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    當前位置 ： Millipore >>> Millipore/AB5320 | Anti-NG2 Chondroitin Sulfate Proteoglycan Antibody/AB5320/100 µg
    Millipore/AB5320 | Anti-NG2 Chondroitin Sulfate Proteoglycan Antibody/AB5320/100 µg
    • Millipore/AB5320 | Anti-NG2 Chondroitin Sulfate Proteoglycan Antibody/AB5320/100 µg

    Millipore/AB5320 | Anti-NG2 Chondroitin Sulfate Proteoglycan Antibody/AB5320/100 µg

    價格: ￥4440.00 市場價: 7400.00
    打印產品信息
    貨號: AB5320
    品牌: Millipore
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      • Description
        CatalogueNumberAB5320
        BrandFamilyChemicon®
        TradeName
        • Chemicon
        DescriptionAnti-NG2ChondroitinSulfateProteoglycanAntibody
        AlternateNames
        • ChondroitinsulfateproteoglycanNG2
        • Melanomachondroitinsulfateproteoglycan3
        • Melanoma-associatedchondroitinsulfateproteoglycan
        • chondroitinsulfateproteoglycan4
        • chondroitinsulfateproteoglycan4(melanoma-associated)
        BackgroundInformationNG2(alsoknownasChondroitinsulfateproteoglycan4,ChondroitinsulfateproteoglycanNG2,Melanomachondroitinsulfateproteoglycan,andMelanoma-associatedchondroitinsulfateproteoglycanis)ahighmolecularweight,integralmembranechondroitinsulfateproteoglycan.Itisfoundonthesurfacesofanunusualclassofglialcellswithinthedevelopingandmaturecentralnervoussystemthathavethepropertiesofoligodendrocyteprecursorcells(i.e.,O-2AProgenitorcells).NG2isalsofoundonthesurfacesofchondroblasts,proliferatingcapillaryendothelialcells,somehumanmelanomacelllines,andonleukemicblastsinchildhoodacutelymphoblasticleukemia.TheNG2proteoglycanislikelytoplayaroleinregulationofcellmotility,axonoutgrowthandthecellularresponsestoplatelet-derivedgrowthfactor.
        ProductInformation
        FormatAffinityPurified
        Control
        • Humanmelanoma,gliomaandproliferatingbrainendothelialcells,ratB49glialcellextractsorembryonicmousebraintissue.
        PresentationPurifiedrabbitpolyclonalinPBSbuffercontaining0.02%azide.
        StorageandShippingInformation
        StorageConditionsStablefor6monthsat-20oCinundilutedaliquotsfromdateofreceipt.

        HandlingRecommendations:
        Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
        Applications
        ApplicationDetectNG2ChondroitinSulfateProteoglycanusingthisAnti-NG2ChondroitinSulfateProteoglycanAntibodyvalidatedforuseinELISA,IC,IH,IPandWB.
        KeyApplications
        • ELISA
        • Immunocytochemistry
        • Immunohistochemistry
        • Immunoprecipitation
        • WesternBlotting
        ApplicationNotesImmunocytochemistry:
        A1:150-1:600dilutionofapreviouslotwasusedinIC.

        Immunohistochemistry:
        1:200dilutionofapreviouslotwasusedonfrozensectionsofembryonicmousebrainusinganAlexaFluorconjugatedsecondaryantibody.Careshouldbetakentoavoidoverfixingtissuesections.Ashort(5-10minute)fixin2-4%PFAisrecommended.

        Immunoprecipitation:
        2μg/mLconcentrationofapreviouslotwasusedinIP.

        ELISA:
        A1:1,500-1:3,000dilutionofapreviouslotwasusedinELISA.

        Optimalworkingdilutionsandprotocolsmustbedeterminedbyenduser
        BIOLOGicalInformation
        ImmunogenImmunoaffinitypurifiedNG2ChondroitinSulfateProteoglycanfromrat.
        ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
        HostRabbit
        SpecificityNG2ChondroitinSulfateProteoglycan.AB5320identifiesboththeintactproteoglycanandthecoreproteinbyWesternblotandELISA.Whenoligodendrocyteprecursorcells(i.e.O-2Aprogenitorcells)arestainedalive,thestainappearsasclustersonthecellsurface.Thisantibodydoesnotstaindifferentiatedoligodendrocyteswell.
        SpeciesReactivity
        • Human
        • Mouse
        • Rat
        • Monkey
        AntibodyTypePolyclonalAntibody
        EntrezGeneNumber
        EntrezGeneSummaryAhumanmelanoma-associatedchondroitinsulfateproteoglycanplaysaroleinstABIlizingcell-substratuminteractionsduringearlyeventsofmelanomacellspreADIngonendothelialbasementmembranes.CSPG4representsanintegralmembranechondroitinsulfateproteoglycanexpressedbyhumanmalignantmelanomacells.
        GeneSymbol
        • CSPG4
        • MSK16
        • MCSP
        • NG2
        • MCSPG
        • MEL-CSPG
        • HMW-MAA
        PurificationMethodAntibodypurifiedbyproteinA,thenplacedoverafibronectinaffinitycolumn.
        UniProtNumber
        UniProtSummaryFUNCTION:SwissProt:Q6UVK1#Proteoglycanplayingaroleincellproliferationandmigrationwhichstimulatesendothelialcellsmotilityduringmicrovascularmorphogenesis.Mayalsoinhibitneuriteoutgrowthandgrowthconecollapseduringaxonregeneration.Cellsurfacereceptorforcollagenalpha2(VI)whichmayconfercellsabilitytomigrateonthatsubstrate.BindsthroughitsextracellularN-terminusgrowthfactors,extracellularmatrixproteasesmodulatingtheiractivity.MayregulateMPP16-dependentdegradationandinvasionoftypeIcollagenparticipatinginmelanomacellsinvasionproperties.Maymodulatetheplasminogensystembyenhancingplasminogenactivationandinhibitingangiostatin.FunctionsalsoasasignaltransducingproteinbybindingthroughitscytoplasmicC-terminusscaffoldingandsignalingproteins.MaypromoteretractionfiberformationandcellpolarizationthroughRhoGTPaseactivation.Maystimulatealpha-4,beta-1integrin-mediatedadhesionandspreadingbyrecruitingandactivatingasignalingcascadethroughCDC42,ACK1andBCAR1.MayactivateFAKandERK1/ERK2signalingcascades.
        SIZE:2322aminoacids;250497Da
        SUBUNIT:InteractswiththefirstPDZdomainofMPDZ.InteractswithPRKCA.BindsTNC,laminin-1,COL5A1andCOL6A2.InteractswithPLGandangiostatin.BindsFGF2andPDGFA.InteractswithGRIP1,GRIP2andGRIA2.FormsaternarycomplexwithGRIP1andGRIA2(Bysimilarity).InteractswithLGALS3andtheintegrincomposedofITGB1andITGA3.InteractswithITGA4throughitschondroitinsulfateglycosaminoglycan.InteractswithBCAR1,CDC42andACK1.InteractswithMMP16.
        SUBCELLULARLOCATION:Apicalcellmembrane;Single-passtypeImembraneprotein(Bysimilarity).Cellprojection,lamellipodium(Bysimilarity).Note=LocalizedattheapicalplasmamembraneitrelocalizestothelamellipodiaofastrocytomauponphosphorylationbyPRKCA.Localizestotheretractionfibers.Localizestotheplasmamembraneofoligodendrocytes(Bysimilarity).
        TISSUESPECIFICITY:Detectedonlyinmalignantmelanomacells.
        PTM:N-glycosylated(Bysimilarity).&O-glycosylated;containsglycosaminoglycanchondroitinsulfatewhicharerequiredforproperlocalizationandfunctioninstressfiberformation(Bysimilarity).InvolvedininteractionwithMMP16andITGA4.&PhosphorylationbyPRKCAregulatesitssubcellularlocationandfunctionincellmotility(Bysimilarity).
        SIMILARITY:SwissProt:Q6UVK1##Contains15CSPG(NG2)repeats.&Contains2lamininG-likedomains.
        MISCELLANEOUS:ValuableMarkerforseveralincompletelydifferentiatedprecursorcells
        MolecularWeight270-300kDa
        PhysicochemicalInformation
        Dimensions
        MaterialsInformation
        MaterialsInformation
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