| Immunogen | SyntheticpeptidefromthephosphoSer40ofratTyrosineHydroxylase. | 
| Epitope | phospho-Ser40 | 
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. | 
| Host | Rabbit | 
| Specificity | TyrosineHydroxylase,phosphoSer40.Theantibodyrecognizesaproteinof60kDacorrespondingtoTHphosphorylatedatSer40.Dependingonbrainregionbeingstudied,proteinloadsanddetectionmethodsusedsomehighermolecularweightbandsmaybedetected. | 
| SpeciesReactivity |  | 
| SpeciesReactivityNote | Ratandmouse.Itisexpectedthattheantibodywillalsoreactwithhuman,porcine,quailandnon-humanprimatesduetosequencehomology(100%).Otherspecieshavenotbeentested. | 
| AntibodyType | PolyclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | Tyrosinehydroxylaseisinvolvedintheconversionoftyrosinetodopamine.Astherate-limitingenzymeinthesynthesisofcatecholamines,tyrosinehydroxylasehasakeyroleinthephysiologyofadrenergicneurons. | 
| GeneSymbol |  | 
| Modifications |  | 
| PurificationMethod | ImmunoAffinityPurified | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P07101#Playsanimportantroleinthephysiologyofadrenergicneurons. COFACTOR:Fe(2+)ion. SIZE:528aminoacids;58524Da TISSUESPECIFICITY:Mainlyexpressedinthebrainandadrenalglands. DISEASE:SwissProt:P07101#DefectsinTHarethecauseofautosomalrecessiveSegawasyndrome[MIM:605407];alsoknownasDOPA-responsivedystonia.Typically,itbeginsinchildhoodoradolescencewithprogressivedifficultyinwalkingand,insomecases,spasticity.Somecasespresentwithparkinsoniansymptomsininfancyandarereferredtoasautosomalrecessiveinfantileparkinsonism. SIMILARITY:SwissProt:P07101##Belongstothebiopterin-dependentaromaticaminoacidhydroxylasefamily. | 
| MolecularWeight | 60kDa |