Antibody reactive against mammalian transfected lysate.
Storage Buffer:
In 1x PBS, pH 7.4
Storage Instruction:
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
MSDS:
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Datasheet:
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Publication Reference
1.
Laboratory diagnosis of paraneoplastic pemphigus.Poot AM, Diercks GF, Kramer D, Schepens I, Klunder G, Hashimoto T, Borradori L, Jonkman MF, Pas HHBr J Dermatol. 2013 Jun 25. doi: 10.1111/bjd.12479.
2.
The protease inhibitor alpha-2-macroglobulin-like-1 is the p170 antigen recognized by paraneoplastic pemphigus autoantibodies in human.Schepens I, Jaunin F, Begre N, Laderach U, Marcus K, Hashimoto T, Favre B, Borradori L.PLoS One. 2010 Aug 18;5(8):e12250.
Applications
Western Blot (Transfected lysate)
Western Blot analysis of A2ML1 expression in transfected 293T cell line (H00144568-T01) by A2ML1 MaxPab polyclonal antibody.Lane1:A2ML1 transfected lysate(17.38 KDa).Lane2:Non-transfected lysate.
The alpha-macroglobulin (AM) superfamily of proteins contains both complement components and protease inhibitors, including A2M (MIM 103950) and A2ML1. AM proteins display a unique trap mechanism of inhibition, by which the AM inhibitor undergoes a major conformational change upon its cleavage by a protease, thus trapping the protease and blocking it from subsequent substrate binding (Galliano et al., 2006 [PubMed 16298998]).[supplied by OMIM
Other Designations:
C3 and PZP-like, alpha-2-macroglobulin domain containing 9,OTTHUMP00000158614
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