| Immunogen | Syntheticpeptide. |
| Host | Rabbit |
| Specificity | RecognizesHES-1(Hairyfamily),aHelix-loop-helixclassoftranscriptionfactor. |
| SpeciesReactivity | |
| SpeciesReactivityNote | Humanandrodent.Reactivitywithotherspecieshasnotbeenconfirmed. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisproteinbelongstothebasichelix-loop-helixfamilyoftranscriptionfactors.ItisatranscriptionalrepressorofgenesthatrequireabHLHproteinfortheirtranscription.TheproteinhasaparticulartypeofbasicdomainthatcontainsahelixinterruptingproteinthatbindstotheN-boxratherthanthecanonicalE-box. |
| GeneSymbol | - HES1
- Hes1
- HL
- HHL
- FLJ20408
- HRY
- HES-1
|
| PurificationMethod | ImmunoAffinityPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q14469#TranscriptionalrepressorofgenesthatrequireabHLHproteinfortheirtranscription.MayactasanegativeregulatorofmyogenesisbyinhibitingthefunctionsofMYOD1andASH1(Bysimilarity). SIZE:280aminoacids;29541Da SUBUNIT:Transcriptionrepressionrequiresformationofacomplexwithacorepressorprotein(Groucho)suchasTLE2(Bysimilarity).InteractswithSIRT1. SUBCELLULARLOCATION:Nucleus. DOMAIN:SwissProt:Q14469Hasaparticulartypeofbasicdomain(presenceofahelix-interruptingproline)thatbindstotheN-box(CACNAG),ratherthanthecanonicalE-box(CANNTG).&TheC-terminalWRPWmotifisatranscriptionalrepressiondomainnecessaryfortheinteractionwithGroucho,atranscriptionalcorepressorrecruitedtospecifictargetDNAbyHairy-relatedproteins. SIMILARITY:Contains1basichelix-loop-helix(bHLH)domain.&Contains1Orangedomain....hide?seemore? |
| MolecularWeight | 29kDa |