| Immunogen | 12aminoacidpeptideoftheC-terminusofhGLUT-1{LFHPLGADSQV}conjugatedtoKLH |
| Epitope | C-terminus |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | Specificforhumanglucosetransporter1frommuscleandadiposetissue.Doesnotcross-reactwithGLUT-4.Themolecularweightoftheglucosetransporterprecipitatedbytheserumisapproximately46kDa. |
| SpeciesReactivity | |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Glucosetransportersareintegralmembraneglycoproteinsinvolvedintransportingglucoseintomostcells.GLUT1isamajorglucosetransporterinthemammalianblood-brainbarrier.Itispresentathighlevelsinprimateerythrocytesandbrainendothelialcells.[suppliedbyOMIM] |
| GeneSymbol | - SLC2A1
- GLUT-1
- MGC141896
- GLUT1
- MGC141895
- GLUT
|
| PurificationMethod | ImmunoAffinityPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P11166#Facilitativeglucosetransporter.ThisisoformmayberesponsIBLeforconstitutiveorbasalglucoseuptake.Hasaverybroadsubstratespecificity;cantransportawiderangeofaldosesincludingbothpentosesandhexoses. SIZE:492aminoacids;54084Da SUBCELLULARLOCATION:Cellmembrane;Multi-passmembraneprotein(Bysimilarity).Melanosome.Note=Localizesprimarilyatthecellsurface(Bysimilarity).IdentifiedbymassspectrometryinmelanosomefractionsfromstageItostageIV. TISSUESPECIFICITY:Expressedatvariablelevelsinmanyhumantissues. PTM:PhosphorylateduponDNAdamage,probablybyATMorATR. DISEASE:SwissProt:P11166#DefectsinSLC2A1arethecauseofautosomaldominantGLUT1deficiencysyndrome[MIM:606777].Thisdiseasecausesadefectinglucosetransportacrosstheblood-brainbarrier.Itischaracterizedbyinfantileseizures,delayeddevelopment,andacquiredmicrocephaly. SIMILARITY:SwissProt:P11166##Belongstothemajorfacilitatorsuperfamily.Sugartransporter(TC2.A.1.1)family.Glucosetransportersubfamily. |
| MolecularWeight | 46kDa |