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    當前位置 : Millipore >>> Millipore/MAB1149 | Anti-Tie-2 Antibody, extracellular, clone 4G8HE/MAB1149/100 µg
    Millipore/MAB1149 | Anti-Tie-2 Antibody, extracellular, clone 4G8HE/MAB1149/100 µg
    • Millipore/MAB1149 | Anti-Tie-2 Antibody, extracellular, clone 4G8HE/MAB1149/100 µg

    Millipore/MAB1149 | Anti-Tie-2 Antibody, extracellular, clone 4G8HE/MAB1149/100 µg

    價格: ¥3948.00 市場價: 6580.00

    貨號: MAB1149
    品牌: Millipore
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      • Description
        CatalogueNumberMAB1149
        BrandFamilyChemicon®
        TradeName
        • Chemicon
        DescriptionAnti-Tie-2Antibody,extracellular,clone4G8HE
        OverviewPurity:Greaterthan95%bySDS-PAGE.0.22micronsterilefiltered.
        AlternateNames
        • Angiopoietin-1Receptor
        • p140TEK
        BackgroundInformationTie-2isanendothelial-specificreceptortyrosinekinaseandareceptorforangiopoietin1.ItisatypeImembraneproteinthatisexpressedpredominantlyintheendotheliumofactivelygrowingbloodvesselsandmayrepresenttheearliestmammalianendothelialcelllineageMarker.Tie-2islikelyinvolvedintheregulationofendothelialcellproliferationanddifferentiationandmaydirectthespecialorientationofendothelialcellsduringtheformationofbloodvessels.
        ProductInformation
        FormatPurified
        Control
        • POSITIVECONTROL:placentaandlungtissue.
        PresentationImmunoglobulinpurifiedbyproteinGaffinitychromatography.LiquidinPBS,pH7.4,containing0.05%Bronidoxasapreservative.
        StorageandShippingInformation
        StorageConditionsMaintainrefrigeratedat2-8°Cinundilutedaliquotsforupto12months.
        Applications
        ApplicationAnti-Tie-2Antibody,extracellular,clone4G8HEdetectslevelofTie-2&hasbeenpublished&validatedforuseinELISA,FC&WB.
        KeyApplications
        • ELISA
        • FlowCytometry
        • WesternBlotting
        ApplicationNotesWesternblot:10μg/mL.Recognizesabandmigratingatapproximately140kDacorrespondingtomouseTie-2.

        FACS:10μg/mL

        ELISA

        Optimalworkingdilutionsmustbedeterminedbyenduser.
        BIOLOGicalInformation
        ImmunogenTheextracellulardomainofmouseTie-2receptor.
        Epitopeextracellular
        Clone4G8HE
        ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
        HostRat
        SpecificityRecognizesmouseTie-2Receptor.
        IsotypeIgG1
        SpeciesReactivity
        • Mouse
        AntibodyTypeMonoclonalAntibody
        EntrezGeneNumber
        EntrezGeneSummaryTheTEKreceptortyrosinekinaseisexpressedalmostexclusivelyinendothelialcellsinmice,rats,andhumans.Thisreceptorpossessesauniqueextracellulardomaincontaining2immunoglobulin-likeloopsseparatedby3epidermalgrowthfactor-likerepeatsthatareconnectedto3fibronectintypeIII-likerepeats.Theligandforthereceptorisangiopoietin-1.DefectsinTEKareassociatedwithinheritedvenousmalformations;theTEKsignalingpathwayappearstobecriticalforendothelialcell-smoothmusclecellcommunicationinvenousmorphogenesis.TEKiscloselyrelatedtotheTIEreceptortyrosinekinase.
        GeneSymbol
        • TEK
        • CD202B
        • TIE2
        • VMCM1
        • VMCM
        • hTIE2
        • CD202b
        • TIE-2
        • EC2.7.10.1
        UniProtNumber
        UniProtSummaryFUNCTION:SwissProt:Q02763#Thisproteinisaproteintyrosine-kinasetransmembranereceptorforangiopoietin1.Itmayconstitutetheearliestmammalianendothelialcelllineagemarker.Probablyregulatesendothelialcellproliferation,differentiationandguidestheproperpatterningofendothelialcellsduringbloodvesselformation.
        SIZE:1124aminoacids;125811Da
        SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein.
        TISSUESPECIFICITY:PredominantlyexpressedinendothelialcellsandtheirProgenitors,theangioblasts.Hasbeendirectlyfoundinplacentaandlung,withalowerlevelinumbilicalveinendothelialcells,brainandkidney.
        DISEASE:SwissProt:Q02763#DefectsinTEKareacauseofdominantlyinheritedvenousmalformations(VMCM)[MIM:600195];anerrorofvascularmorphogenesischaracterizedbydilated,serpiginouschannels.
        SIMILARITY:SwissProt:Q02763##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.Tiesubfamily.&Contains3EGF-likedomains.&Contains3fibronectintype-IIIdomains.&Contains2Ig-likeC2-type(immunoglobulin-like)domains.&Contains1proteinkinasedomain.
        PhysicochemicalInformation
        Dimensions
        MaterialsInformation
        MaterialsInformation
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