| Immunogen | B10mousespleencellsenrichedwithTcells | 
| Clone | M1/70.15.1 | 
| Host | Rat | 
| Specificity | Theantibodyrecognizesadifferentiationantigensituatedonmononuclearphagocytesandgranulocytes.Theexpressionofthisantigen(Mac1)increasesduringmonocytematuration.
  FUSIONPARTNER:NS1/1.Ag4.1mousemyelomacellline | 
| Isotype | IgG2b | 
| SpeciesReactivity |  | 
| AntibodyType | MonoclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | ThisgeneencodestheintegrinalphaMchain.Integrinsareheterodimericintegralmembraneproteinscomposedofanalphachainandabetachain.ThisI-domaincontainingalphaintegrincombineswiththebeta2chain(ITGB2)toformaleukocyte-specificintegrinreferredtoasmacrophagereceptor1("Mac-1"),orinactivated-C3b(iC3b)receptor3("CR3").ThealphaMbeta2integrinisimportantintheadherenceofneutrophilsandmonocytestostimulatedendothelium,andalsointhephagocytosisofcomplementcoatedparticles.SomeintegrinalphaMproteinscontainaninsertedaminoacid(Q,betweenAApositions499and500)resultingfroma3bpshiftinaspliceacceptorthatinsertsthecodonCAG;receptorswithorwithouttheextraaminoacidarefunctionallyindistinguishable | 
| GeneSymbol | - ITGAM
 - MO1A
 - CD11b
 - MAC1A
 - CD11B
 - MAC-1
 - CR3A
 - MGC117044
 
  | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P11215#Integrinalpha-M/beta-2isimplicatedinvariousadhesiveinteractionsofmonocytes,macrophagesandgranulocytesaswellasinmediatingtheuptakeofcomplement-coatedparticles.ItisidenticalwithCR-3,thereceptorfortheiC3bfragmentofthethirdcomplementcomponent.ItprobablyrecognizestheR-G-DpeptideinC3b.Integrinalpha-M/beta-2isalsoareceptorforfibrinogen,factorXandICAM1.ItrecognizesP1andP2peptidesoffibrinogengammachain. SIZE:1152aminoacids;127179Da SUBUNIT:Heterodimerofanalphaandabetasubunit.Alpha-Massociateswithbeta-2. SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. TISSUESPECIFICITY:Predominantlyexpressedinmonocytesandgranulocytes. DOMAIN:SwissProt:P11215TheintegrinI-domain(insert)isaVWFAdomain.IntegrinswithI-domainsdonotundergoproteasecleavage. SIMILARITY:Belongstotheintegrinalphachainfamily.&Contains7FG-GAPrepeats.&Contains1VWFAdomain. |