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    當前位置 ： Millipore >>> Millipore/07-131 | Anti-Sirt1(Sir2) Antibody/07-131/200 µL
    Millipore/07-131 | Anti-Sirt1(Sir2) Antibody/07-131/200 µL
    • Millipore/07-131 | Anti-Sirt1(Sir2) Antibody/07-131/200 µL

    Millipore/07-131 | Anti-Sirt1(Sir2) Antibody/07-131/200 µL

    價格: ￥5052.00 市場價: 8420.00
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    貨號: 07-131
    品牌: Millipore
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      • Description
        CatalogueNumber07-131
        Replaces05-707
        BrandFamilyUpstate
        TradeName
        • Upstate
        DescriptionAnti-Sirt1(Sir2)Antibody
        AlternateNames
        • SIR2-likeprotein2
        • silencinginformationregulator2-like
        • silentinformationregulator2
        • sir2-relatedproteintype2
        • sirtuin(silentmatingtypeinformationregulation2homolog)2(S.cerevisiae)
        • sirtuin(silentmatingtypeinformationregulation2,S.cerevisiae
        • homolog)2
        • sirtuin2
        • sirtuintype2
        BackgroundInformationSirtuinsareafamilyofcloselyrelatedenzymesnamedaftertheyeastgeneSir2(silentmatingtypeinformationregulation2).MembersoftheSirtuinfamilyhavebeenfoundinnearlyallorganismsstudied.Sirtuinsarehypothesizedtoplayakeyroleinanorganism"sresponsetostresses(suchasheatorstarvation)andtoberesponsIBLefortheLifespan-extendingeffectsofcalorierestriction.SirtuinsactbyremovingacetylgroupsfromproteinsinthepresenceofNAD+;theyarethusclassifiedas"NAD+-dependentdeacetylases".Sirtuinshavebeenimplicatedintheregulationofaging,transcription,apoptosisandstressresistance.Sirt1(alsoknownasSirtuin1,Sir2L1,andSir2a),themammalianhomologofyeastSir2,hasbeenshowntodeacetylateandtherebydeactivatethep53proteintoregulatecellularprocesses.
        ProductInformation
        FormatAffinityPurified
        Control
        • Jurkatcelllysate,humancoloncarcinomaorhumanlungsquamouscarcinoma.
        PresentationPurifiedrabbitIgGinbuffercontaining0.1MTris-Glycine,0.15MNaCl,0.05%sodiumazideand30%gylcerol
        StorageandShippingInformation
        StorageConditions1yearat-20°Cfromdateofshipment.
        HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.
        Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
        Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.
        Applications
        ApplicationUseAnti-Sirt1(Sir2)Antibody(RabbitPolyclonalAntibody)ispublished(morethan30citations)andvalidatedinICC,IP,WBtodetectSirt1(Sir2)alsoknownasSilencinginformationregulator2-like,sirtuin2.
        KeyApplications
        • Immunocytochemistry
        • Immunoprecipitation
        • WesternBlotting
        • ChromatinImmunoprecipitation(ChIP)
        ApplicationNotesImmunoprecipitation:
        5μLofapreviouslotofthisantibodyhasbeenshowntoimmunoprecipitateSirt1from1mgofa3T3/A31RIPAcellextract.

        Immunocytochemistry:
        ThisantibodyhasbeenreportedtodetectSirt1in3T3cellsfixedwithparaformaldehyde.

        ChromatinImmunoprecipitation:
        PublishedbyTiberietal.,(2012)
        BIOLOGicalInformation
        ImmunogenGST-taggedfusionproteincorrespondingtoaminoacids1-131ofmouseSir2α.
        Epitopea.a.1-131
        ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
        HostRabbit
        SpecificityThisantibodyrecognizesSirt1.
        IsotypeIgG
        SpeciesReactivity
        • Mouse
        • Human
        AntibodyTypePolyclonalAntibody
        EntrezGeneNumber
        EntrezGeneSummaryThisgeneencodesamemberofthesirtuinfamilyofproteins,homologstotheyeastSir2protein.Membersofthesirtuinfamilyarecharacterizedbyasirtuincoredomainandgroupedintofourclasses.Thefunctionsofhumansirtuinshavenotyetbeendetermined;however,yeastsirtuinproteinsareknowntoregulateepigeneticgenesilencingandsuppressrecombinationofrDNA.Studiessuggestthatthehumansirtuinsmayfunctionasintracellularregulatoryproteinswithmono-ADP-ribosyltransferaseactivity.TheproteinencodedbythisgeneisincludedinclassIofthesirtuinfamily.Twotranscriptvariantsresultfromalternativesplicingofthisgene.
        GeneSymbol
        • SIR2L1
        • SIR2alpha
        • hSIR2
        • hSIRT1
        PurificationMethodImmunoaffinityChromatography
        UniProtNumber
        UniProtSummaryFUNCTION:NAD-dependentdeacetylase,whichregulatesprocessessuchasapoptosisandmuscledifferentiationbydeacetylatingkeyproteins.Essentialduringembryogenesisandgametogenesis.Deacetylates"Lys-382"ofp53/TP53andimpairsitsabilitytoinduceproapoptoticprogramandmodulatecellsenescence.DeacetylatesTAF1BandtherebyrepressesrDNAtranscriptionbytheRNApolymeraseI.InvolvedinHES1-andHEY2-mediatedtranscriptionalrepression.InhibitsskeletalmuscledifferentiationbydeacetylatingPCAFandMYOD1.MayserveasasensorofthecytosolicratioofNAD(+)/NADH,whichisessentialinskeletalmusclecelldifferentiation.Despitesomeabilitytodeacetylatehistonesinvitro,suchactivityiseitherweakorinexistentinvivo.
        CATALYTICACTIVITY:NAD++anacetylprotein=nicotinamide+O-acetyl-ADP-ribose+aprotein.
        COFACTOR:Binds1zincionpersubunit(Bysimilarity).
        ENZYMEREGULATION:Activatedbyresveratrol(3,5,4"-trihydroxy-trans-stilbene),butein(3,4,2",4"-tetrahydroxychalcone),piceatannol(3,5,3",4"-tetrahydroxy-trans-stilbene),Isoliquiritigenin(4,2",4"-trihydroxychalcone),fisetin(3,7,3",4"-tetrahydroxyflavone)andquercetin(3,5,7,3",4"-pentahydroxyflavone)(Bysimilarity).Inhibitedbynicotinamide.
        SUBUNIT:InteractswithMLLT7/FOXO4,HES1,HEY2andPML(Bysimilarity).FoundinacomplexwithPCAFandMYOD1.Interactswithp53/TP53.InteractswithTAF1B.
        SUBCELLULARLOCATION:Nucleus(Bysimilarity).Note=RecruitedtothenuclearbodiesviaitsinteractionwithPML(Bysimilarity).
        TISSUESPECIFICITY:Widelyexpressed.Weaklyexpressedinliverandskeletalmuscle.
        SIMILARITY:Belongstothesirtuinfamily.
        SIMILARITY:Contains1deacetylasesirtuin-typedomain.
        MolecularWeight110kDa;Uncharacterizedbands70and50observedinsomeLysates.
        PhysicochemicalInformation
        Dimensions
        MaterialsInformation
        MaterialsInformation
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