| Immunogen | Ratserotonintransporter,N-terminus/GSTfusionprotein(aa1-85). |
| Clone | 17-7A4 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | RecognizesSerotoninTransporter. |
| Isotype | IgG1 |
| SpeciesReactivity | |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneSummary | Thisgeneencodesanintegralmembraneproteinthattransportstheneurotransmitterserotoninfromsynapticspacesintopresynapticneurons.Theencodedproteinterminatestheactionofserotoninandrecyclesitinasodium-dependentmanner.Thisproteinisatargetofpsychomotorstimulants,suchasamphetaminesandcocaine,andisamemberofthesodium:neurotransmittersymporterfamily.Arepeatlengthpolymorphisminthepromoterofthisgenehasbeenshowntoaffecttherateofserotoninuptakeandmayplayaroleinsuddeninfantdeathsyndrome,aggressivebehaviorinAlzheimerdiseasepatients,anddepression-susceptibilityinpeopleexperiencingemotionaltrauma. |
| GeneSymbol | |
| PurificationMethod | ProteinAPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P31645#Terminatestheactionofserotoninbyitshighaffinitysodium-dependentreuptakeintopresynapticterminals. SIZE:630aminoacids;70325Da SUBUNIT:InteractswithTGFB1I1. SUBCELLULARLOCATION:Membrane;Multi-passmembraneprotein. SIMILARITY:SwissProt:P31645##Belongstothesodium:neurotransmittersymporter(SNF)family. MISCELLANEOUS:Thisproteinisthetargetofpsychomotorstimulantssuchasamphetaminesorcocaine. |