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    當前位置 : Millipore >>> Millipore/MABN50 | Anti-Olig2 Antibody, clone 211F1.1/MABN50/100 µg
    Millipore/MABN50 | Anti-Olig2 Antibody, clone 211F1.1/MABN50/100 µg
    • Millipore/MABN50 | Anti-Olig2 Antibody, clone 211F1.1/MABN50/100 µg

    Millipore/MABN50 | Anti-Olig2 Antibody, clone 211F1.1/MABN50/100 µg

    價格: ¥4440.00 市場價: 7400.00

    貨號: MABN50
    品牌: Millipore
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      • Description
        CatalogueNumberMABN50
        DescriptionAnti-Olig2Antibody,clone211F1.1
        AlternateNames
        • oligodendrocytelineagetranscriptionfactor2
        • oligodendrocyte-specificbHLHtranscriptionfactor2
        • humanproteinkinaseC-bindingproteinRACK17
        • ProteinkinaseC-bindingprotein2
        • proteinkinaseCbindingprotein2
        • ClassBbasichelix-loop-helixprotein1
        • ProteinkinaseC-bindingproteinRACK17
        • basicdomain,helix-loop-helixprotein,classB,1
        BackgroundInformationOligodendrocytelineagetranscriptionfactor2(Olig2)isaproteinbelongingtogroupAoftheOLIGfamilyofbasichelix-loop-helixtranscriptionfactors(bHLH).bHLHproteinsaredividedinto6groups(A-F),andcharacterizedbytheirbiochemicalpropertiesandstructure.Olig2isclassifiedasgroupAduetoitsABIlitytoformheterodimerswithotherbHLHproteinsandbindingtotheEbox.Olig2hasacrucialroleduringdevelopmentinspecifyingthefinallocationofmotorneuronsandoligodendrocytesinthespinalcord,alongwiththedevelopmentwithinthehindbrainofsomaticmotorneurons.Olig2expressionisobservedwithinoligodendrocytesandindevelopingastrocytes.RecentstudieshaveshownstrongexpressionofOlig2inhumanoligodendrogliomas,primarytumorswithinthecentralnervoussystem,andmoderateexpressioninastrocytomas.TheseobservationshaveledtotheproposalofOlig2havingpotentialasanoligodendrogliomadiagnosticMarker.
        ProductInformation
        FormatPurified
        Control
        • Mousebrainlysate
        PresentationPurifiedmousemonoclonalIgG2aκinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide.
        StorageandShippingInformation
        StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
        Applications
        ApplicationDetectOlig2usingthisAnti-Olig2Antibody,clone211F1.1validatedforuseinWB,IC,IH&IP.
        KeyApplications
        • WesternBlotting
        • Immunocytochemistry
        • Immunohistochemistry
        • Immunoprecipitation
        ApplicationNotesImmunohistochemistryAnalysis:ThisantibodyhasbeenshowntodetectOlig2incoronalbraintissueasreportedbyanindependentlaboratory(Cai,J.,etal.(2007).Development.134:1887-1899).

        ImmunocytochemistryAnalysis:ThisantibodyhasbeenshowntodetectOlig2,asreportedbyanindependentlaboratory(Lee,S.K.,etal.(1995).Genes&Dev.19:282-294).

        ImmunoprecipitationAnalysis:ThisantibodyhasbeenshowntodetectOlig2,asreportedbyanindependentlaboratory(Lee,S.K.,etal.(1995).Genes&Dev.19:282-294).
        BIOLOGicalInformation
        ImmunogenRecombinantproteincorrespondingtohumanOlig2.
        EpitopeUnknown
        Clone211F1.1
        ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
        HostMouse
        SpecificityThisantibodyrecognizesOlig2.
        IsotypeIgG2aκ
        SpeciesReactivity
        • Mouse
        • Human
        • Rat
        SpeciesReactivityNoteDemonstratedtoreactwithmouse.Predictedtoreactwithhumanandratbasedon100%sequencehomology.
        AntibodyTypeMonoclonalAntibody
        EntrezGeneNumber
        GeneSymbol
        • OLIG2
        • OLIGO2
        • RACK17
        • PRKCBP2
        • Oligo2
        PurificationMethodProteinGPurified
        UniProtNumber
        UniProtSummaryFUNCTION:Requiredforoligodendrocyteandmotorneuronspecificationinthespinalcord,aswellasforthedevelopmentofsomaticmotorneuronsinthehindbrain.CooperateswithOLIG1toestablishthepMNdomainoftheembryonicneuraltube.AntagoNISTofV2interneuronandofNKX2-2-inducedV3interneurondevelopment(Bysimilarity).

        SIZE:323aminoacids;32385Da

        SUBUNIT:InteractswithNKX2-2(Bysimilarity).

        SUBCELLULARLOCATION:Nucleus(Bysimilarity).Cytoplasm(Bysimilarity).Note=TheNLScontainedinthebHLHdomaincouldbemaskedinthenativeformandtranslocationtothenucleuscouldbemediatedbyinteractioneitherwithclassEbHLHpartnerproteinorwithNKX2-2(Bysimilarity).

        TISSUESPECIFICITY:Expressedinthebrain,inoligodendrocytes.Stronglyexpressedinoligodendrogliomas,whileexpressionisweaktomoderateinastrocytomas.Expressioninglioblastomashighlyvariable.

        DOMAIN:ThebHLHisessentialforinteractionwithNKX2-2(Bysimilarity).DISEASE:SwissProt:Q13516#AchromosomalaberrationinvolvingOLIG2maybeacauseofaformofT-cellacutelymphoblasticleukemia(T-ALL).Translocationt(14;21)(q11.2;q22)withTCRA.

        SIMILARITY:Contains1basichelix-loop-helix(bHLH)domain.
        MolecularWeight~37kDaobserved
        PhysicochemicalInformation
        Dimensions
        MaterialsInformation
        MaterialsInformation
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