| Immunogen | Electrophoreticallypuretrp-E-peripherinfusionprotein[Dev.BrainRes.(1990)57:235-248],containingallbutthe4Nterminalaminoacidsofratperipherin.FusionproteinpurifiedfrombacterialinclusionbodiesbyDEAE-cellulosechromatographyin6MureafollowedbypreparativeSDS-PAGE. |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | RecognizesPeripherin.Theantibodystainsa~57kDabandcleanlyandspecificallyanddoesnotstainvimentin,GFAP,alpha-internexinoranyoftheneurofilamentsubunits.Strongstainingonrat,mouse,human,pigandcowperipherin.Doesnotstainchicken,quailorothermoredistantlyrelatedspecieswhichappeartolackperipherin. |
| SpeciesReactivity | |
| SpeciesReactivityNote | Strongstainingonratandhuman.Cross-reactswithmouse,pig,andbovine.Otherspeciesnottested. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesacytoskeletalproteinfoundinneuronsoftheperipheralnervoussystem.TheencodedproteinisatypeIIIintermediatefilamentproteinwithhomologytoothercytoskeletalproteinssuchasdesmin,andisadifferentproteinthattheperipherinfoundinphotoreceptors.Mutationsinthisgenehavebeenassociatedwithsusceptibilitytoamyotrophiclateralsclerosis. |
| GeneSymbol | - PRPH
- Peripherin
- PRPH1
- peripherin
- NEF4
|
| PurificationMethod | Unpurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P41219#Class-IIIneuronalintermediatefilamentprotein. SIZE:470aminoacids;53651Da SIMILARITY:SwissProt:P41219##Belongstotheintermediatefilamentfamily. |
| MolecularWeight | 56-58kDa |