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    當前位置 : dianova >>> dianova/Anti-CD73 (Hu) aus Maus (KK3) – unkonj./500 μl/DIA-KK3
    dianova/Anti-CD73 (Hu) aus Maus (KK3) – unkonj./500 μl/DIA-KK3
    • dianova/Anti-CD73 (Hu) aus Maus (KK3) – unkonj./500 μl/DIA-KK3

    dianova/Anti-CD73 (Hu) aus Maus (KK3) – unkonj./500 μl/DIA-KK3

    價格: ¥4880.00 市場價: 9760.00

    貨號: DIA-KK3
    品牌: dianova
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      • übersicht
        ArtikelnummerDIA-KK3
        Spezifit?t

        CD73

        Spezies-Reaktivit?t

        Human

        Immunogen

        Rekombinantes Peptid von humanem CD73

        Wirtsspezies

        Maus

        Isotyp

        IgG2a/k

        Klon

        KK3

        Klonalit?t (Mono-/Polyklonal)

        monoklonal

        Anwendung

        Immunhistochemie (IHC), Immunhistochemie (Paraffingewebe), Western Blot

        Konjugation

        unkonjugiert

        Verdünnung

        Immunhistochemie (IHC): 1:100 – 1:200

        Format

        0,05% NaN3, 2% BSA, gereinigter Antik?rper (aus Kulturüberstand), in PBS (pH 7,4), Lyophilisat

        Produktlinie / Thema

        Immunonkologie, Tumormarker/-biologie

        Zweckbestimmung

        nur für Forschungszwecke

        Temperatur - Lagerung

        2-8°C

        Temperatur - Transport

        bei Raumtemperatur

        Suchcode

        DIAKK3, KK3, IHC, FFPE, Paraffin

        Hersteller / Marke

        ONCOdianova

        Uniprot_ID

        P21589

        Gene_ID

        4907

        Alias

        5-NT, 5-Nucleotidase, 5'-Nucleotidase, 5'-Nucleotidase, Ecto, E5-NT, E5NT, EN, ENT, NT5-E, Nt5e

      • Datenbl?tter und Downloads
        • Datasheet_DIA-KK3_anti-CD73
        • MSDS_ONCOdianova_V02
      • Weitere Produktinformationen
        Clone KK3 has been developed and validated specifically for the immunohistochemical (IHC) detection of CD73 in routine FFPE human tissue specimen. Given the broad expression of ectonucleotidases and adenosine receptors, immunohisto-chemical (IHC) application of monoclonal antibody KK3 may help to develop a better understanding of cell- and tissue- specific roles.

        CD73 and CD39 are cell surface enzymes that catabolize the breakdown of extracellular ATP into adenosine. As ectonucleo-sidases they play important roles in maintaining tissue and immune homeostasis through interfering with the extracellular purigeneric pathway. Since several labs independently have demonstrated an immunosuppressive role of CD73-adenosine in cancer, the CD73-adenosine axis has emerged as one of the most promising therapeutic targets in immuno-oncology.

        Adenosine triphosphate (ATP) is the major source of energy for the cell. Malignant cells can release high levels of ATP (e.g. after damage by radiotherapy or chemotherapy). Extracellular ATP provokes inflammation by driving "purinergic signals&rsquo? and plays a significant role in promoting anti-tumor responses. Many tumors express the ectonucleotidases CD39 and CD73 to scarve such proinflammatory mediators and generate immunosuppressive adenosine nucleosides.

      • Bilder
        CD73 immunohistochemistry in a tonsil.
        CD73 immunohistochemistry in a tonsil.
        Strong homogeneous CD73 immunostaining in a cholangiocellular carcinoma of the liver.
        Strong homogeneous CD73 immunostaining in a cholangiocellular carcinoma of the liver.
        Membranous CD73 immunostaining in an adenocarcinoma of the lung shows apical predominance.
        Membranous CD73 immunostaining in an adenocarcinoma of the lung shows apical predominance.
        Prominent membranous CD73 positivity in a malignant melanoma.
        Prominent membranous CD73 positivity in a malignant melanoma.
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