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    當前位置 ： Millipore >>> Millipore/16-202A | Anti-phospho-Histone H2A.X (Ser139) Antibody, clone JBW301, FITC conjugate/16-202A/100 µg
    Millipore/16-202A | Anti-phospho-Histone H2A.X (Ser139) Antibody, clone JBW301, FITC conjugate/16-202A/100 µg
    • Millipore/16-202A | Anti-phospho-Histone H2A.X (Ser139) Antibody, clone JBW301, FITC conjugate/16-202A/100 µg

    Millipore/16-202A | Anti-phospho-Histone H2A.X (Ser139) Antibody, clone JBW301, FITC conjugate/16-202A/100 µg

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    貨號: 16-202A
    品牌: Millipore
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      • Description
        CatalogueNumber16-202A
        BrandFamilyUpstate
        TradeName
        • Upstate
        DescriptionAnti-phospho-HistoneH2A.X(Ser139)Antibody,cloneJBW301,FITCconjugate
        AlternateNames
        • H2AXS139P
        • HistoneH2A.X(phosphoS139)
        • H2Ahistonefamily,memberX
        • H2AXhistone
        BackgroundInformationHistoneH2Aisoneofthe5mainhistoneproteinsinvolvedinthestructureofchromatinineukaryoticcells.FeaturingamainglobulardomainandalongNterminaltailH2Aisinvolvedwiththestructureofthenucleosomesofthe"beadsonastring"structure.
        ProductInformation
        FormatFITC
        Control
        • Staurosporine-treatedJurkatcells
        PresentationPurifiedFITC-conjugatedmousemonoclonalIgG1inbuffercontainingPBSwith0.05%sodiumazide.Frozensolution.
        StorageandShippingInformation
        StorageConditionsStablefor1yearatfromdateofreceipt.
        Applications
        ApplicationUseAnti-phospho-HistoneH2A.X(Ser139)Antibody,cloneJBW301,FITCconjugate(mousemonoclonalantibody)validatedinFC,ICCtodetectphospho-HistoneH2A.X(Ser139)alsoknownasH2AXS139P,H2AXhistone.
        KeyApplications
        • FlowCytometry
        • Immunocytochemistry
        ApplicationNotesImmunocytochemistry:2-4μg/mLofapreviouslotdetectedphospho-histoneH2A.Xinetoposide-treatedHeLacellsfixedwith95%ethanol/5%aceticacid(10minutes),followedby1%formaldehyde,0.25%Triton?X-100inTBS(5min.).
        BIOLOGicalInformation
        ImmunogenKLH-conjugated,syntheticpeptide(CKATQA[pS]QEY)correspondingtoaminoacids134-142ofhumanhistoneH2A.X.Theimmunizingsequencehas8identicalaminoacidsinyeastandmouse.CloneJBW301.
        EpitopeSer139
        ClonecloneJBW301
        ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
        HostMouse
        SpecificityRecognizesHistoneH2A.XphosphorylatedatSer139,MW15kDa.
        IsotypeIgG1
        SpeciesReactivity
        • Human
        SpeciesReactivityNoteHuman.
        Broadspeciescross-reactivityisexpectedbasedonconservationofsequencehomology.
        AntibodyTypeMonoclonalAntibody
        EntrezGeneNumber
        EntrezGeneSummaryHistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Twomoleculesofeachofthefourcorehistones(H2A,H2B,H3,andH4)formanoctamer,aroundwhichapproximately146bpofDNAiswrappedinrepeatingunits,callednucleosomes.Thelinkerhistone,H1,interactswithlinkerDNAbetweennucleosomesandfunctionsinthecompactionofchromatinintohigherorderstructures.ThisgeneencodesamemberofthehistoneH2Afamily,andgeneratestwotranscriptsthroughtheuseoftheconservedstem-loopterminationmotif,andthepolyAadditionmotif.
        GeneSymbol
        • H2AFX
        • H2AX
        • H2a/x
        • H2A/X
        • H2A.X
        Modifications
        • Phosphorylation
        PurificationMethodProteinGPurified
        UniProtNumber
        UniProtSummaryFUNCTION:SwissProt:P16104#VarianthistoneH2AwhichreplacesconventionalH2Ainasubsetofnucleosomes.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.Requiredforcheckpoint-mediatedarrestofcellcycleprogressioninresponsetolowdosesofionizingrADIationandforefficientrepairofDNAdoublestrandbreaks(DSBs)specificallywhenmodifiedbyC-terminalphosphorylation.
        SIZE:143aminoacids;15145Da
        SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA.InteractswithnumerousproteinsrequiredforDNAdamagesignalingandrepairwhenphosphorylatedonSer-140.TheseincludeMDC1,TP53BP1,BRCA1andtheMRNcomplex,composedofMRE11A,RAD50,andNBN.InteractionwiththeMRNcomplexismediatedatleastinpartbyNBN.AlsointeractswithDHX9/NDHIIwhenphosphorylatedonSer-140.
        SUBCELLULARLOCATION:Nucleus.DEVELOPMENTALSTAGE:SynthesizedinG1aswellasinS-phase.
        DOMAIN:SwissProt:P16104The[ST]-QmotifconstitutesarecognitionsequenceforkinasesfromthePI3/PI4-kinasefamily.
        PTM:PhosphorylatedonSer-140(toformgamma-H2AFX)inresponsetoDNAdoublestrandbreaks(DSBs)generatedbyexogenousgenotoxicagentsandbystalledreplicationforks,andmayalsooccurduringmeioticrecombinationeventsandimmunoglobulinclassswitchinginlymphocytes.PhosphorylationcanextenduptoseveralthousandnucleosomesfromtheactualsiteoftheDSBandmaymarkthesurroundingchromatinforrecruitmentofproteinsrequiredforDNAdamagesignalingandrepair.Widespreadphosphorylationmayalsoservetoamplifythedamagesignaloraidrepairofpersistentlesions.PhosphorylationofSer-140inresponsetoionizingradiationismediatedbybothATMandPRKDCwhiledefectsinDNAreplicationinduceSer-140phosphorylationsubsequenttoactivationofATRandPRKDC.DephosphorylationofSer-140byPP2AisrequiredforDNADSBrepair.Inmeiosis,Ser-140phosphorylationmayoccuratsynaptonemalcomplexesduringleptoteneasanATM-dependentresponsetotheformationofprogrammedDSBsbySPO11.Ser-140phosphorylationmaysubsequentlyoccursatunsynapsedregionsofbothautosomesandtheXYbivalentduringzygotene,downstreamofATRandBRCA1activation.Ser-140phosphorylationmayalsoberequiredfortranscriptionalrepressionofunsynapsedchromatinandmeioticsexchromosomeinactivation(MSCI),wherebytheXandYchromosomescondenseinpachytenetoformtheheterochromaticXY-body.Duringimmunoglobulinclassswitchrecombinationinlymphocytes,Ser-140phosphorylationmayoccuratsitesofDNA-recombinationsubsequenttoactivationoftheactivation-inducedcytidinedeaminaseAICDA.&MonoubiquitinationofLys-120byRING1andRNF2/RING2complexgivesaspecifictagforepigenetictranscriptionalrepression(Bysimilarity).
        SIMILARITY:BelongstothehistoneH2Afamily.
        MolecularWeight15kDa
        PhysicochemicalInformation
        Dimensions
        MaterialsInformation
        MaterialsInformation
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