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    當前位置 ： Millipore >>> Millipore/MAB5352 | Anti-Notch 1 Antibody, clone mN1A/MAB5352/100 µg
    Millipore/MAB5352 | Anti-Notch 1 Antibody, clone mN1A/MAB5352/100 µg
    • Millipore/MAB5352 | Anti-Notch 1 Antibody, clone mN1A/MAB5352/100 µg

    Millipore/MAB5352 | Anti-Notch 1 Antibody, clone mN1A/MAB5352/100 µg

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    貨號: MAB5352
    品牌: Millipore
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      • Description
        CatalogueNumberMAB5352
        Replaces04-1046
        BrandFamilyChemicon®
        TradeName
        • Chemicon
        DescriptionAnti-Notch1Antibody,clonemN1A
        BackgroundInformationNotch1consistsofthreedomains.Theextracellulardomaincontaining36epidermalgrowthfactor(EGF)repeatsand3lin-12/Notchrepeats(LNR)andfunctionsasareceptorincell-cellinteractions.Thereisasingletransmembranedomain(TM).Theintracellulardomaincontainssixcdc10/ankyrinrepeats(cdc10)andthenewlydefinedNotchcytokineresponse(NCR)region,whichcontainsaputativebipartiteNLS(nuclearlocalizationsignal).
        ProductInformation
        FormatPurified
        Control
        • Infetaltissues,usespleen,brainstemandlung.Inmostadulttissues,uselymphoidtissues.
        PresentationPurifiedimmunoglobulin.Liquid.
        StorageandShippingInformation
        StorageConditionsMaintainfor1yearat2–8°Cfromdateofshipment.Aliquottoavoidrepeatedfreezingandthawing.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.
        Applications
        ApplicationAnti-Notch1Antibody,clonemN1AisahighqualityMouseMonoclonalAntibodyforthedetectionofNotch1&hasbeenvalidatedinICC,IHC,IP&WB.
        KeyApplications
        • Immunocytochemistry
        • Immunohistochemistry
        • Immunoprecipitation
        • WesternBlotting
        ApplicationNotesWesternblotusingECL

        Immunohistochemistry

        Immunocytochemistry

        Immunoprecipitation

        Optimalworkingdilutionsmustbedeterminedbytheenduser.
        BIOLOGicalInformation
        ImmunogenCdc10-NCRregionofmouseNotch1expressedasaGSTfusionprotein.
        ClonemN1A
        ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
        HostMouse
        SpecificityRecognizesNotch1,intracellulardomain.Theantibodyhasahighaffinityforthe"activated"intracellularformofNotch1,butalowaffinityforthefull-length(unprocessedorheterodimericcellsurface)forms.NoreactivitywithNotch2,3or4.
        IsotypeIgG1
        SpeciesReactivity
        • Mouse
        • Rat
        • Feline
        AntibodyTypeMonoclonalAntibody
        EntrezGeneNumber
        EntrezGeneSummaryThisgeneencodesamemberoftheNotchfamily.MembersofthisType1transmembraneproteinfamilysharestructuralcharacteristicsincludinganextracellulardomainconsistingofmultipleepidermalgrowthfactor-like(EGF)repeats,andanintracellulardomainconsistingofmultiple,differentdomaintypes.Notchfamilymembersplayaroleinavarietyofdevelopmentalprocessesbycontrollingcellfatedecisions.TheNotchsignalingnetworkisanevolutionarilyconservedintercellularsignalingpathwaywhichregulatesinteractionsbetweenphysicallyadjacentcells.InDrosophilia,notchinteractionwithitscell-boundligands(delta,serrate)establishesanintercellularsignalingpathwaythatplaysakeyroleindevelopment.Homologuesofthenotch-ligandshavealsobeenidentifiedinhuman,butpreciseinteractionsbetweentheseligandsandthehumannotchhomologuesremaintobedetermined.Thisproteiniscleavedinthetrans-Golginetwork,andpresentedonthecellsurfaceasaheterodimer.Thisproteinfunctionsasareceptorformembraneboundligands,andmayplaymultiplerolesduringdevelopment.
        GeneSymbol
        • NOTCH1
        • notch1
        • hN1
        • TAN1
        PurificationMethodProteinAPurfied
        UniProtNumber
        UniProtSummaryFUNCTION:SwissProt:P46531#Functionsasareceptorformembrane-boundligandsJagged1,Jagged2andDelta1toregulatecell-fatedetermination.Uponligandactivationthroughthereleasednotchintracellulardomain(NICD)itformsatranscriptionalactivatorcomplexwithRBP-Jkappaandactivatesgenesoftheenhancerofsplitlocus.Affectstheimplementationofdifferentiation,proliferationandapoptoticprograms.Maybeimportantfornormallymphocytefunction.Inalteredform,maycontributetotransformationorprogressioninsomeT-cellneoplasms.InvolvedinthematurationofbothCD4+andCD8+cellsinthethymus.MaybeimportantforfolliculardifferentiationandpossIBLycellfateselectionwithinthefollicle.Duringcerebellardevelopment,mayfunctionasareceptorforneuronalDNERandmaybeinvolvedinthedifferentiationofBergmannglia(Bysimilarity).
        SIZE:2556aminoacids;272500Da
        SUBUNIT:HeterodimerofaC-terminalfragmentN(TM)andanN-terminalfragmentN(EC)whichareprobablylinkedbydisulfidebonds.InteractswithDNER,DTX1,DTX2andRBPSUH.AlsointeractswithMAML1,MAML2andMAML3whichactastranscriptionalcoactivatorsforNOTCH1.
        SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein(Bysimilarity).&Notch1intracellulardomain:Nucleus(Bysimilarity).Note=FollowingproteolyticalprocessingNICDistranslocatedtothenucleus(Bysimilarity).
        TISSUESPECIFICITY:Infetaltissuesmostabundantinspleen,brainstemandlung.Alsopresentinmostadulttissueswhereitisfoundmainlyinlymphoidtissues.
        PTM:Synthesizedintheendoplasmicreticulumasaninactiveformwhichisproteolyticallycleavedbyafurin-likeconvertaseinthetrans-Golginetworkbeforeitreachestheplasmamembranetoyieldanactive,ligand-accessibleform.CleavageresultsinaC-terminalfragmentN(TM)andaN-terminalfragmentN(EC).Followingligandbinding,itiscleavedbyTNF-alphaconvertingenzyme(TACE)toyieldamembrane-associatedintermediatefragmentcallednotchextracellulartruncation(NEXT).Thisfragmentisthencleavedbypresenilindependentgamma-secretasetoreleaseanotch-derivedpeptidecontainingtheintracellulardomain(NICD)fromthemembrane(Bysimilarity).&Phosphorylated(Bysimilarity).
        DISEASE:SwissProt:P46531#NOTCH1truncationisassociatedwithT-cellacutelymphoblasticleukemia.&DefectsinNOTCH1areacauseofaorticvalvedisease[MIM:109730].Thedisorderconsistsofanearlydevelopmentaldefectintheaorticvalveandalaterde-repressionofcalciumdepositionthatcausesprogressiveaorticvalvedisease.CalcificationoftheaorticvalveisthethirdleADIngcauseofheartdiseaseinadults.Theincidenceincreaseswithage,anditisoftenassociatedwithabicUSPidaorticvalvepresentin1-2%ofthepopulation.
        SIMILARITY:SwissProt:P46531##BelongstotheNOTCHfamily.&Contains5ANKrepeats.&Contains36EGF-likedomains.&Contains3LNR(Lin/Notch)repeats.
        MolecularWeight272.5kDa(also230kDaprocessedform)
        PhysicochemicalInformation
        Dimensions
        MaterialsInformation
        MaterialsInformation
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