| Immunogen | Fulllengthrecombinantratalpha-internexinfusedtoE.coliTrpE. |
| Host | Rabbit |
| Specificity | alpha-internexin,C-terminalglobular"tail"region.Bywesternblot,AB5354detectsamajorbandat66kDaandaminorbandatapproximately150kDacorrespondingtoalphainternexinmonomeranddimer,respectively.Aminorbandatapproximately50kDaisoccasionallydetectedandisbelievedtobeadegradationproductofalphainternexin.ThisantibodyhasbeenreferredtointheliteratureastheR36antibody(Evans,2002). |
| SpeciesReactivity | |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| GeneSymbol | - INA
- NF-66
- NEF5
- MGC12702
- Alpha-Inx
- TXBP-1
- Neurofilament-66
- Alpha-internexin
|
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q16352#Class-IVneuronalintermediatefilamentthatisabletoself-assemble.Itisinvolvedinthemorphogenesisofneurons.ItmayformanindependentstructuralnetworkwithouttheinvolvementofotherneurofilamentsoritmaycooperatewithNF-LtoformthefilamentousbackbonetowhichNF-MandNF-Hattachtoformthecross-bridges. SIZE:499aminoacids;55391Da TISSUESPECIFICITY:FoundpredominantlyinadultCNS. DEVELOPMENTALSTAGE:Expressedinbrainasearlyasthe16thweekofgestation,andincreasedrapidlyandreachedasteadystatelevelbythe18thweekofgestation. PTM:O-glycosylated(Bysimilarity).&PhosphorylateduponDNAdamage,probablybyATMorATR. SIMILARITY:SwissProt:Q16352##Belongstotheintermediatefilamentfamily. |