| Immunogen | Humanpheochromocytoma |
| Clone | PHE5 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | ChromograninA.Theantibodyhasbeenextensivelydocumentedonimmunohistochemicalstudiesindeparaffinizedmethacarnfixedtissue,whereitisasensitiveMarkerofneuroendocrinecellsandtumors.Notrecommendedforformalinfixedtissues,seeMAB5268orCBL219.Onwesternblots,itidentifiestheidenticalbandsrecognizedbyantibodyLK2H10(WilsonandLloyd). |
| Isotype | IgG1 |
| SpeciesReactivity | |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Theproteinencodedbythisgeneisamemberofthechromogranin/secretograninfamilyofneuroendocrinesecretoryproteins.Itisfoundinsecretoryvesiclesofneuronsandendocrinecells.Thisgeneproductisaprecursortothreebiologicallyactivepeptides;vasostatin,pancreastatin,andparastatin.Thesepeptidesactasautocrineorparacrinenegativemodulatorsoftheneuroendocrinesystem.Otherpeptides,includingchromostatin,beta-granin,WE-14andGE-25,arealsoderivedfromthefull-lengthprotein.However,biologicalactivitiesforthesemoleculeshavenotbeenshown. |
| GeneSymbol | |
| Non-ReactiveSpecies | |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P10645#Pancreastatinstronglyinhibitsglucoseinducedinsulinreleasefromthepancreas. SIZE:457aminoacids;50730Da SUBCELLULARLOCATION:Secreted.Note=Neuroendocrineandendocrinesecretorygranules. PTM:Sulfatedontyrosineresiduesand/orcontainssulfatedglycans. SIMILARITY:SwissProt:P10645##Belongstothechromogranin/secretograninproteinfamily. MISCELLANEOUS:Bindscalciumwithalow-affinity. |