| Immunogen | GSTfusionproteinfromratstargazin,cytoplasmicdomain. |
| Host | Rabbit |
| Specificity | Stargazin[Stargazin-likeTARP(transmembraneAMPAreceptorregulatoryprotein)].ByWesternblottheantibodyrecognizesbandsat~35kDaand~55kDaonTritonsolublefractionofratbrain.TheantibodyreactsdominantlywithTARPgamma-8andweaklywithgamma-3andgamma-4.Stargazinisexpressedstronglyinthehippocampusandcerebellum. |
| SpeciesReactivity | |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | L-typecalciumchannelsarecomposedoffivesubunits.Theproteinencodedbythisgenerepresentsoneofthesesubunits,gamma,andisoneofseveralgammasubunitproteins.Itisanintegralmembraneproteinthatisthoughttostabilizethecalciumchannelinaninactive(closed)state.Thisproteinissimilartothemousestargazinprotein,mutationsinwhichhavebeenassociatedwithabsenceseizures,alsoknownaspetit-malorspike-waveseizures.ThisgeneisamemberoftheneuronalcalciumchannelgammasubunitgenesubfamilyofthePMP-22/EMP/MP20family. |
| GeneSymbol | - CACNG2
- stargazin
- MGC138504
- MGC138502
|
| PurificationMethod | ImmunoAffinityPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q9Y698#Thoughttostabilizethecalciumchannelinaninactivated(closed)state. SIZE:323aminoacids;35966Da SUBUNIT:TheL-typecalciumchanneliscomposedoffivesubunits:alpha-1,alpha-2/delta,betaandgamma.InteractswiththePDZdomainsofDLG4/PSD-95andDLG1/SAP97.MayinteractwithGOPC(Bysimilarity). SUBCELLULARLOCATION:Membrane;Multi-passmembraneprotein. TISSUESPECIFICITY:Brain. PTM:PhosphorylationofThr-321impairsinteractionwithDLG1andDLG4. SIMILARITY:SwissProt:Q9Y698##BelongstothePMP-22/EMP/MP20family.CACNGsubfamily. |