| Immunogen | Humanpheochromocytoma |
| Clone | LK2H10 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | Chromogranin,anacidicproteinhavingamolecularweightofabout68kDaABIdesinthepolypeptide-hormone-containingsecretorygranulesofhumanendocrinetissues.Anti-chromograninAcanbeusedtostainmostnormalandneoplasticendocrinetissuescontainingsecretorygranules(exceptionsincludecellsfromthehypothalamusandposteriorpituitary,whichareknowntocontainsecretorygranules).Theamountofstainingisusuallyproportionaltothenumberofsecretorygranulespresent(1). |
| Isotype | IgG1κ |
| SpeciesReactivity | |
| SpeciesReactivityNote | Human,mouse,rat,monkey,andporcine.Doesnotrecognizesheep,rabbitorguineapig. |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Theproteinencodedbythisgeneisamemberofthechromogranin/secretograninfamilyofneuroendocrinesecretoryproteins.Itisfoundinsecretoryvesiclesofneuronsandendocrinecells.Thisgeneproductisaprecursortothreebiologicallyactivepeptides;vasostatin,pancreastatin,andparastatin.Thesepeptidesactasautocrineorparacrinenegativemodulatorsoftheneuroendocrinesystem.Otherpeptides,includingchromostatin,beta-granin,WE-14andGE-25,arealsoderivedfromthefull-lengthprotein.However,biologicalactivitiesforthesemoleculeshavenotbeenshown. |
| GeneSymbol | |
| PurificationMethod | AmmoniumSulfatePrecipitation |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P10645#Pancreastatinstronglyinhibitsglucoseinducedinsulinreleasefromthepancreas. SIZE:457aminoacids;50730Da SUBCELLULARLOCATION:Secreted.Note=Neuroendocrineandendocrinesecretorygranules. PTM:Sulfatedontyrosineresiduesand/orcontainssulfatedglycans. SIMILARITY:SwissProt:P10645##Belongstothechromogranin/secretograninproteinfamily. MISCELLANEOUS:Bindscalciumwithalow-affinity |
| MolecularWeight | 50kDa |