| Immunogen | KLH-conjugatedlinearproteincorrespondingtohumanRBL2atandaroundtheC-terminus. | 
| Epitope | C-terminus | 
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. | 
| Host | Rabbit | 
| Specificity | ThisantibodyrecognizesRBL2atandaroundtheC-terminus. | 
| SpeciesReactivity |  | 
| SpeciesReactivityNote | Proventoreactwithhuman.Predictedtoreactwithrat,horse,chimpanzee,ape,anddogbasedonsequencehomology.Mouse(95%). | 
| AntibodyType | PolyclonalAntibody | 
| EntrezGeneNumber |  | 
| GeneSymbol | - RBL2
 - P130
 - PRB2
 - RB2
 - RBR-2
 - Rb2
 - p130
 
  | 
| PurificationMethod | AffinityPurfied | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:Keyregulatorofentryintocelldivision.Directlyinvolvedinheterochromatinformationbymaintainingoverallchromatinstructureand,inparticular,thatofconstitutiveheterochromatinbystABIlizinghistonemethylation.RecruitsandtargetshistonemethyltransferasesSUV420H1andSUV420H2,leADIngtoepigenetictranscriptionalrepression.ControlshistoneH4"Lys-20"trimethylation.Probablyactsasatranscriptionrepressorbyrecruitingchromatin-modifyingenzymestopromoters.PotentinhibitorofE2F-mediatedtrans-activation,associatespreferentiallywithE2F5.BindstocyclinsAandE.BindstoandmaybeinvolvedinthetransformingcapacityoftheadenovirusE1Aprotein.Mayactasatumorsuppressor.
  SIZE:1139aminoacids;128367Da
  SUBUNIT:InteractswithAATF.InteractswithSUV420H1andSUV420H2(Bysimilarity).InteractswithRINT1.
  SUBCELLULARLOCATION:Nucleus.
  PTM:DuringG0andearlyG1phaseofthecellcycle,phosphorylatedonSer-639andon5siteswithinthedomainB.PhosphorylationonSer-672inG1leadstoitsubiquitin-dependentproteolysis.
  SIMILARITY:Belongstotheretinoblastomaprotein(RB)family.
  MISCELLANEOUS:G0-restrictedexpression. | 
| MolecularWeight | 130kDa |