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    當前位置 : Millipore >>> Millipore/FCABS319PE | Milli-Mark Anti-MAP Kinase 1/2 (Erk1/2) Antibody, CT -PE/FCABS319PE/100 tests
    Millipore/FCABS319PE | Milli-Mark Anti-MAP Kinase 1/2 (Erk1/2) Antibody, CT -PE/FCABS319PE/100 tests
    • Millipore/FCABS319PE | Milli-Mark Anti-MAP Kinase 1/2 (Erk1/2) Antibody, CT -PE/FCABS319PE/100 tests

    Millipore/FCABS319PE | Milli-Mark Anti-MAP Kinase 1/2 (Erk1/2) Antibody, CT -PE/FCABS319PE/100 tests

    價格: ¥3204.00 市場價: 5340.00

    貨號: FCABS319PE
    品牌: Millipore
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      • Description
        CatalogueNumberFCABS319PE
        TradeName
        • Milli-Mark
        DescriptionMilli-MarkAnti-MAPKinase1/2(Erk1/2)Antibody,CT-PE
        BackgroundInformationTheextracellularsignal-regulatedkinases1and2(ERK1andERK2),alsocalledp44andp42MAPkinases,aremembersoftheMitogenActivatedProteinKinase(MAPK)familyofproteinsfoundinalleukaryotes.Becausethe44kDaERK1andthe42kDaERK2arehighlyhomologousandbothfunctioninthesameproteinkinasecascade,thetwoproteinsareoftenreferredtocollectivelyasERK1/2orp44/p42MAPkinase.TheERK1/2signalingcascadehasbeenshowntobeacriticalregulatorofcelldifferentiation,cellphysiologyandneuronalfunction.AberrantcontrolofERK1/2activityhasbeenimplicatedinavarietyofpathologicalconditions,includingcancerandautoimmunediseases,andefficientstudymethodsareindemand.
        ProductInformation
        FormatPhycoerythrin
        Control
        • A431cells
        PresentationPurifiedrabbitpolyclonalIgGconjugatedtoPEinPBSwith0.1%sodiumazideand15mg/mLBSA.
        StorageandShippingInformation
        StorageConditionsMaintainrefrigeratedat2-8°Cprotectedfromlightinundilutedaliquotsforupto6monthsfromdateofreceipt.
        Applications
        ApplicationThisMilli-MarkAnti-MAPKinase1/2(Erk1/2)Antibody,CT-PEisvalidatedforuseinFCforthedetectionofMAPKinase1/2(Erk1/2).
        KeyApplications
        • FlowCytometry
        BIOLOGicalInformation
        Immunogen35residuesyntheticpeptidecorrespondingtotheC-terminusofratMAPKinase2/Erk2.
        HostRabbit
        SpecificityAntibodyrecognizesMAPK1/Erk1andMAPK2/Erk2
        IsotypeIgG
        SpeciesReactivity
        • Avian
        SpeciesReactivityNoteTestedandpassedonHuman.Unconjugatedversion(Cat.No.06-182)isknowntoreactwithAvian,Mouse,Rat,Sheep,Xenopus,Echinoderms.

        AntibodyTypePolyclonalAntibody
        EntrezGeneNumber
        EntrezGeneSummaryTheproteinencodedbythisgeneisamemberoftheMAPkinasefamily.MAPkinases,alsoknownasextracellularsignal-regulatedkinases(ERKs),actasanintegrationpointformultiplebiochemicalsignals,andareinvolvedinawidevarietyofcellularprocessessuchasproliferation,differentiation,transcriptionregulationanddevelopment.Theactivationofthiskinaserequiresitsphosphorylationbyupstreamkinases.Uponactivation,thiskinasetranslocatestothenucleusofthestimulatedcells,whereitphosphorylatesnucleartargets.Twoalternativelysplicedtranscriptvariantsencodingthesameprotein,butdifferingintheUTRs,havebeenreportedforthisgene.
        GeneSymbol
        • MAPK1
        • p38
        • ERK
        • P42MAPK
        • ERK2
        • p40
        • PRKM1
        • p41mapk
        • PRKM2
        • MAPK2
        • p42-MAPK
        • p41
        • ERK-2
        • ERT1
        PurificationMethodAntigenAffinity
        UniProtNumber
        UniProtSummaryFUNCTION:SwissProt:P28482#Involvedinboththeinitiationandregulationofmeiosis,mitosis,andpostmitoticfunctionsindifferentiatedcellsbyphosphorylatinganumberoftranscriptionfactorssuchasELK1.PhosphorylatesEIF4EBP1;requiredforinitiationoftranslation.Phosphorylatesmicrotubule-associatedprotein2(MAP2).PhosphorylatesSPZ1(Bysimilarity).Phosphorylatesheatshockfactorprotein4(HSF4).

        COFACTOR:Magnesium(Bysimilarity).

        SIZE:360aminoacids;41390Da

        SUBUNIT:InteractswithMORG1(Bysimilarity).BindstoHIV-1NefthroughitsSH3domain.Thisinteractioninhibitsitstyrosine-kinaseactivity.InteractswithHSF4.

        DOMAIN:SwissProt:P28482TheTXYmotifcontainsthethreonineandtyrosineresidueswhosephosphorylationactivatestheMAPkinases.

        PTM:DuallyphosphorylatedonThr-185andTyr-187,whichactivatestheenzyme.

        SIMILARITY:Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.MAPkinasesubfamily.&Contains1proteinkinasedomain.
        MolecularWeight41.4kDaCalculated
        PhysicochemicalInformation
        Dimensions
        MaterialsInformation
        MaterialsInformation
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