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    當前位置 ： Millipore >>> Millipore/ABE208 | Anti-β-Catenin Antibody/ABE208/100 µg
    Millipore/ABE208 | Anti-β-Catenin Antibody/ABE208/100 µg
    • Millipore/ABE208 | Anti-β-Catenin Antibody/ABE208/100 µg

    Millipore/ABE208 | Anti-β-Catenin Antibody/ABE208/100 µg

    價格: ￥3696.00 市場價: 6160.00
    打印產品信息
    貨號: ABE208
    品牌: Millipore
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      • Description
        CatalogueNumberABE208
        Replaces04-1002
        DescriptionAnti-β-CateninAntibody
        AlternateNames
        • catenin(cadherin-associatedprotein),beta1,88kDa
        • catenin(cadherin-associatedprotein),beta1(88kD)
        BackgroundInformationβ-cateninisthefoundingmemberoftheβ-cateninfamily.Thisproteiniscomprisedof12ARMrepeatsandisconsideredtohavedualfunctiondependingonitslocalization.Cytoplasmicβ-cateninisacriticalcomponentofE-cadherin/cateningadhesioncomplexesandisinvolvedinregulatingcadherin-dependentcell-cellinteractions.Whenlocalizedtothenucleus,β-cateninservesaregulatoryrolebybindingwithtranscriptionfactorsfromtheTCF/LEFfamily,activatingtranscription.Expressionofβ-cateninhasbeenreportedinavarietyofhairfolliclecellssuchascellsfoundintheinnerandouterportionsoftherootsheaths,andthebasalandperipheralmatrixcells.Ithasalsobeenobservedincolontissue.Defectsinexpressionhavebeenlinkedtothedevelopmentofseveraltumorsandcancerssuchas;colorectalcancer(CRC),medulloblastoma(MDB),ovariancancer(OC),andpilomatrixoma(PTR).
        ProductInformation
        FormatAffinityPurified
        Control
        • A431celllysate
        PresentationPurifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide.
        StorageandShippingInformation
        StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
        Applications
        ApplicationAnti-β-CateninAntibodyisaRabbitPolyclonalAntibodyfordetectionofβ-Cateninalsoknownascatenin(cadherin-associatedprotein)beta1(88kD)&hasbeenvalidatedinWB,ICC&IP.
        KeyApplications
        • WesternBlotting
        • Immunocytochemistry
        • Immunoprecipitation
        ApplicationNotesImmunoprecipitationAnalysis:10μgfromarepresentativelotimmunoprecipitatedβ-CateninfromA431lysate.

        ImmunocytochemistryAnalysis:1:500dilutionfromarepresentativelotdetectedβ-CatenininNIH/3T3andA431cells.
        BIOLOGicalInformation
        ImmunogenKLH-conjugatedlinearpeptidecorrespondingtotheconsensusGSK3phosphorylationsiteofhumanβ-Catenin.
        EpitopeConsensusGSK3phosphorylationsiteofhumanβ-Catenin
        ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
        HostRabbit
        SpecificityAntibodyrecognizesβ-CateninattheN-terminus.
        SpeciesReactivity
        • Human
        • Mouse
        • Rat
        • Horse
        • Ox
        SpeciesReactivityNoteDemonstratedtoreactwithhuman,mouse,andrat.Predictedtoreactwithequineandoxbasedon100%sequencehomology.
        AntibodyTypePolyclonalAntibody
        EntrezGeneNumber
        EntrezGeneSummaryTheproteinencodedbythisgeneispartofacomplexofproteinsthatconstituteadherensjunctions(AJs).AJsarenecessaryforthecreationandmaintenanceofepithelialcelllayersbyregulatingcellgrowthandadhesionbetweencells.TheencodedproteinalsoanchorstheactinCytoskeletonandmayberesponsIBLefortransmittingthecontactinhibitionsignalthatcausescellstostopdividingoncetheepithelialsheetiscomplete.Finally,thisproteinbindstotheproductoftheAPCgene,whichismutatedinadenomatouspolyposisofthecolon.Mutationsinthisgeneareacauseofcolorectalcancer(CRC),pilomatrixoma(PTR),medulloblastoma(MDB),andovariancancer.Threetranscriptvariantsencodingthesameproteinhavebeenfoundforthisgene.
        GeneSymbol
        • CTNNB1
        • CTNNB
        • Beta-catenin
        • PRO2286
        PurificationMethodAffinityPurfied
        UniProtNumber
        UniProtSummaryFUNCTION:InvolvedintheregulationofcelladhesionandinsignaltransductionthroughtheWntpathway.

        SIZE:781aminoacids;85497Da

        SUBUNIT:Twoseparatepoolsarefoundinthecytoplasm:oneisPSEN1/cadherin/catenincomplexwhichanchorstotheactincytoskeleton.TheotherpoolispartofalargecomplexcontainingAXIN1,AXIN2,APC,CSNK1A1andGSK3BthatpromotesphosphorylationonN-terminalSerandThrresiduesandubiquitinationofCTNNB1viaBTRCanditssubsequentdegradationbytheproteasome.Wnt-dependentactivationofDVLantagonizestheactionofGSK3B.WhenGSK3Bactivityisinhibitedthecomplexdissociates,CTNNB1isdephosphorylatedandisnolongertargetedfordestruction.ThestABIlizedproteintranslocatestothenucleus,whereitbindsTCF/LEF-1familymembers,TBP,BCL9andpossiblyalsoRUVBL1andDUPLIN.BindsCTNNBIPandEP300.CTNNB1formsaternarycomplexwithLEF1andEP300thatisdisruptedbyCTNNBIP1binding(Bysimilarity).InteractswiththePDZdomainofTAX1BP3;thisinteractioninhibitsthetranscriptionalactivityofCTNNB1(Bysimilarity).InteractswithAJAP1,BAIAP1,CARM1,CTNNA3,CXADRandPCDH11Y.BindsSLC9A3R1.InteractswithGLIS2.InteractswithSLC30A9(Bysimilarity).

        SUBCELLULARLOCATION:Cytoplasm.Nucleus.Note=Cytoplasmicwhenitisunstabilized(highlevelofphosphorylation)orboundtoCDH1.Translocatestothenucleuswhenitisstabilized(lowlevelofphosphorylation).InteractionwithGLIS2promotesnucleartranslocation.

        TISSUESPECIFICITY:Expressedinseveralhairfolliclecelltypes:basalandperipheralmatrixcells,andcellsoftheouterandinnerrootsheats.Expressedincolon.

        PTM:PhosphorylationbyGSK3BrequirespriorphosphorylationofSer-45byanotherkinase.PhosphorylationproceedsthenfromThr-41toSer-37andSer-33.&EGFstimulatestyrosinephosphorylation.PhosphorylationonTyr-654decreasesCDH1bindingandenhancesTBPbinding.&UbiquitinatedbyaE3ubiquitinligasecomplexcontainingUBE2D1,SIAH1,CACYBP/SIP,SKP1A,APCandTBL1X(Probable).Itsubiquitinationleadstoitssubsequentproteasomaldegradation.

        DISEASE:ActivatingmutationsinCTNNB1haveoncogenicactivityresultingintumordevelopment.Somaticmutationsarefoundinvarioustumortypes,includingcoloncancers,ovarianandprostatecarcinomas,hepatoblastoma(HB),hepatocellularcarcinoma(HCC).HBsaremalignantembryonaltumorsmainlyaffectingyoungchildreninthefirstthreeyearsoflife.&DefectsinCTNNB1areacauseofpilomatrixoma(PTR)[MIM:132600];acommonbenignskintumor.&DefectsinCTNNB1areacauseofmedulloblastoma(MDB)[MIM:155255].MDBisamalignant,invasiveembryonaltumorofthecerebellumwithapreferentialmanifestationinchildren.&AchromosomalrearrangementinvolvingCTNNB1maybeacauseofsalivaryglandpleiomorphicadenomas(PA)[181030].Pleiomorphicadenomasarethemostcommonbenignepithelialtumorsofthesalivarygland.Translocationt(3;8)(p21;q12)withPLAG1."

        SIMILARITY:Belongstothebeta-cateninfamily.&Contains12ARMrepeats.
        MolecularWeight~86kDaobserved.
        PhysicochemicalInformation
        Dimensions
        MaterialsInformation
        MaterialsInformation
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