| Immunogen | SyntheticpeptidecorrespondingaminoacidswiththeC-terminusofhumanGLUT-1coupledtoKLH(C-ELFHPLGADSQV). |
| Epitope | C-Terminus |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | ThisrabbitpolyclonalantibodydetectsGLUT-1inhumanandmousecells.Ittargetsanepitopewithin12aminoacidsfromtheC-terminalhalf.
|
| Isotype | IgG |
| SpeciesReactivity | |
| SpeciesReactivityNote | Human.Mouse.PredictedtoreactwithRatbasedon100%sequencehomology.
|
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesamajorglucosetransporterinthemammalianblood-brainbarrier.Mutationsinthisgenehavebeenfoundinafamilywithparoxysmalexertion-induceddyskinesia.[providedbyRefSeq].
|
| GeneSymbol | - GLUT
- GLUT-1
- GLUT1
- MGC141895
- MGC141896
|
| PurificationMethod | AffinityPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:Facilitativeglucosetransporter.Thisisoformmayberesponsibleforconstitutiveorbasalglucoseuptake.Hasaverybroadsubstratespecificity;cantransportawiderangeofaldosesincludingbothpentosesandhexoses. SUBCELLULARLOCATION:Cellmembrane;Multi-passmembraneprotein(Bysimilarity).Melanosome.Note=Localizesprimarilyatthecellsurface(Bysimilarity).IdentifiedbymassspectrometryinmelanosomefractionsfromstageItostageIV. TISSUESPECIFICITY:Expressedatvariablelevelsinmanyhumantissues. PTM:PhosphorylateduponDNAdamage,probablybyATMorATR. DISEASE:DefectsinSLC2A1arethecauseofautosomaldominantGLUT1deficiencysyndrome[MIM:606777].Thisdiseasecausesadefectinglucosetransportacrosstheblood-brainbarrier.Itischaracterizedbyinfantileseizures,delayeddevelopment,andacquiredmicrocephaly. SIMILARITY:Belongstothemajorfacilitatorsuperfamily.Sugartransporter(TC2.A.1.1)family.Glucosetransportersubfamily[viewclassification].
|
| MolecularWeight | Thisantibodydetectsamajorband~54kDainWesternblotanalysis. |