| Immunogen | PurifiedGFAPfromporcinespinalcord. | 
| Clone | GA5 | 
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. | 
| Host | Mouse | 
| Specificity | Glialfibrillaracidicprotein.Onwesternblotsofextractsfromahumangliomacellline(U33CG/343MG),MAB360recognizesabandatapproximately51kDacorrespondingtoGFAP(Debus,1983).ByimmunohistochemistryitrecognizesastrocytesandBergmanngliacells,gliomaandglialcellderivedtumors.Showsnocross-reactivitywithvimentin. | 
| Isotype | IgG1 | 
| SpeciesReactivity | - Bovine
 - Chicken
 - Human
 - Mouse
 - Pig
 - Rat
 - Rabbit
 
  | 
| SpeciesReactivityNote | ReactswithBovine,Chicken,Human,Mouse,Porcine(Pig),RabbitandRat.Reactivitywithotherspecieshasnotbeendetermined. | 
| AntibodyType | MonoclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | Thisgeneencodesoneofthemajorintermediatefilamentproteinsofmatureastrocytes.Itisusedasamarkertodistinguishastrocytesfromotherglialcellsduringdevelopment.MutationsinthisgenecauseAlexanderdisease,araredisorderofastrocytesinthecentralnervoussystem.Anadditionaltranscriptvarianthasbeendescribed,butitsfulllengthsequencehasnotbeendetermined. | 
| GeneSymbol |  | 
| PurificationMethod | Unpurified | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P14136#GFAP,aclass-IIIintermediatefilament,isacell-specificmarkerthat,duringthedevelopmentofthecentralnervoussystem,distinguishesastrocytesfromotherglialcells. SIZE:432aminoacids;49880Da SUBUNIT:Isoform3interactswithN-terminusofPSEN1. SUBCELLULARLOCATION:Cytoplasm.Note=Associatedwithintermediatefilaments. DISEASE:SwissProt:P14136#DefectsinGFAPareacauseofAlexanderdisease[MIM:203450].Alexanderdiseaseisararedisorderofthecentralnervoussystem.ItisaprogressiveleukoencephalopathywhosehallmarkisthewidespreadaccumulationofRosenthalfiberswhicharecytoplasmicinclusionsinastrocytes.Themostcommonformaffectsinfantsandyoungchildren,andischaracterizedbyprogressivefailureofcentralmyelination,usuallyleADIngtodeathusuallywithinthefirstdecade.InfantswithAlexanderdiseasedevelopaleukoencephalopathywithmacrocephaly,seizures,andpsychomotorretardation.Patientswithjuvenileoradultformstypicallyexperienceataxia,bulbarsignsandspasticity,andamoreslowlyprogressivecourse. SIMILARITY:SwissProt:P14136##Belongstotheintermediatefilamentfamily. | 
| MolecularWeight | ~51kDa |