| Immunogen | SyntheticpeptideencompassingandincludingphosphorylatedTyr992ofhumanTIE2. | 
| Host | Rabbit | 
| Specificity | RecognizesTIE2/TEKphosphorylatedonTyr992. | 
| Isotype | IgG | 
| SpeciesReactivity |  | 
| SpeciesReactivityNote | Mouseandratexpectedtoreactbasedon100%homologyofimmunogen. | 
| AntibodyType | PolyclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | TheTEKreceptortyrosinekinaseisexpressedalmostexclusivelyinendothelialcellsinmice,rats,andhumans.Thisreceptorpossessesauniqueextracellulardomaincontaining2immunoglobulin-likeloopsseparatedby3epidermalgrowthfactor-likerepeatsthatareconnectedto3fibronectintypeIII-likerepeats.Theligandforthereceptorisangiopoietin-1.DefectsinTEKareassociatedwithinheritedvenousmalformations;theTEKsignalingpathwayappearstobecriticalforendothelialcell-smoothmusclecellcommunicationinvenousmorphogenesis.TEKiscloselyrelatedtotheTIEreceptortyrosinekinase. | 
| GeneSymbol | - TEK
 - CD202B
 - TIE2
 - VMCM1
 - VMCM
 - hTIE2
 - CD202b
 - TIE-2
 
  | 
| Modifications |  | 
| PurificationMethod | Doubleaffinitypurificationoverbothnon-phospho-peptidecolumnfollowedbyphopshorylatedpeptidecolumn. | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:Q02763#Thisproteinisaproteintyrosine-kinasetransmembranereceptorforangiopoietin1.ItmayconstitutetheearliestmammalianendothelialcelllineageMarker.Probablyregulatesendothelialcellproliferation,differentiationandguidestheproperpatterningofendothelialcellsduringbloodvesselformation. SIZE:1124aminoacids;125811Da SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. TISSUESPECIFICITY:PredominantlyexpressedinendothelialcellsandtheirProgenitors,theangioblasts.Hasbeendirectlyfoundinplacentaandlung,withalowerlevelinumbilicalveinendothelialcells,brainandkidney. DISEASE:SwissProt:Q02763#DefectsinTEKareacauseofdominantlyinheritedvenousmalformations(VMCM)[MIM:600195];anerrorofvascularmorphogenesischaracterizedbydilated,serpiginouschannels. SIMILARITY:SwissProt:Q02763##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.Tiesubfamily.&Contains3EGF-likedomains.&Contains3fibronectintype-IIIdomains.&Contains2Ig-likeC2-type(immunoglobulin-like)domains.&Contains1proteinkinasedomain. | 
| MolecularWeight | 145kDa |