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    當前位置 : Millipore >>> Millipore/HT17MG-14K-PX25 | MILLIPLEX MAP Human TH17 Magnetic Bead Panel Premixed - 25 Plex - Immunology
    Millipore/HT17MG-14K-PX25 | MILLIPLEX <small>MAP</small> Human TH17 Magnetic Bead Panel Premixed - 25 Plex - Immunology
    • Millipore/HT17MG-14K-PX25 | MILLIPLEX <small>MAP</small> Human TH17 Magnetic Bead Panel Premixed - 25 Plex - Immunology

    Millipore/HT17MG-14K-PX25 | MILLIPLEX MAP Human TH17 Magnetic Bead Panel Premixed - 25 Plex - Immunology

    價格: ¥46848.00 市場價: 78080.00

    貨號: HT17MG-14K-PX25
    品牌: Millipore
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      • Description
        CatalogueNumberHT17MG-14K-PX25
        TradeName
        • MILLIPLEX
        DescriptionMILLIPLEXMAPHumanTH17MagneticBeadPanelPremixed-25Plex-ImmunologyMultiplexAssay
        OverviewEMDMillipore’sMILLIPLEX?MAPHumanTH17PremixedMagneticBeadPanelisa25-plexkittobeusedforthesimultaneousquantificationofthefollowinganalytesinserum,plasmaorculturesupernatantsamples:GM-CSF,IFN-γ,IL-1β,IL-2,IL-4,IL-5,IL-6,IL-9,IL-10,IL-12(p70),IL-13,IL-15,IL-17A,IL-17F,IL-17E/IL-25,IL-21,IL-22,IL-23,IL-27,IL-28A,IL-31,IL-33,MIP-3α/CCL20,TNF-αandTNFβ.

        MILLIPLEX?MAPoffersthebroadestselectionofanalytesacrossawiderangeofdiseasestatesandspecies.Oncetheanalytesofinteresthavebeenidentified,youcanrelyonthequalitythatwebuildintoeachkittoproduceresultsyoucantrust.Inadditiontotheassaycharacteristicslistedintheprotocol,otherperformancecriteriaevaluatedduringthevalidationprocessinclude:cross-reactivity,dilutionlinearity,kitstABIlityandsamplebehavior(e.g.detectabilityandstability).Eachpanelandkitmeetsstringentmanufacturingcriteriatoensurebatch-to-batchreproducibility.

        EachMILLIPLEX?MAPpanelandkitincludes:
        ?Qualitycontrols(QCs)providedtoqualifyassayperformance

        ?Comparisonofstandard(calibrator)andQClotstoareferencelottoensurelot-to-lotconsistency

        ?Optimizedserummatrixtomimicnativeanalyteenvironment

        ?Detectionantibodycocktailsdesignedtoyieldconsistentanalyteprofileswithinpanel


        MILLIPLEX?MAPoffersyou:
        oTheabilitytochooseanycombinationofanalytesfromourpanelofsevenanalytestodesignacustomkitthatbettermeetsyourneeds.
        oAconvenient“all-in-one”boxformatthatgivesyoutheassurancethatyouwillhaveallthenecessaryreagentsyouneedtorunyourassay.

        EMDMillipore’sMILLIPLEX?MAPHumanTH17MagneticBeadPremixedPanelispartofthemostversatilesystemavailableforcytokineresearch.FromoursingletomultiplexbioMarkersolutions,wepartnerwithyoutodesign,develop,analyticallyvalidateandbuildthemostcomprehensivelibraryavailableforproteindetectionandquantitation.
        BackgroundInformationCD4T-helpercellsaremajorplayersinadaptiveimmunity.Basedontheirexpressionprofileoftranscriptionfactorsandsecretedcytokines,thesecellsaredividedintothemajorsubsetsTh1,Th2,Th17andTregulatory(Treg)cells.Th1cells,inducedbyIL-12andenhancedbyIFNγ,secreteIFNγthatactivatesmacrophages.InducedbyIL-4,Th2cellsprimarilyproduceIL-4,IL-5,IL-13,IL-25andIL-17E,playingaroleinallergy.Tregcells,inducedbyTGFβ,producetheanti-inflammatorycytokinesIL-10andTGFβandfunctiontocontrolT-cellresponsestopreventautoimmunereactions.Th17cells,amorerecentlydiscoveredsubsetcharacterizedbytheproductionofIL-17,areinducedbyTGFβcombinedwithIL-23andIL-1βinhumans,andTGFβ,IL-6andIL-21inmice.ActivatedTh17cellssecreteIL-17A,IL-17F,IL-21,IL-22andTNFαtopromotetissueinflammation.

        Th17cellsareinvolvedintheclearanceofextracellularbacteriaandfungi.TheyareabundantintheintestinallaminapropriaandfunctionasabarrieragainstinvADIngpathogens.ExcessiveamountsofTh17cellshavebeenimplicatedinthepathogenesisofseveralautoimmunediseases,includingmultiplesclerosis,psoriasis,juvenilediabetes,rheumatoidarthritis,Crohn"sdiseaseandautoimmuneuveitis.Inaddition,Th17cellsplayanimportantroleintumordevelopment,progressionandmetastasis,potentiallyinbothpromotingandinhibitingtumorgrowth.

        TheMILLIPLEX?MAPHumanTH17MagneticBeadPanelenablesyoutofocusontherelevanceandtherapeuticpotentialofthemodulationofCD4T-helpercellcytokinesinyourresearchmodel.CoupledwiththeLuminexxMAP?platforminamagneticbeadformat,youreceivetheadvantageofidealspeedandsensitivity,allowingquantitativemultiplexdetectionofmultipleanalytessimultaneously,whichcandramaticallyimproveproductivity.
        ProductInformation
        DetectionmethodLuminexxMAP
        ConfigurationPremixed
        Precision,%
        • Inter-assay:<>
        • Intra-assay:<>
        PanelTypeMAGNETICCytokines/Chemokines
        StorageandShippingInformation
        StorageConditionsRecommendedstorageforkitcomponentsis2-8°C.
        Applications
        ApplicationSimultaneouslyanalyzemultipleTh17cytokineandchemokinebiomarkerswiththeTh17Bead-BasedMultiplexAssaysusingtheLuminextechnology,inhumanserum,plasmaandcellculturesamples.
        KeyApplications
        • Multiplexing
        ApplicationNotes?Thisisanovernightincubationassayrequiring25μLofneatplasmaorserum,or25μLcellculturesupernatantperwell.
        ?ThiskitmaybeusedfortheanalysisofalloranycombinationoftheTh17panelanalytesinserum,plasmaortissue/celllysateandculturesupernatant
        BIOLOGicalInformation
        SpeciesReactivity
        • Human
        AnalytesAvailable
        • GM-CSF
        • IFN-γ
        • IL-1β
        • IL-2
        • IL-4
        • IL-5
        • IL-6
        • IL-9
        • IL-10
        • IL-12(p70)
        • IL-13
        • IL-15
        • IL-17A
        • IL-17F
        • IL-17E/IL-25
        • IL-21
        • IL-22
        • IL-23
        • IL-27
        • IL-28A
        • IL-31
        • IL-33
        • MIP-3α/CCL20
        • TNF-α
        • TNFβ
        CrossReactivityCross-reactivitybetweentheantibodiesandanyoftheotheranalytesinthispanelisnon-detectableornegligIBLe.
        Accuracy
        • 79-107%
        PhysicochemicalInformation
        Sensitivity
        • Refertokitprotocolforsensitivitiesofindividualbiomarkers.
        StandardCurveRange
        • IL-17&IL-4,24-100,000pg/mL
        • GM-CSF&IL-27,61-250,000pg/mL
        • IFNγ,10-40,000pg/mL
        • IL-10,1-5000pg/mL
        • MIP-3α,IL-1β,IL-12(p70),IL-15,IL-21&IL-33,5-20,000pg/mL
        • IL-13,7-30,000pg/mL
        • IL-17A&IL-2,12-50,000pg/mL
        • IL-22&TNFβ,37-150,000pg/mL
        • IL-9,9-35,000pg/mL
        • IL-23,336-1,500,000pg/mL
        • IL-5,6-25,000pg/mL
        • IL-6&TNFα,3-10,000pg/mL
        • IL-17E/IL-25,488-2,000,000
        • IL-28a&IL-31,49-200,000pg/mL
        Dimensions
        MaterialsInformation
        MaterialsInformation
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