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    當前位置 ： Millipore >>> Millipore/ABS150 | Anti-phospho-PDGFRα (Tyr754) Antibody/ABS150/200 µg
    Millipore/ABS150 | Anti-phospho-PDGFRα (Tyr754) Antibody/ABS150/200 µg
    • Millipore/ABS150 | Anti-phospho-PDGFRα (Tyr754) Antibody/ABS150/200 µg

    Millipore/ABS150 | Anti-phospho-PDGFRα (Tyr754) Antibody/ABS150/200 µg

    價格: ￥3324.00 市場價: 5540.00
    打印產品信息
    貨號: ABS150
    品牌: Millipore
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      • Description
        CatalogueNumberABS150
        DescriptionAnti-phospho-PDGFRα(Tyr754)Antibody
        AlternateNames
        • Platelet-derivedgrowthfactorreceptoralpha
        • PDGF-R-alpha
        • PDGFR-alpha
        • Alphaplatelet-derivedgrowthfactorreceptor
        • Alpha-typeplatelet-derivedgrowthfactorreceptor
        • CD140antigen-likefamilymemberA
        • CD140aantigen
        • Platelet-derivedgrowthfactoralphareceptor
        • Platelet-derivedgrowthfactorreceptor2
        • Shortname=PDGFR-2
        • CD_antigen=CD140a
        BackgroundInformationPDGFRα(platelet-derivedgrowthfactor;Alpha-typeplatelet-derivedgrowthfactorreceptor;CD140antigen-likefamilymemberA)isaubiquitousreceptortyrosinekinase.Itisactivatedbythebindingofhomo-orheterodimersofPDGFA,PDGFBorPDGFC.Uponligandbinding,PDGFRαdimerizesastwoalphaortwobetasubunitsdependingonthecellularcontext,andisautophosphorylatedatmultipletyrosineresidues.Phosphorylatedtyrosineresiduesinteractwithdifferenttargetstomediatecellproliferation,migration,andsurvival.PhosphorylationatTyrosine754inducesheterodimerizationandallowsPDGFRαtointeractwithPTPN11.Inaddition,PDGRαregulatesapoptosisbymultiplesignalingpathwaysthatconvergeonproapoptoticproteinssuchasBAD.Forinstance,PDGFRαsignalingdeactivatesBADbyinductionofPI3K/Akt;PLC-gamma/PKC/Bcl-2;andRas/Raf/Erksignalingpathways.DefectivePDGFRαhasbeenimplicatedin?hypereosinophilicsyndromeandgastrointestinalstromaltumor.
        ProductInformation
        FormatAffinityPurified
        Control
        • UntreatedandPDGFtreatedNIH/3T3celllysates
        PresentationPurifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide.
        StorageandShippingInformation
        StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
        Applications
        ApplicationDetectphospho-PDGFRα(Tyr754)usingthisAnti-phospho-PDGFRα(Tyr754)AntibodyvalidatedforuseinWesternBlotting.
        KeyApplications
        • WesternBlotting
        BIOLOGicalInformation
        ImmunogenKLH-conjugatedlinearpeptidecorrespondingtohumanPDGFRαphosphorylatedat(Tyr754).
        EpitopePhosphorylated(Tyr754)
        ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
        HostRabbit
        SpecificityThisantibodyrecognizesPDGFRαphosphorylatedat(Tyr754).
        SpeciesReactivity
        • Mouse
        • Human
        • Rat
        • Bovine
        SpeciesReactivityNoteDemonstratedtoreactwithMouse.PredictedtoreactwithHuman,Rat,andBovinebasedon100%sequencehomology.Otherhomologies:XenopusandChicken(91%sequencehomology).
        AntibodyTypePolyclonalAntibody
        EntrezGeneNumber
        EntrezGeneSummaryThisgeneencodesacellsurfacetyrosinekinasereceptorformembersoftheplatelet-derivedgrowthfactorfamily.Thesegrowthfactorsaremitogensforcellsofmesenchymalorigin.Theidentityofthegrowthfactorboundtoareceptormonomerdetermineswhetherthefunctionalreceptorisahomodimeroraheterodimer,composedofbothplatelet-derivedgrowthfactorreceptoralphaandbetapolypeptides.Studiesinknockoutmice,wherehomozygosityislethal,indicatethatthealphaformoftheplatelet-derivedgrowthfactorreceptorisparticularlyimportantforkidneydevelopmentsincemiceheterozygousforthereceptorexhibitdefectivekidneyphenotypes.[providedbyRefSeq,Jul2008].
        GeneSymbol
        • PDGFRA
        • PDGFR2
        • RHEPDGFRA
        Modifications
        • Phosphorylation
        PurificationMethodAffinityPurfied
        UniProtNumber
        UniProtSummaryFUNCTION:Tyrosine-proteinkinasethatactsasacell-surfacereceptorforPDGFA,PDGFBandPDGFCandplaysanessentialroleintheregulationofembryonicdevelopment,cellproliferation,survivalandchemotaxis.Dependingonthecontext,promotesorinhibitscellproliferationandcellmigration.Playsanimportantroleinthedifferentiationofbonemarrow-derivedmesenchymalstemcells.Requiredfornormalskeletondevelopmentandcephalicclosureduringembryonicdevelopment.Requiredfornormaldevelopmentofthemucosaliningthegastrointestinaltract,andforrecruitmentofmesenchymalcellsandnormaldevelopmentofintestinalvilli.Playsaroleincellmigrationandchemotaxisinwoundhealing.Playsaroleinplateletactivation,secretionofagoNISTsfromplateletgranules,andinthrombin-inducedplateletaggregation.Bindingofitscognateligands-homodimericPDGFA,homodimericPDGFB,heterodimersformedbyPDGFAandPDGFBorhomodimericPDGFC-leadstotheactivationofseveralsignalingcascades;theresponsedependsonthenatureoftheboundligandandismodulatedbytheformationofheterodimersbetweenPDGFRAandPDGFRB.PhosphorylatesPIK3R1,PLCG1,andPTPN11.ActivationofPLCG1leadstotheproductionofthecellularsignalingmoleculesdiacylglycerolandinositol-1,4,5-trisphosphate,mobilizationofcytosolicCa2+andtheactivationofproteinkinaseC.PhosphorylatesPIK3R1,theregulatorysubunitofphosphatidylinositol3-kinase,andtherebymediatesactivationoftheAKT1signalingpathway.MediatesactivationofHRASandoftheMAPkinasesMAPK1/ERK2and/orMAPK3/ERK1.PromotesactivationofSTATfamilymembersSTAT1,STAT3andSTAT5Aand/orSTAT5B.Receptorsignalingisdown-regulatedbyproteinphosphatasesthatdephosphorylatethereceptoranditsdown-streameffectors,andbyrapidinternalizationoftheactivatedreceptor.

        CATALYTICACTIVITY:ATP+a[protein]-L-tyrosine=ADP+a[protein]-L-tyrosinephosphate.

        ENZYMEREGULATION:Presentinaninactiveconformationintheabsenceofboundligand.BindingofPDGFAand/orPDGFBleadstodimerizationandactivationbyautophosphorylationontyrosineresidues.Inhibitedbyimatinib,nilotinibandsorafenib.

        SUBUNITSTRUCTURE:InteractswithhomodimericPDGFA,PDGFBandPDGFC,andwithheterodimersformedbyPDGFAandPDGFB.Monomerintheabsenceofboundligand.InteractionwithdimericPDGFA,PDGFBand/orPDGFCleadstoreceptordimerization,wherebothPDGFRAhomodimersandheterodimerswithPDGFRBareobserved.Interacts(tyrosinephosphorylated)withSHB(viaSH2domain)(Bysimilarity).Interacts(tyrosinephosphorylated)withSHF(viaSH2domain).Interacts(tyrosinephosphorylated)withSRC(viaSH2domain).Interacts(tyrosinephosphorylated)withPIK3R1.Interacts(tyrosinephosphorylated)withPLCG1(viaSH2domain).Interacts(tyrosinephosphorylated)withCRK,GRB2andGRB7.SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein.Note:Theactivatedreceptorisrapidlyinternalizedanddegraded.

        TISSUESPECIFICITY:Detectedinplatelets(atproteinlevel).Widelyexpressed.Detectedinbrain,fibroblasts,smoothmuscle,heart,andembryo.Expressedinprimaryandmetastaticcolontumorsandinnormalcolontissue.

        PTM:N-glycosylated.

        Ubiquitinated,leADIngtoitsdegradationProbable.

        Autophosphorylatedontyrosineresiduesuponligandbinding.Autophosphorylationoccursintrans,i.e.onesubunitofthedimericreceptorphosphorylatestyrosineresiduesontheothersubunit.PhosphorylationatTyr-731andTyr-742isimportantforinteractionwithPIK3R1.PhosphorylationatTyr-720andTyr-754isimportantforinteractionwithPTPN11.PhosphorylationatTyr-762isimportantforinteractionwithCRK.PhosphorylationatTyr-572andTyr-574isimportantforinteractionwithSRCandSRCfamilymembers.PhosphorylationatTyr-988andTyr-1018isimportantforinteractionwithPLCG1.

        INVOLVEMENTINDISEASE:Note=AchromosomalaberrationinvolvingPDGFRAisfoundinsomecasesofhypereosinophilicsyndrome.Interstitialchromosomaldeletiondel4(q12q12)causesthefusionofFIP1L1andPDGFRA(FIP1L1-PDGFRA).Mutationsthatcauseoverexpressionand/orconstitutiveactivationofPDGFRAmaybeacauseofhypereosinophilicsyndrome.

        DefectsinPDGFRAareacauseofgastrointestinalstromaltumor(GIST)[MIM:606764].Note=MutationsthatcauseconstitutiveactivationofPDGFRAmaybeacauseofgastrointestinalstromaltumor(GIST).

        SEQUENCESIMILARITIES:Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.CSF-1/PDGFreceptorsubfamily.

        Contains5Ig-likeC2-type(immunoglobulin-like)domains.

        Contains1proteinkinasedomain.

        SEQUENCECAUTION:ThesequenceAAP69563.1differsfromthatshown.Reason:Erroneousinitiation.TranslationN-terminallyshortened.
        MolecularWeight~180kDaobserved
        PhysicochemicalInformation
        Dimensions
        MaterialsInformation
        MaterialsInformation
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