| Immunogen | TheimmunogenwasapeptidecorrespondingtheC-terminalregionofhumanSIRT3. |
| Epitope | C-terminus |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | ThisantibodyrecognizesSIRT3.Endogenouslevelsofthisproteinvaryamongcelllines;theproteinwaseasilydetectedinRAW264.7andC2C12cellsbutonlyweaklydetectedinHeLacells,andnotdetectedinJurkat,HEK293orPC3cells. |
| SpeciesReactivity | |
| SpeciesReactivityNote | Human,Mouse.Nottestedinotherspecies. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesamemberofthesirtuinfamilyofproteins,homologstotheyeastSir2protein.Membersofthesirtuinfamilyarecharacterizedbyasirtuincoredomainandgroupedintofourclasses.Thefunctionsofhumansirtuinshavenotyetbeendetermined;however,yeastsirtuinproteinsareknowntoregulateepigeneticgenesilencingandsuppressrecombinationofrDNA.Studiessuggestthatthehumansirtuinsmayfunctionasintracellularregulatoryproteinswithmono-ADP-ribosyltransferaseactivity.TheproteinencodedbythisgeneisincludedinclassIofthesirtuinfamily.Twoalternativelysplicedtranscriptvariantsthatencodedifferentproteinshavebeendescribedforthisgene.[providedbyRefSeq].
|
| GeneSymbol | |
| PurificationMethod | Purified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:NAD-dependentdeacetylase.DespitesomeABIlitytodeacetylatehistonesinvitro,itisunlikelyinvivo.
CatalyticactivityNAD++anacetylprotein=nicotinamide+O-acetyl-ADP-ribose+aprotein.Ref.4Ref.5
CofactorBinds1zincionpersubunitBysimilarity.
SUBCELLULARLOCATION:Mitochondrionmatrix.Ref.4Ref.5
TISSUESPECIFICITY:Widelyexpressed.Ref.5Ref.1
PTM:Processedbymitochondrialprocessingpeptidase(MPP)togivea28kDaproduct.Suchprocessingisprobablyessentialforitsenzymaticactivity.
SEQUENCESIMILARITY:Belongstothesirtuinfamily.
Contains1deacetylasesirtuin-typedomain.
|
| MolecularWeight | 44kDa |