2-(p-Hydroxyanilino)-4-(p-chlorophenyl)thiazole (SK1-II) is a cell permeable, potent, and specific inhibitor of sphingosine kinase (IC50 = 0.5 μM). The compound does not bind to the ATP-binding site and does not affect the kinase activities of hERK2, hPI3K, or hPKCα at concentrations up to 60 μM. SK1-II showed anti-tumor properties, inducing apoptosis in a number of cell lines including those that express Pgp or MRP1 drug-transport proteins.
| Categories | Biochemical Reagents |
|---|
| Filter | Inhibitor, Sphingolipid |
|---|
| CAS Number | 312636-16-1 |
|---|
| Molecular Formula | C15H11ClN2OS-HCl |
|---|
| Molecular Weight (g/mol) | 339.2 |
|---|
| Purity | >95% |
|---|
| Storage | 4 °C or below |
|---|
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