| Immunogen | RecombinantratGAP-43(completesequence). |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | RecognizesGrowthAssociatedProtein-43(GAP-43). |
| SpeciesReactivity | - Human
- Mouse
- Rat
- Chicken
- Bovine
|
| SpeciesReactivityNote | Reactstoahighdegreewithmouse.Reactstoalesserdegreewithrat,human,bovineandchicken.Otherspecieshavenotbeentested. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Theproteinencodedbythisgenehasbeentermeda"growth"or"plasticity"proteinbecauseitisexpressedathighlevelsinneuronalgrowthconesduringdevelopmentandaxonalregeneration.Thisencodedproteinisconsideredacrucialcomponentofaneffectiveregenerativeresponseinthenervoussystem. |
| GeneSymbol | |
| PurificationMethod | AmmoniumSulfatePrecipitation |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P17677#Thisproteinisassociatedwithnervegrowth.Itisamajorcomponentofthemotilegrowthconesthatformthetipsofelongatingaxons. SIZE:238aminoacids;24803Da SUBUNIT:BindscalmodulinwithagreateraffinityintheabsenceofCa(2+)thaninitspresence(Bysimilarity). SUBCELLULARLOCATION:Cellmembrane;Peripheralmembraneprotein;Cytoplasmicside.Cellprojection,growthconemembrane;Peripheralmembraneprotein;Cytoplasmicside.Celljunction,synapse.Note=Cytoplasmicsurfaceofgrowthconeandsynapticplasmamembranes. PTM:PhosphorylationofthisproteinbyaproteinkinaseCisspecificallycorrelatedwithcertainformsofsynapticplasticity. SIMILARITY:SwissProt:P17677##Belongstotheneuromodulinfamily.&Contains1IQdomain. |
| MolecularWeight | 23.6kDa |