• <menu id="uuusw"></menu>
  • <table id="uuusw"></table>
    當前位置 : Millipore >>> Millipore/MAB5520 | Anti-NG2 Chondroitin Sulfate Proteoglycan Antibody, clone 7.1/MAB5520/100 µL
    Millipore/MAB5520 | Anti-NG2 Chondroitin Sulfate Proteoglycan Antibody, clone 7.1/MAB5520/100 µL
    • Millipore/MAB5520 | Anti-NG2 Chondroitin Sulfate Proteoglycan Antibody, clone 7.1/MAB5520/100 µL

    Millipore/MAB5520 | Anti-NG2 Chondroitin Sulfate Proteoglycan Antibody, clone 7.1/MAB5520/100 µL

    價格: ¥3816.00 市場價: 6360.00

    貨號: MAB5520
    品牌: Millipore
    規格
    數量
    庫存(0)
    特別 提示
    代購產品:無質量問題不接受退換貨,下單前請仔細核對信息。
    下單后請及時聯系客服核對商品價格,訂單生效后再付款。
    資深產品顧問
    咨詢顧問

    全國免費服務熱線

    4000-520-616


    • 自營商城 一站式服務
    • 廠家直采 剔除溢價
    • 品質甄選 正品保證
    • 嚴控流程 只做188精品
    • 極速物流 如約送貨
    • 詳情
    • 使用說明
    • 常見問題
      • Description
        CatalogueNumberMAB5520
        BrandFamilyChemicon®
        TradeName
        • Chemicon
        DescriptionAnti-NG2ChondroitinSulfateProteoglycanAntibody,clone7.1
        AlternateNames
        • NG2
        ProductInformation
        FormatAscites
        PresentationAscitesfluid.Liquid.Containsnopreservative.
        StorageandShippingInformation
        StorageConditionsMaintainat-20°Cinundilutedaliquotsforupto12monthsafterdateofreceipt.Avoidrepeatedfreeze/thawcycles.
        Applications
        ApplicationAnti-NG2ChondroitinSulfateProteoglycanAntibody,clone7.1isanantibodyagainstNG2ChondroitinSulfateProteoglycanforuseinFC&WB.
        KeyApplications
        • FlowCytometry
        • WesternBlotting
        ApplicationNotesWesternblot

        Flowcytometry

        Optimalworkingdilutionsmustbedeterminedbyenduser.
        BIOLOGicalInformation
        ImmunogenHumanbonemarrowstromalcellline,SV40transformed.
        Clone7.1
        HostMouse
        SpecificityNG2(chondroitinsulfateproteoglycan),humanwhichisthehomologueoftheratNG2molecule.Theantibodyreactswitha220-240kDsurfaceproteinwhoseN-terminalsequenceisidenticaltotheratNG2chondrotinsulfateproteoglycanmolecule.

        MAB5520reactswithonlyneoplasticleukocyteswithspecificassociationwithchromosome11q23translocationsinvolvingtheMLLgene.Ithasaveryhighspecificityfort(4;11)ort(11;19)translocations.Theantibodyshowsnoreactivitywithnormalmarrowhematopoieticcells,peripheralblldleukocytes,redbloodcellsorplatelets.LeukemiccellslinesKG1,KG1a,HRL,Jurkat,K562,Raji,HL-60,U937,Daudi,Nalm6andCEMarenegative.HoweverMAB5520doesreactwithavarietyofcelllinesofnonhematopoieticorigin,includingHeLacells.
        IsotypeIgG1
        SpeciesReactivity
        • Human
        AntibodyTypeMonoclonalAntibody
        EntrezGeneNumber
        EntrezGeneSummaryAhumanmelanoma-associatedchondroitinsulfateproteoglycanplaysaroleinstABIlizingcell-substratuminteractionsduringearlyeventsofmelanomacellspreADIngonendothelialbasementmembranes.CSPG4representsanintegralmembranechondroitinsulfateproteoglycanexpressedbyhumanmalignantmelanomacells.
        GeneSymbol
        • CSPG4
        • MSK16
        • MCSP
        • NG2
        • MCSPG
        • MEL-CSPG
        • HMW-MAA
        UniProtNumber
        UniProtSummaryFUNCTION:SwissProt:Q6UVK1#Proteoglycanplayingaroleincellproliferationandmigrationwhichstimulatesendothelialcellsmotilityduringmicrovascularmorphogenesis.Mayalsoinhibitneuriteoutgrowthandgrowthconecollapseduringaxonregeneration.Cellsurfacereceptorforcollagenalpha2(VI)whichmayconfercellsabilitytomigrateonthatsubstrate.BindsthroughitsextracellularN-terminusgrowthfactors,extracellularmatrixproteasesmodulatingtheiractivity.MayregulateMPP16-dependentdegradationandinvasionoftypeIcollagenparticipatinginmelanomacellsinvasionproperties.Maymodulatetheplasminogensystembyenhancingplasminogenactivationandinhibitingangiostatin.FunctionsalsoasasignaltransducingproteinbybindingthroughitscytoplasmicC-terminusscaffoldingandsignalingproteins.MaypromoteretractionfiberformationandcellpolarizationthroughRhoGTPaseactivation.Maystimulatealpha-4,beta-1integrin-mediatedadhesionandspreadingbyrecruitingandactivatingasignalingcascadethroughCDC42,ACK1andBCAR1.MayactivateFAKandERK1/ERK2signalingcascades.


        SIZE:2322aminoacids;250497Da

        SUBUNIT:InteractswiththefirstPDZdomainofMPDZ.InteractswithPRKCA.BindsTNC,laminin-1,COL5A1andCOL6A2.InteractswithPLGandangiostatin.BindsFGF2andPDGFA.InteractswithGRIP1,GRIP2andGRIA2.FormsaternarycomplexwithGRIP1andGRIA2(Bysimilarity).InteractswithLGALS3andtheintegrincomposedofITGB1andITGA3.InteractswithITGA4throughitschondroitinsulfateglycosaminoglycan.InteractswithBCAR1,CDC42andACK1.InteractswithMMP16.

        SUBCELLULARLOCATION:Apicalcellmembrane;Single-passtypeImembraneprotein(Bysimilarity).Cellprojection,lamellipodium(Bysimilarity).Note=LocalizedattheapicalplasmamembraneitrelocalizestothelamellipodiaofastrocytomauponphosphorylationbyPRKCA.Localizestotheretractionfibers.Localizestotheplasmamembraneofoligodendrocytes(Bysimilarity).

        TISSUESPECIFICITY:Detectedonlyinmalignantmelanomacells.



        PTM:N-glycosylated(Bysimilarity).&O-glycosylated;containsglycosaminoglycanchondroitinsulfatewhicharerequiredforproperlocalizationandfunctioninstressfiberformation(Bysimilarity).InvolvedininteractionwithMMP16andITGA4.&PhosphorylationbyPRKCAregulatesitssubcellularlocationandfunctionincellmotility(Bysimilarity).


        SIMILARITY:SwissProt:Q6UVK1##Contains15CSPG(NG2)repeats.&Contains2lamininG-likedomains.

        MISCELLANEOUS:ValuableMarkerforseveralincompletelydifferentiatedprecursorcells.
        PhysicochemicalInformation
        Dimensions
        MaterialsInformation
        MaterialsInformation
      售后保障
      螞蟻淘生物188,秉承螞蟻淘一貫的嚴謹態度,由螞蟻淘公司專業人員負責品控、采購、物流、銷售、售后,保障正品優質。以“快速好省,為科研提供好產品、好價格”為理念,直接鏈接原廠家,從全國各地原制造商嚴格挑選188款科研精品,剔除品牌溢價,188生物新電商,把好的產品帶給科研!? 力求給你最優質的商品。
    • Q:生物188產品正品保障嗎?
      A:生物188質量把控人員具有十年的從業經驗,在業界享有良好的口碑;自營商城,直接從廠家采購, 自己的團隊負責國際物流和清關,中間沒有第三方,所有流程嚴格把控,100%保證正品,假一罰十。

      Q:下單后可以修改訂單嗎?
      A:下單后的商品付款之前可以修改;訂單付款成功,需要聯系我們客服進行修改;客服電話:4000-520-616

      Q:可以開發票嗎?
      A:本網站所售商品都是正規清關,均開具16%正規發票,發票金額含配送費金額,另有說明的除外。

      Q:商品幾天可以發貨?
      A:生物188商品,全部現貨銷售,付款后即可發貨,一般一周內送達!

      Q:如何聯系商家?
      A:有任何問題夠可以電話咨詢我們,全國24小時免費服務熱線:4000-520-616 或聯系我們的在線客服QQ:1570468124

      Q:收到的商品少了/發錯了怎么辦?
      A:同個訂單購買多個商品可能會分為一個以上包裹發出,可能不會同時送達,建議查看訂單詳情是否是 部分發貨狀態;如未收到,可聯系在線客服或者致電4000-520-616。

      Q:退換貨/維修需要多長時間?
      A:一般情況下,退貨處理周期為客戶收到產品一個月內(以快遞公司顯示簽收時間為準),包裝規格、 數量、品種不符,外觀毀損、短缺或缺陷,請在收到貨24小時內申請退換貨;特殊商品以合同條款為準。

    何為188

    極簡而嚴謹,我們僅銷售188款生物醫學科研用品,款款都是爆款;因為少所以聚焦,聚焦甄選每一款產品,聚焦服務每一位客戶!

    關注我們 :

    點擊QQ聯系我們
    生物188微信

    關注188微信公眾號

    獲取最新優惠活動通知
    • 品質甄選,正品保證

    • 自營電商,廠家直采

    • 極簡主義,188精品

  • <menu id="uuusw"></menu>
  • <table id="uuusw"></table>
    上床视频