| Immunogen | A22aminoacidpeptidesequencemappingtothe1stextracellulardomainofratNET. |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | SpecificforNorepinephrineTransporter(NET).NorepinephrineTransporterisa617aminoacidlongintegralmembraneproteinbelongingtotheSodium:NeurotransmitterSymporterfamily(Brussetal.1995;Melikianetal.1994;Pacholczyketal.1991)Theimmunogenpeptideshowsnosignificanthomologywithotherotherknownproteins. |
| SpeciesReactivity | |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | TheSLC6A2geneencodesanorepinephrine(noradrenaline)transporter,whichisresponsIBLeforreuptakeofnorepinephrineintopresynapticnerveterminalsandisaregulatorofnorepinephrinehomeostasis(Kimetal.,2006[PubMed17146058]).[suppliedbyOMIM] |
| GeneSymbol | |
| PurificationMethod | ImmunoAffinityPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P23975#Aminetransporter.Terminatestheactionofnoradrenalinebyitshighaffinitysodium-dependentreuptakeintopresynapticterminals. SIZE:617aminoacids;69332Da SUBUNIT:InteractswithPRKCABP. SUBCELLULARLOCATION:Membrane;Multi-passmembraneprotein. DISEASE:SwissProt:P23975#DefectsinSLC6A2areacauseoforthostaticintolerance(OI)[MIM:604715].OIisasyndromecharacterizedbylightheadedness,fatigue,alteredmentationandsyncope.Itisassociatedwithposturaltachycardia.Plasmanorepinephrineconcentrationisabnormallyhigh. SIMILARITY:SwissProt:P23975##Belongstothesodium:neurotransmittersymporter(SNF)family. MISCELLANEOUS:Thisproteinisthetargetofpsychomotorstimulantssuchasamphetaminesorcocaine. |
| MolecularWeight | 80&54kDa |