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    當前位置 : Millipore >>> Millipore/FCMAB100P | Milli-Mark Anti-Phospho-Erk1/2 Antibody (Thr202/Tyr204, Thr185/Tyr187)-PE/FCMAB100P/100 tests
    Millipore/FCMAB100P | Milli-Mark Anti-Phospho-Erk1/2 Antibody (Thr202/Tyr204, Thr185/Tyr187)-PE/FCMAB100P/100 tests
    • Millipore/FCMAB100P | Milli-Mark Anti-Phospho-Erk1/2 Antibody (Thr202/Tyr204, Thr185/Tyr187)-PE/FCMAB100P/100 tests

    Millipore/FCMAB100P | Milli-Mark Anti-Phospho-Erk1/2 Antibody (Thr202/Tyr204, Thr185/Tyr187)-PE/FCMAB100P/100 tests

    價格: ¥3324.00 市場價: 5540.00

    貨號: FCMAB100P
    品牌: Millipore
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      • Description
        CatalogueNumberFCMAB100P
        TradeName
        • Milli-Mark
        DescriptionMilli-MarkAnti-Phospho-Erk1/2Antibody(Thr202/Tyr204,Thr185/Tyr187)-PE
        AlternateNames
        • Erk1
          Erk2
          p44-MAPK
          p42-MAPK
          MAPK2
          PRKM2
          p41mapk
          PRKM1
          p44
          ERK2
          P42MAPK
          ERK
          p42
          MAPK1
          ERT1
          ERT2
          Mitogen-activatedproteinkinase
          MAPKinase2
          MAPKianse1
          MAPK
        BackgroundInformationErk(Extracellularsignal-RelatedKinase)isafamilyoftwo,highlyhomologousproteinsdenotedasErk1(p44,MAPK3)andErk2(p42,MAPK1)thatbothfunctioninthesamepathway.ThetwoproteinsareoftenreferredtocollectivelyasErk1/2orp44/p42MAPkinase.TheErkpathwayisconsideredtheclassical,canonicalMAPK(Mitogen-ActivatedProteinKinase)signalingpathway.Itisanevolutionarilyconservedpathwaythatcontrolsandisacriticalregulatorofthegrowthandsurvivalthroughthepromotionofcellproliferationandthepreventionofapoptosis.Erkisinvolvedinthecontrolofmanyfundamentalcellularprocessesincludingcellproliferation,survival,differentiation,apoptosis,motilityandmetabolism.Erkisactivatedbygrowthfactorstimulationofreceptortyrosinekinases(RTKs),GPCR,and/orintegrinstimulation.ThisactivatestheRas-Raf-MEK-Erkpathwaythatresultsinthephosphorylation/activationofErk1/2(p44/p42)ontheTxYmotif(Thr202/Tyr204andThr185/Tyr187forErk1&Erk2,respectively).
        ProductInformation
        FormatPE
        Control
        • JurkatCells
        PresentationPurifiedRabbitmonoclonalsupernatantconjugatedtophycoerythrininbuffercontainingPBSwith0.05%sodiumazide
        StorageandShippingInformation
        StorageConditionsStablefor6monthsat2-8°Cfromdateofreceipt.Protectfromlight.
        Applications
        ApplicationThisMilli-MarkPhospho-Erk1/2antibodyisvalidatedforuseinFlow&WBforthedetectionoftheMilli-MarkPhospho-Erk1/2protein.
        KeyApplications
        • FlowCytometry
        • WesternBlotting
        BIOLOGicalInformation
        ImmunogenPhosphorylatedrecombinantpeptidecorrespondingtoaminoacidssurroundingthepTEpYmotifintheactivationloopofhumanphospho-Erk1/2,inwhichtheThrandTyrresiduesarephosphorylated
        EpitopePhosphorylatedThr185/PhosphorylatedTyr187
        CloneAW39R
        HostRabbit
        SpecificityAntibodyrecognizesRecognizesErk1&2onlywhenduallyphosphorylatedonitsTxYactivationmotif.
        IsotypeIgG
        SpeciesReactivity
        • Human
        • Mouse
        • Rat
        SpeciesReactivityNoteTestedandpassedonHuman.basedon100%sequencehomology.
        AntibodyTypeMonoclonalAntibody
        EntrezGeneNumber
        EntrezGeneSummaryTheproteinencodedbythisgeneisamemberoftheMAPkinasefamily.MAPkinases,alsoknownasextracellularsignal-regulatedkinases(ERKs),actasanintegrationpointformultiplebiochemicalsignals,andareinvolvedinawidevarietyofcellularprocessessuchasproliferation,differentiation,transcriptionregulationanddevelopment.Theactivationofthiskinaserequiresitsphosphorylationbyupstreamkinases.Uponactivation,thiskinasetranslocatestothenucleusofthestimulatedcells,whereitphosphorylatesnucleartargets.Twoalternativelysplicedtranscriptvariantsencodingthesameprotein,butdifferingintheUTRs,havebeenreportedforthisgene.
        GeneSymbol
        • Erk1
        • Erk2
        • p44-MAPK
        • p42-MAPK
        • MAPK2
        • PRKM2
        • p41mapk
        • PRKM1
        • p44
        • ERK2
        • P42MAPK
        • ERK
        • p42
        • MAPK1
        • ERT1
        • ERT2
        • Mitogen-activatedproteinkinase
        • MAPKinase2
        • MAPKinase1
        • MAPK
        Modifications
        • Phosphorylation
        PurificationMethodProteinAPurfied
        UniProtNumber
        UniProtSummaryFUNCTION:SwissProt:P28482#Involvedinboththeinitiationandregulationofmeiosis,mitosis,andpostmitoticfunctionsindifferentiatedcellsbyphosphorylatinganumberoftranscriptionfactorssuchasELK1.PhosphorylatesEIF4EBP1;requiredforinitiationoftranslation.Phosphorylatesmicrotubule-associatedprotein2(MAP2).PhosphorylatesSPZ1(Bysimilarity).Phosphorylatesheatshockfactorprotein4(HSF4).
        COFACTOR:Magnesium(Bysimilarity).
        SIZE:360aminoacids;41390Da
        SUBUNIT:InteractswithMORG1(Bysimilarity).BindstoHIV-1NefthroughitsSH3domain.Thisinteractioninhibitsitstyrosine-kinaseactivity.InteractswithHSF4.
        DOMAIN:SwissProt:P28482TheTXYmotifcontainsthethreonineandtyrosineresidueswhosephosphorylationactivatestheMAPkinases.
        PTM:DuallyphosphorylatedonThr-185andTyr-187,whichactivatestheenzyme.
        SIMILARITY:Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.MAPkinasesubfamily.&Contains1proteinkinasedomain.
        MolecularWeight42kDaand44kDaObserved
        PhysicochemicalInformation
        Dimensions
        MaterialsInformation
        MaterialsInformation
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