| Immunogen | Purifiedhuman-fibronectinfromamnionliquid. | 
| Epitope | cellattachmentfragment | 
| Clone | 3E3 | 
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. | 
| Host | Mouse | 
| Specificity | Theantibodyreactswithhumanfibronectinandwithapepticfragment(11.5kD)fromhumanfibronectin(Pierschbackeretal.,1981)comprimisingthecellattachmentsite(Pierschbackeretal.,1981;Pierschabackeretal.,1983,1984;Haymanetal.,1985;Ruoslahtietal.,1986;Hynes,1985).Itinhibitstheattachmentofnormalratkidneycellstohumanfironectincoatedplasticsurface(Pierschbackeretal.,1981).BindingoftheantibodytofibronectincannotbeinhibitedbycelladhesionpeptidesfromfibronectinhavingthesequenceArg-Gly-AspofGly-Arg-Gly-Asp-Ser(Pierschabackeretal.,1984;Haymanetal.,1985;Ruoslahtietal.,1986). | 
| Isotype | IgG1 | 
| SpeciesReactivity |  | 
| AntibodyType | MonoclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | Thisgeneencodesfibronectin,aglycoproteinpresentinasolubledimericforminplasma,andinadimericormultimericformatthecellsurfaceandinextracellularmatrix.Fibronectinisinvolvedincelladhesionandmigrationprocessesincludingembryogenesis,woundhealing,bloodcoagulation,hostdefense,andmetastasis.Thegenehasthreeregionssubjecttoalternativesplicing,withthepotentialtoproduce20differenttranscriptvariants.However,thefull-lengthnatureofsomevariantshasnotbeendetermined. | 
| GeneSymbol | - FN1
 - DKFZp686H0342
 - DKFZp686I1370
 - MSF
 - CIG
 - LETS
 - DKFZp686O13149
 - FN
 - DKFZp686F10164
 - FINC
 
  | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P02751#Fibronectinsbindcellsurfacesandvariouscompoundsincludingcollagen,fibrin,heparin,DNA,andactin.Fibronectinsareinvolvedincelladhesion,cellmotility,opsonization,woundhealing,andmaintenanceofcellshape.InteractionwithTNRmediatesinhibitionofcelladhesionandneuriteoutgrowth(Bysimilarity). SIZE:2386aminoacids;262607Da SUBUNIT:Mostlyheterodimersormultimersofalternativelysplicedvariants,connectedby2disulfidebondsnearthecarboxylends;toalesserextenthomodimers.InteractswithFBLN1,AMBP,TNR,LGALS3BPandCOL13A1. SUBCELLULARLOCATION:Secreted,extracellularspace,extracellularmatrix. TISSUESPECIFICITY:PlasmaFN(solubledimericform)issecretedbyhepatocytes.CellularFN(dimericorcross-linkedmultimericforms),madebyfibroblasts,epithelialandothercelltypes,isdepositedasfibrilsintheextracellularmatrix.Ugl-Y1,Ugl-Y2andUgl-Y3arefoundinurine.DEVELOPMENTALSTAGE:Ugl-Y1,Ugl-Y2andUgl-Y3arepresentintheurinefrom0to17yearsofage. PTM:Sulfated. SIMILARITY:SwissProt:P02751##Contains12fibronectintype-Idomains.&Contains2fibronectintype-IIdomains.&Contains16fibronectintype-IIIdomains. |