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    當前位置 ： Millipore >>> Millipore/07-218 | Anti-Notch1 Antibody, extracellular domain/07-218/100 µg
    Millipore/07-218 | Anti-Notch1 Antibody, extracellular domain/07-218/100 µg
    • Millipore/07-218 | Anti-Notch1 Antibody, extracellular domain/07-218/100 µg

    Millipore/07-218 | Anti-Notch1 Antibody, extracellular domain/07-218/100 µg

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    貨號: 07-218
    品牌: Millipore
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      • Description
        CatalogueNumber07-218
        Replaces04-1046
        BrandFamilyUpstate
        TradeName
        • Upstate
        DescriptionAnti-Notch1Antibody,extracellulardomain
        BackgroundInformationTheNotchproteinfamilyisagroupofhighlyconservedproteinsimportantinthedeterminationofcellfateandmaintenanceofProgenitorsinmanydevelopmentalsystems.Thisfamilyofproteinsfunctionbothasmembranecellreceptorsandastranscriptionfactors.ActivationofNotchbycell-cellinteractionscausesatranscriptioninhibitoryeffectthatenablesinhibitionofdifferentiationinsomecellsbutnotinothers.Asaconsequence,somecellsadoptaparticularfatewhileotherprogenitorsremainuncommitted.TheNotchproteinisimportantincellfateduringmyogenesis,neurogenesis,oogenesis,andwingandeyedevelopmentinDrosophila.Inmammals,fourNotchgeneswereidentified(Notch1-4)thatareexpressedinawidevarietyofcellsandplayacrucialroleindifferentiationanddevelopment.
        ProductInformation
        FormatPurified
        Control
        • L/N17transfectedNotch1celllysate
        PresentationProteinApurifiedimmunoglobulinpresentedin0.1MTris-Glycine,0.15MNaCl,and0.05%SodiumAzide,pH7.4
        StorageandShippingInformation
        StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
        Applications
        ApplicationAnti-Notch1Antibody,extracellulardomainisahighqualityRabbitPolyclonalAntibodyforthedetectionofNotch1&hasbeenvalidatedinWB.
        KeyApplications
        • WesternBlotting
        BIOLOGicalInformation
        ImmunogenN-terminalGSTfusionproteincorrespondingtoresidues381-853ofratNotch1
        HostRabbit
        SpecificityNotch1
        IsotypeIgG
        SpeciesReactivity
        • Rat
        • Mouse
        SpeciesReactivityNoteUsedinmouseinthefollowingpublication:Gulino,R.,etal,EuropeanJournalofNeuroscience,Vol.31,pp.1423–1434,2010.
        AntibodyTypePolyclonalAntibody
        EntrezGeneNumber
        EntrezGeneSummaryThisgeneencodesamemberoftheNotchfamily.MembersofthisType1transmembraneproteinfamilysharestructuralcharacteristicsincludinganextracellulardomainconsistingofmultipleepidermalgrowthfactor-like(EGF)repeats,andanintracellulardomainconsistingofmultiple,differentdomaintypes.Notchfamilymembersplayaroleinavarietyofdevelopmentalprocessesbycontrollingcellfatedecisions.TheNotchsignalingnetworkisanevolutionarilyconservedintercellularsignalingpathwaywhichregulatesinteractionsbetweenphysicallyadjacentcells.InDrosophilia,notchinteractionwithitscell-boundligands(delta,serrate)establishesanintercellularsignalingpathwaythatplaysakeyroleindevelopment.Homologuesofthenotch-ligandshavealsobeenidentifiedinhuman,butpreciseinteractionsbetweentheseligandsandthehumannotchhomologuesremaintobedetermined.Thisproteiniscleavedinthetrans-Golginetwork,andpresentedonthecellsurfaceasaheterodimer.Thisproteinfunctionsasareceptorformembraneboundligands,andmayplaymultiplerolesduringdevelopment.
        GeneSymbol
        • NOTCH1
        • notch1
        • hN1
        • TAN1
        PurificationMethodProteinAchromatography
        UniProtNumber
        UniProtSummaryFUNCTION:SwissProt:P46531#Functionsasareceptorformembrane-boundligandsJagged1,Jagged2andDelta1toregulatecell-fatedetermination.Uponligandactivationthroughthereleasednotchintracellulardomain(NICD)itformsatranscriptionalactivatorcomplexwithRBP-Jkappaandactivatesgenesoftheenhancerofsplitlocus.Affectstheimplementationofdifferentiation,proliferationandapoptoticprograms.Maybeimportantfornormallymphocytefunction.Inalteredform,maycontributetotransformationorprogressioninsomeT-cellneoplasms.InvolvedinthematurationofbothCD4+andCD8+cellsinthethymus.MaybeimportantforfolliculardifferentiationandpossIBLycellfateselectionwithinthefollicle.Duringcerebellardevelopment,mayfunctionasareceptorforneuronalDNERandmaybeinvolvedinthedifferentiationofBergmannglia(Bysimilarity).
        SIZE:2556aminoacids;272500Da
        SUBUNIT:HeterodimerofaC-terminalfragmentN(TM)andanN-terminalfragmentN(EC)whichareprobablylinkedbydisulfidebonds.InteractswithDNER,DTX1,DTX2andRBPSUH.AlsointeractswithMAML1,MAML2andMAML3whichactastranscriptionalcoactivatorsforNOTCH1.
        SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein(Bysimilarity).&Notch1intracellulardomain:Nucleus(Bysimilarity).Note=FollowingproteolyticalprocessingNICDistranslocatedtothenucleus(Bysimilarity).
        TISSUESPECIFICITY:Infetaltissuesmostabundantinspleen,brainstemandlung.Alsopresentinmostadulttissueswhereitisfoundmainlyinlymphoidtissues.
        PTM:Synthesizedintheendoplasmicreticulumasaninactiveformwhichisproteolyticallycleavedbyafurin-likeconvertaseinthetrans-Golginetworkbeforeitreachestheplasmamembranetoyieldanactive,ligand-accessibleform.CleavageresultsinaC-terminalfragmentN(TM)andaN-terminalfragmentN(EC).Followingligandbinding,itiscleavedbyTNF-alphaconvertingenzyme(TACE)toyieldamembrane-associatedintermediatefragmentcallednotchextracellulartruncation(NEXT).Thisfragmentisthencleavedbypresenilindependentgamma-secretasetoreleaseanotch-derivedpeptidecontainingtheintracellulardomain(NICD)fromthemembrane(Bysimilarity).&Phosphorylated(Bysimilarity).
        DISEASE:SwissProt:P46531#NOTCH1truncationisassociatedwithT-cellacutelymphoblasticleukemia.&DefectsinNOTCH1areacauseofaorticvalvedisease[MIM:109730].Thedisorderconsistsofanearlydevelopmentaldefectintheaorticvalveandalaterde-repressionofcalciumdepositionthatcausesprogressiveaorticvalvedisease.CalcificationoftheaorticvalveisthethirdleADIngcauseofheartdiseaseinadults.Theincidenceincreaseswithage,anditisoftenassociatedwithabicUSPidaorticvalvepresentin1-2%ofthepopulation.
        SIMILARITY:SwissProt:P46531##BelongstotheNOTCHfamily.&Contains5ANKrepeats.&Contains36EGF-likedomains.&Contains3LNR(Lin/Notch)repeats.
        MolecularWeight260kDa
        PhysicochemicalInformation
        Dimensions
        MaterialsInformation
        MaterialsInformation
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