedwithsusceptibilitytosystemiclupuserythematosustype6(SLEB6)[MIM:609939].Systemiclupuserythematosus(SLE)isachronic,inflammatoryandoftenfebrilemultisystemicdisorderofconnectivetissue.Itaffectsprincipallytheskin,joints,kidneysandSEROsalmembranes.Itisthoughttorepresentafailureoftheregulatorymechanismsoftheautoimmunesystem.
        SEQUENCESIMILARITIES:Belongstotheintegrinalphachainfamily.
        Contains7FG-GAPrepeats.
        Contains1VWFAdomain.
        MolecularWeight~170kDaobserved
        PhysicochemicalInformation
        Dimensions
        MaterialsInformation
        MaterialsInformation
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