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    當前位置 ： Millipore >>> Millipore/16-193 | Anti-phospho-Histone H2A.X (Ser139) Antibody, clone JBW301, biotin conjugate/16-193/100 µg
    Millipore/16-193 | Anti-phospho-Histone H2A.X (Ser139) Antibody, clone JBW301, biotin conjugate/16-193/100 µg
    • Millipore/16-193 | Anti-phospho-Histone H2A.X (Ser139) Antibody, clone JBW301, biotin conjugate/16-193/100 µg

    Millipore/16-193 | Anti-phospho-Histone H2A.X (Ser139) Antibody, clone JBW301, biotin conjugate/16-193/100 µg

    價格: ￥4680.00 市場價: 7800.00
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    貨號: 16-193
    品牌: Millipore
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      • Description
        CatalogueNumber16-193
        BrandFamilyUpstate
        TradeName
        • Upstate
        DescriptionAnti-phospho-HistoneH2A.X(Ser139)Antibody,cloneJBW301,biotinconjugate
        AlternateNames
        • H2AXS139P
        • HistoneH2A.X(phosphoS139)
        • H2Ahistonefamily,memberX
        • H2AXhistone
        BackgroundInformationHistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Nucleosomesconsistofapproximately146bpofDNAwrappedaroundahistoneoctamercomposedofpairsofeachofthefourcorehistones(H2A,H2B,H3,andH4).Thechromatinfiberisfurthercompactedthroughtheinteractionofalinkerhistone,H1,withtheDNAbetweenthenucleosomestoformhigherorderchromatinstructures.
        ProductInformation
        FormatBiotin
        Control
        • Staurosporine-treatedJurkatcelllysates.
        PresentationPurifiedbiotinconjugatedmousemonoclonalIgG1inbuffercontaining70%storagebuffer(0.02MPhosphatebuffer,pH7.6,0.25MNaCl,0.1%sodiumazide)and30%glycerol
        StorageandShippingInformation
        StorageConditionsStablefor1yearat-20oCfromdateofreceipt.
        HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.
        Applications
        ApplicationAnti-phospho-HistoneH2A.X(Ser139)Antibody,cloneJBW301,biotinconjugateisaMouseMonoclonalAntibodyfordetectionofphospho-HistoneH2A.X(Ser139)alsoknownasH2AXS139P,H2AXhistone&hasbeenvalidatedinICC&WB.
        KeyApplications
        • Immunocytochemistry
        • WesternBlotting
        BIOLOGicalInformation
        ImmunogenKLH-conjugated,syntheticpeptide(CKATQA[pS]QEY)correspondingtoaminoacids134-142ofhumanhistoneH2A.X.Theimmunizingsequencehas8identicalaminoacidsinyeastandmouse.
        EpitopeSer139
        CloneJBW301
        ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
        HostMouse
        SpecificityRecognizesHistoneH2A.XphosphorylatedatSer139,Mr15kDa.
        IsotypeIgG1
        SpeciesReactivity
        • Human
        SpeciesReactivityNoteHuman.Abroadspeciescross-reactivityisexpectedbasedonconservationofsequencehomology.
        AntibodyTypeMonoclonalAntibody
        EntrezGeneNumber
        EntrezGeneSummaryHistonesarebasicnuclearproteinsthatareresponsibleforthenucleosomestructureofthechromosomalfiberineukaryotes.Twomoleculesofeachofthefourcorehistones(H2A,H2B,H3,andH4)formanoctamer,aroundwhichapproximately146bpofDNAiswrappedinrepeatingunits,callednucleosomes.Thelinkerhistone,H1,interactswithlinkerDNAbetweennucleosomesandfunctionsinthecompactionofchromatinintohigherorderstructures.ThisgeneencodesamemberofthehistoneH2Afamily,andgeneratestwotranscriptsthroughtheuseoftheconservedstem-loopterminationmotif,andthepolyAadditionmotif.
        GeneSymbol
        • H2AFX
        • H2AX
        • H2a/x
        • H2A/X
        • H2A.X
        Modifications
        • Phosphorylation
        PurificationMethodProteinGPurified
        UniProtNumber
        UniProtSummaryFUNCTION:SwissProt:P16104#VarianthistoneH2AwhichreplacesconventionalH2Ainasubsetofnucleosomes.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstability.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.Requiredforcheckpoint-mediatedarrestofcellcycleprogressioninresponsetolowdosesofionizingrADIationandforefficientrepairofDNAdoublestrandbreaks(DSBs)specificallywhenmodifiedbyC-terminalphosphorylation.
        SIZE:143aminoacids;15145Da
        SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA.InteractswithnumerousproteinsrequiredforDNAdamagesignalingandrepairwhenphosphorylatedonSer-140.TheseincludeMDC1,TP53BP1,BRCA1andtheMRNcomplex,composedofMRE11A,RAD50,andNBN.InteractionwiththeMRNcomplexismediatedatleastinpartbyNBN.AlsointeractswithDHX9/NDHIIwhenphosphorylatedonSer-140.
        SUBCELLULARLOCATION:Nucleus.
        DEVELOPMENTALSTAGE:SynthesizedinG1aswellasinS-phase.
        DOMAIN:SwissProt:P16104The[ST]-QmotifconstitutesarecognitionsequenceforkinasesfromthePI3/PI4-kinasefamily.
        PTM:PhosphorylatedonSer-140(toformgamma-H2AFX)inresponsetoDNAdoublestrandbreaks(DSBs)generatedbyexogenousgenotoxicagentsandbystalledreplicationforks,andmayalsooccurduringmeioticrecombinationeventsandimmunoglobulinclassswitchinginlymphocytes.PhosphorylationcanextenduptoseveralthousandnucleosomesfromtheactualsiteoftheDSBandmaymarkthesurroundingchromatinforrecruitmentofproteinsrequiredforDNAdamagesignalingandrepair.Widespreadphosphorylationmayalsoservetoamplifythedamagesignaloraidrepairofpersistentlesions.PhosphorylationofSer-140inresponsetoionizingradiationismediatedbybothATMandPRKDCwhiledefectsinDNAreplicationinduceSer-140phosphorylationsubsequenttoactivationofATRandPRKDC.DephosphorylationofSer-140byPP2AisrequiredforDNADSBrepair.Inmeiosis,Ser-140phosphorylationmayoccuratsynaptonemalcomplexesduringleptoteneasanATM-dependentresponsetotheformationofprogrammedDSBsbySPO11.Ser-140phosphorylationmaysubsequentlyoccursatunsynapsedregionsofbothautosomesandtheXYbivalentduringzygotene,downstreamofATRandBRCA1activation.Ser-140phosphorylationmayalsoberequiredfortranscriptionalrepressionofunsynapsedchromatinandmeioticsexchromosomeinactivation(MSCI),wherebytheXandYchromosomescondenseinpachytenetoformtheheterochromaticXY-body.Duringimmunoglobulinclassswitchrecombinationinlymphocytes,Ser-140phosphorylationmayoccuratsitesofDNA-recombinationsubsequenttoactivationoftheactivation-inducedcytidinedeaminaseAICDA.&MonoubiquitinationofLys-120byRING1andRNF2/RING2complexgivesaspecifictagforepigenetictranscriptionalrepression(Bysimilarity).
        SIMILARITY:BelongstothehistoneH2Afamily.
        MolecularWeight15kDa
        PhysicochemicalInformation
        Dimensions
        MaterialsInformation
        MaterialsInformation
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