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    當前位置 ： Millipore >>> Millipore/07-371 | Anti-Histone H2B Antibody/07-371/200 µg
    Millipore/07-371 | Anti-Histone H2B Antibody/07-371/200 µg
    • Millipore/07-371 | Anti-Histone H2B Antibody/07-371/200 µg

    Millipore/07-371 | Anti-Histone H2B Antibody/07-371/200 µg

    價格: ￥4680.00 市場價: 7800.00
    打印產品信息
    貨號: 07-371
    品牌: Millipore
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      • Description
        CatalogueNumber07-371
        ReplacesMABE15
        BrandFamilyUpstate
        TradeName
        • Upstate
        DescriptionAnti-HistoneH2BAntibody
        AlternateNames
        • H2B
        • HistoneH2B
        • H2Bhistonefamily,memberQ
        • histone2
        • H2be
        • histonecluster2
        • H2be
        BackgroundInformationHistoneH2Btype3-B(UniProt:Q8N257;alsoknownasH2Btype12)isencodedbytheHIST3H2BBgene(GeneID:128312)inhuman.HistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofchromatinineukaryotes.Twomoleculesofeachofthefourcorehistones(H2A,H2B,H3,andH4)formanoctamer,aroundwhichDNAiswrappedinrepeatingunits,callednucleosomes,whichlimitsDNAaccessibilitytothecellularmachineries,whichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.HistoneH2Bisoneofthemainhistoneproteinsinvolvedinthestructureofchromatinineukaryoticcells.FeaturingamainglobulardomainandalongNterminaltail,H2Bisinvolvedwiththestructureofthenucleosomesofthe"beadsonastring"structure.HistoneH2BcanbemonoubiquitinatedonLysine123byRAD6/UBC2-BRE1complextoformH2BK123Ub1complexthatgivesaspecifictagforepigenetictranscriptionalactivationandisalsoaprerequisiteforH3K4meandH3K79meformation.H2BK123ub1isreportedtomodulatestheformationofdouble-strandbreaksduringmeiosisandisarequiredforDNA-damagecheckpointactivation.HistoneH2BisphosphorylatedbySTE20toformH2BS10phduringprogressionthroughmeioticprophaseandmaybecorrelatedwithchromosomecondensation.HistoneH2BcanundergoacetylationbyGCN5,acomponentoftheSAGAcomplex,toformH2BK11acandH2BK16ac.AcetylationofN-terminallysinesandparticularlyformationofH2BK11acK16achasapositiveeffectontranscription.
        ProductInformation
        FormatPurified
        Control
        • AcidextractfromeithersodiumbutyrateorcolcemidtreatedHeLacells.
        PresentationPurifiedrabbitpolyclonalantibodyinbuffercontaining0.02Mphosphatebuffer,pH7.6,0.25MNaCl,with0.1%sodiumazideand30%glycerol.
        StorageandShippingInformation
        StorageConditionsStablefor1yearat-20oCfromdateofreceipt.
        Applications
        ApplicationAnti-HistoneH2BAntibody,Cat.No.07-371,isahighlyspecificrabbitpolyclonalantibodythattargetsHistoneH2BandhasbeentestedinWesternBlotting.
        KeyApplications
        • WesternBlotting
        ApplicationNotesWesternBlottingAnalysis:1-2μg/mLfromarepresentativelotdetectedHistoneH2BinacidextractofHeLacellstreatedwitheithersodiumbutyrateorcolcemid.
        BIOLOGicalInformation
        ImmunogenKLH-conjugatedlinearpeptidecorrespondingto9aminoacidsfromtheC-terminusofhumanHistoneH2Btype3-B.
        ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
        HostRabbit
        SpecificityThisrabbitpolyclonalantibodydetectsHistoneH2Binhumanandchicken.Ittargetsanepitopewithin9aminoacidsfromtheC-terminusregion.
        IsotypeIgG
        SpeciesReactivity
        • Chicken
        • Human
        SpeciesReactivityNoteHuman,Chicken.PredictedtoreactwithYeast,Xenopusbasedon100%sequencehomology.
        AntibodyTypePolyclonalAntibody
        EntrezGeneNumber
        EntrezGeneSummaryHistonesarebasicnuclearproteinsthatareresponsibleforthenucleosomestructureofthechromosomalfiberineukaryotes.Nucleosomesconsistofapproximately146bpofDNAwrappedaroundahistoneoctamercomposedofpairsofeachofthefourcorehistones(H2A,H2B,H3,andH4).Thechromatinfiberisfurthercompactedthroughtheinteractionofalinkerhistone,H1,withtheDNAbetweenthenucleosomestoformhigherorderchromatinstructures.ThisgeneisintronlessandencodesamemberofthehistoneH2Bfamily.Transcriptsfromthisgenecontainapalindromicterminationelement.
        GeneSymbol
        • GL105
        • H2B
        • H2B-GL105
        • H2B.1
        • H2B.q
        • H2B/q
        • H2BFQ
        • MGC119802
        • MGC119804
        • MGC129733
        • MGC129734
        • OTTHUMP00000013920
        PurificationMethodProteinAchromatography
        UniProtNumber
        UniProtSummaryFUNCTION:SwissProt:Q8N257#Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstability.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.
        SIZE:126aminoacids;13908Da
        SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA.
        SUBCELLULARLOCATION:Nucleus.
        PTM:MonoubiquitinationofLys-121bytheRNF20/40complexgivesaspecifictagforepigenetictranscriptionalactivationandisalsoprerequisiteforhistoneH3"Lys-4"and"Lys-79"methylation.ItalsofunctionscooperativelywiththeFACTdimertostimulateelongationbyRNApolymeraseII.&PhosphorylatedonSer-15bySTK4/MST1duringapoptosis;whichfacilitatesapoptoticchromatincondensation.AlsophosphorylatedonSer-15inresponsetoDNAdoublestrandbreaks(DSBs),andincorrelationwithsomatichypermutationandimmunoglobulinclass-switchrecombination.
        SIMILARITY:SwissProt:Q8N257##BelongstothehistoneH2Bfamily.
        MolecularWeight~17kDaobserved;13.91kDacalculated.Uncharacterizedbandsmaybeobservedinsomelysate(s).
        PhysicochemicalInformation
        Dimensions
        MaterialsInformation
        MaterialsInformation
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