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    當前位置 : Millipore >>> Millipore/07-937 | Anti-HDAC7 Antibody/07-937/100 µL
    Millipore/07-937 | Anti-HDAC7 Antibody/07-937/100 µL
    • Millipore/07-937 | Anti-HDAC7 Antibody/07-937/100 µL

    Millipore/07-937 | Anti-HDAC7 Antibody/07-937/100 µL

    價格: ¥4680.00 市場價: 7800.00

    貨號: 07-937
    品牌: Millipore
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      • Description
        CatalogueNumber07-937
        DescriptionAnti-HDAC7Antibody
        AlternateNames
        • histonedeacetylase7
        • histonedeacetylase7A
        BackgroundInformationHistonedeacetylases(HDAC)areenzymesthatregulatestranscriptionbyselectivelydeacetylatingtheeta-aminogroupsoflysineslocatedneartheaminoterminiofcorehistoneproteins.EightmembersoftheHDACfamilyhavebeenidentified,dividedintotwoclasses.ClassIincludesHDAC-1,2,3and8whileClassIIincludesHDAC-4,5,6,and7.HumanHDAC7iscomposedof912aminoacidresidues.AlthoughHDAC7islocalizedmostlytothecellnucleus,itisalsofoundinthecytoplasm,suggestingnucleo-cytoplasmicshuttling.ThehistonedeacetylaseactivityofHDAC7mapstoaC-terminaldomainandisdependentoninteractionwithclassIHDACsinthenucleus.Itisanactivecomponentofdifferenttranscriptionalco-repressorcomplexesthatcanberecruitedtospecificpromoterregionsviainteractionswithtranscriptionfactors.HDAC7catalyzesremovalofacetyl-groupsfromacetyl-lysinesofhistones,resultinginatighterDNA-histoneinteraction.ThiscompactionofchromatinleadstotherepressionoftranscriptionofDNAinthatregion.
        ProductInformation
        FormatAffinityPurified
        Control
        • RecombinantHDAC7protein(Cat.#14-832).
        PresentationPurifiedRabbitpolyclonalinbuffercontaining20mMPBSand0.1%sodiumazide.
        StorageandShippingInformation
        StorageConditionsStablefor1yearat2-8oCfromdateofreceipt.
        Applications
        ApplicationUseAnti-HDAC7Antibody(RabbitPolyclonalAntibody)validatedinWBtodetectHDAC7alsoknownashistonedeacetylase7,histonedeacetylase7A.
        KeyApplications
        • WesternBlotting
        ApplicationNotesWesternBlotting:
        ApreviouslotofthisantibodywasshowntorecognizerecombinantHDAC7butnotrecombinantHDAC1,HDAC4,orHDAC8.

        WesternBlotting:
        ApreviouslotofthisantibodywasshowntorecognizeendogenousHDAC7inHEK293Tcells.
        BIOLOGicalInformation
        ImmunogenSyntheticpeptidecorrespondingtoaminoacids164-182ofhumanHDAC7[(C)KPKKSLERRKNPLLRKESA].
        Epitopea.a.164-182
        HostRabbit
        SpecificityThisantibodyrecognizeshumanHDAC7.Doesnotcross-reactwithHDAC1,HDAC4,orHDAC8.
        SpeciesReactivity
        • Human
        SpeciesReactivityNoteReactswithHuman.Nottestedwithotherspecies.
        AntibodyTypePolyclonalAntibody
        EntrezGeneNumber
        EntrezGeneSummaryHistonesplayacriticalroleintranscriptionalregulation,cellcycleprogression,anddevelopmentalevents.Histoneacetylation/deacetylationalterschromosomestructureandaffectstranscriptionfactoraccesstoDNA.Theproteinencodedbythisgenehassequencehomologytomembersofthehistonedeacetylasefamily.ThisgeneisorthologoustomouseHDAC7genewhoseproteinpromotesrepressionmediatedviathetranscriptionalcorepressorSMRT.Alternativelysplicedtranscriptvariantsencodingdifferentisoformshavebeenfoundforthisgene.[providedbyRefSeq].
        GeneSymbol
        • DKFZP586J0917
        • EC3.5.1.98
        • FLJ99588
        • HD7
        • HD7A
        • HD7a
        • HDAC7A
        PurificationMethodAffinityPurfied
        UniProtNumber
        UniProtSummaryFUNCTION:ResponsIBLeforthedeacetylationoflysineresiduesontheN-terminalpartofthecorehistones(H2A,H2B,H3andH4).Histonedeacetylationgivesatagforepigeneticrepressionandplaysanimportantroleintranscriptionalregulation,cellcycleprogressionanddevelopmentalevents.Histonedeacetylasesactviatheformationoflargemultiproteincomplexes.InvolvedinmusclematurationbyrepressingtranscriptionofmyocyteenhancerfactorssuchasMEF2A,MEF2BandMEF2C.Duringmuscledifferentiation,itshuttlesintothecytoplasm,allowingtheexpressionofmyocyteenhancerfactorsBysimilarity.MaybeinvolvedinEpstein-Barrvirus(EBV)latency,possiblybyrepressingtheviralBZLF1gene.

        CatalyticactivityHydrolysisofanN(6)-acetyl-lysineresidueofahistonetoyieldadeacetylatedhistone.

        SUBUNIT:InteractswithHDAC1,HDAC2,HDAC3,HDAC4,HDAC5,NCOR1,NCOR2,SIN3A,SIN3B,RBBP4,RBBP7,MTA1L1,SAP30andMBD3.Interactswiththe14-3-3proteinYWHAE,MEF2A,MEF2BandMEF2CBysimilarity.InteractswithHTATIPandEDNRA.InteractswithJARID1B.

        SUBCELLULARLOCATION:Nucleus.Cytoplasm.Note=Inthenucleus,itassociateswithdistinctsubnucleardot-likestructures.Shuttlesbetweenthenucleusandthecytoplasm.TreatmentwithEDN1resultsinshuttlingfromthenucleustotheperinuclearregion.Theexporttocytoplasmdependsontheinteractionwiththe14-3-3proteinYWHAEandmaybeduetoitsphosphorylation.

        DOMAIN:ThenuclearexportsequencemediatestheshuttlingbetweenthenucleusandthecytoplasmBysimilarity.

        PTM:MaybephosphorylatedbyCaMK1Bysimilarity.

        MISCELLANEOUS:ItsactivityisinhibitedbyTrichostatinA(TSA),aknownhistonedeacetylaseinhibitorBysimilarity.

        SIMILARITY:Belongstothehistonedeacetylasefamily.Type2subfamily.

        MolecularWeight100kDa
        PhysicochemicalInformation
        Dimensions
        MaterialsInformation
        MaterialsInformation
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