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    當前位置 ： Millipore >>> Millipore/17-10246 | ChIPAb+? Histone H2A.Bbd - ChIP Validated Antibody and Primer Set/17-10246/25 assays25 assays per s
    Millipore/17-10246 | ChIPAb+? Histone H2A.Bbd - ChIP Validated Antibody and Primer Set/17-10246/25 assays25 assays per s
    • Millipore/17-10246 | ChIPAb+? Histone H2A.Bbd - ChIP Validated Antibody and Primer Set/17-10246/25 assays25 assays per s

    Millipore/17-10246 | ChIPAb+? Histone H2A.Bbd - ChIP Validated Antibody and Primer Set/17-10246/25 assays25 assays per s

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    貨號: 17-10246
    品牌: Millipore
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      • Description
        CatalogueNumber17-10246
        TradeName
        • ChIPAb+
        • Upstate
        DescriptionChIPAb+?HistoneH2A.BBD-ChIPValidatedAntibodyandPrimerSet
        OverviewAllChIPAb+antibodiesareindividuallyvalidatedforchromatinprecipitation,everylot,everytime.EachChIPAb+antibodysetincludescontrolprimers(testedeverylotbyqPCR)toBIOLOGicallyvalidateyourIPresultsinalocus-specificcontext.TheqPCRprotocolandprimersequencesareprovided,allowingresearcherstovalidateChIPprotocolswhenusingourantibodyintheirchromatincontext.EachsetalsoincludesanegativecontrolantibodytoensurespecificityoftheChIPreaction.
        TheChIPAb+HistoneH2A.BbdsetincludestheHistoneH2A.Bbdantibody,aNormalRabbitIgG,andcontrolprimerswhichamplifya70bpregionofChIPprimers,PGK1.TheHistoneH2A.Bbdandnegativecontrolsaresuppliedinascalable"perChIP"reactionsizeandcanbeusedtofunctionallyvalidatetheprecipitationofHistoneH2A.Bbd-associatedchromatin.
        AlternateNames
        • H2Ahistonefamily,memberB1
        • H2ABarrbody-deficient
        • histoneH2A-Bbdtype1
        BackgroundInformationHistoneH2A.Bbd(Barrbody-deficient),alsoknownashistoneH2A-Bbdtype1,isanatypicalhistonevariant.ThishistonevariantassociateswithH2BandreplaceshistoneH2Ainthenucleosome.IncontrasttootherH2Ahistones,thisvariantlacksconservedresiduesthataretargetsofpost-translationalmodifications.ConsequentlythisH2A.Bbdvariantisabout15aminoacidsshorterandonly48%similartothecanonicalH2A.ThemajordifferencesbetweenthetwoarefoundinthedockingdomainthatlinksH2A-H2BtotheH3-H4tetramer.Nucleosomescontainingthishistoneadoptamorerelaxedstructureandprotect~118basepairsofDNAinsteadofthe147basepairsfoundinclassicalnucleosomes.ThisvarianthistoneisassociatedwithactiveXchromosomesandautosomes,andistypicallyabsentfrominactiveXchromosomes.
        ProductInformation
        FormatAffinityPurified
        Control
        • IncludesnormalrabbitIgGandprimersspecificforhumanPGK1.
        PresentationAnti-HistoneH2A.Bbd(rabbitpolyclonal).Onevialcontaining100μgofpurifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazidebeforetheadditionof30%glycerol.Storeat-20°C
        Concentration:0.7mg/mL
        NormalRabbitIgG,.Onevialcontaining125μgofRabbitIgGin125μLofstoragebuffercontaining0.05%sodiumazide.Storeat-20°C.
        ChIPprimers,PGK1.Onevialcontaining75μLof5μMofeachprimerspecificforhumanPGK1.Storeat-20°C.
        FOR:CCTTCCCCCACGCTCCTA
        REV:TTGTGCAGGAACCTGTGAGATG
        StorageandShippingInformation
        StorageConditionsStablefor1yearat-20°Cfromdateofreceipt.HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
        Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.
        Applications
        ApplicationThisChIPAb+HistoneH2A.Bbd-ChIPValidatedAntibody&PrimerSetconvenientlyincludestheantibody&thespecificcontrolPCRprimers.
        KeyApplications
        • ElectrophoreticMobilityShiftAssay
        • Immunohistochemistry
        • Immunoprecipitation
        • WesternBlotting
        • ChromatinImmunoprecipitation(ChIP)
        ApplicationNotesWesternBlotAnalysis:
        Representativelotdata.
        H2A.Bbdoverexpression(Lane1-2),variousrecombinantHistoneproteins(Lane4-7)andHeLaacidextract(Lane8)lysateswereprobedwithAnti-HistoneH2A.Bbd(0.5μg/mL);
        Lane1:500ngofH2A.Bbdoverexpressionlysate
        Lane2:1μgH2A.Bbdoverexpressionlysate
        Lane3:500ngVectortransfectedcelllysatecontrol
        Lane4:500ngRecombinantHistoneH2A(Cat.#:14-493)
        Lane5:500ngRecombinantHistoneH2B(Cat.#:14-491)
        Lane6:500ngRecombinantHistoneH3(Cat.#:14-494)
        Lane7:500ngRecombinantHistoneH4(Cat.#:14-697)
        Lane8:10μgHeLaacidextract
        ProteinswerevisualizedusingaDonkeyAntiRabbitIgGsecondaryantibodyconjugatedtoHRPandachemiluminescencedetectionsystem.
        ArrowindicatesHistoneH2A.Bbd(~17kDa).(Figure2).
        BiologicalInformation
        ImmunogenKLH-conjugatedlinearpeptidecorrespondingtohumanHistoneH2A.Bbd.
        Epitopea.a.35-55
        ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
        HostRabbit
        SpecificityThisantibodyrecognizeshumanHistoneH2A.Bbd.
        SpeciesReactivity
        • Human
        • Mouse
        AntibodyTypePolyclonalAntibody
        EntrezGeneNumber
        EntrezGeneSummaryHistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Nucleosomesconsistofapproximately146bpofDNAwrappedaroundahistoneoctamercomposedofpairsofeachofthefourcorehistones(H2A,H2B,H3,andH4).Thechromatinfiberisfurthercompactedthroughtheinteractionofalinkerhistone,H1,withtheDNAbetweenthenucleosomestoformhigherorderchromatinstructures.ThisgeneencodesamemberofthehistoneH2Afamily.ThisgeneispartofaregionthatisrepeatedthreetimesonchromosomeX,onceinintron22oftheF8geneandtwiceclosertotheXqtelomere.Thisrecordrepresentsthemostcentromericcopywhichisinintron22oftheF8gene.[providedbyRefSeq].
        GeneSymbol
        • H2A.Bbd
        • H2AFB1
        PurificationMethodAffinityPurfied
        UniProtNumber
        UniProtSummaryFUNCTION:AtypicalhistoneH2AwhichcanreplaceconventionalH2Ainsomenucleosomes.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstability.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.Nucleosomescontainingthishistonearelessrigidandorganizeonly118basepairofDNAinsteadof147inclassicalnucleosomes.TheyareassociatedwithtranscriptionallyactivechromatinandexcludedformBarrbodies.Ref.4Ref.5

        SUBUNITSTRUCTURE:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Maybeincorporatedintoaproportionofnucleosomes,replacingoneormoreH2Amolecules.

        SUBCELLULARLOCATION:Nucleus.Chromosome.Note:AssociatedwiththeactiveXchromosomeandwithautosomes,whileitisabsentfromtheinactiveXchromosomeandexcludedfromBarrbodies.

        DOMAIN:ThedockingdomainisresponsiblefortheweakerheterodimerizationwithH2B.Ref.4

        MISCELLANEOUS:IncontrasttootherH2Ahistones,itdoesnotcontaintheconservedresiduesthatarethetargetofpost-translationalmodifications.

        SEQUENCESIMILARITIES:BelongstothehistoneH2Afamily.
        MolecularWeight~17kDaobserved
        PhysicochemicalInformation
        Dimensions
        MaterialsInformation
        MaterialsInformation
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