| Immunogen | Syntheticpeptidefromthecarboxy-terminusoftheclonedratserotonintransporter. |
| Host | GuineaPig |
| Specificity | SerotoninTransporter.Theantiserumhasbeentestedontissuesectionsfromthecentralnervoussystem.ThestainingpatternobtainedwiththeAB1772correspondstothepatterndescribedusingantiserumtoserotoninitself.Theserotonintransporterimmunoreactivitycorrespondstowhathasbeendescribedusingotherantibodiestotheserotonintransporter.Preabsorptionoftheantiserumwiththeimmunogenpeptidecompletelyabolishestheimmunostaining. |
| SpeciesReactivity | |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesanintegralmembraneproteinthattransportstheneurotransmitterserotoninfromsynapticspacesintopresynapticneurons.Theencodedproteinterminatestheactionofserotoninandrecyclesitinasodium-dependentmanner.Thisproteinisatargetofpsychomotorstimulants,suchasamphetaminesandcocaine,andisamemberofthesodium:neurotransmittersymporterfamily.Arepeatlengthpolymorphisminthepromoterofthisgenehasbeenshowntoaffecttherateofserotoninuptakeandmayplayaroleinsuddeninfantdeathsyndrome,aggressivebehaviorinAlzheimerdiseasepatients,anddepression-susceptibilityinpeopleexperiencingemotionaltrauma. |
| GeneSymbol | - SLC6A4
- 5-HTT
- 5HTT
- HTT
- OCD1
- hSERT
- SERT
|
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P31645#Terminatestheactionofserotoninbyitshighaffinitysodium-dependentreuptakeintopresynapticterminals. SIZE:630aminoacids;70325Da SUBUNIT:InteractswithTGFB1I1. SUBCELLULARLOCATION:Membrane;Multi-passmembraneprotein. SIMILARITY:SwissProt:P31645##Belongstothesodium:neurotransmittersymporter(SNF)family. MISCELLANEOUS:Thisproteinisthetargetofpsychomotorstimulantssuchasamphetaminesorcocaine. |