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    當前位置 ： Millipore >>> Millipore/07-1232 | Anti-Notch 1 Antibody, NT/07-1232/200 µL
    Millipore/07-1232 | Anti-Notch 1 Antibody, NT/07-1232/200 µL
    • Millipore/07-1232 | Anti-Notch 1 Antibody, NT/07-1232/200 µL

    Millipore/07-1232 | Anti-Notch 1 Antibody, NT/07-1232/200 µL

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    貨號: 07-1232
    品牌: Millipore
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      • Description
        CatalogueNumber07-1232
        Replaces04-1046
        DescriptionAnti-Notch1Antibody,NT
        AlternateNames
        • Neurogeniclocusnotchhomologprotein1precursor
        • Notch(Drosophila)homolog1(translocation-associated)
        • Notch1
        • Notchhomolog1,translocation-associated(Drosophila)
        • Translocation-associatednotchproteinTAN-1
        • Neurogeniclocusnotchhomologprotein1
        BackgroundInformationNotchisafamilyofsingle-passtransmembranereceptorproteinsthataresynthesizedintheendoplasmicreticulumasaninactiveformandareproteolyticallycleavedonanextracellularsitebyafurin-likeconvertase(S1cleavage)inthetrans-golginetworkaftertherecognitionoftheRQRRsequencebeforeitreachestheplasmamembraneasheterodimerstoyieldanactive,ligand-accessIBLeform.TheNotchfamilyiscomprisedof4members(1-4)whoseligandsincludetheDeltaandJaggedfamilyofligands.TheseligandscauseproteolysisofNotchtoliberatetheintracellulardomain.CleavageresultsinaC-terminalfragmentN(TN)andaN-terminalfragmentN(EC).Followingligandbinding,itiscleaved(S2cleavage)byTNF-alphaconvertingenzyme(TACE)toyieldamembrane-associatedintermediatefragmentcalledNotchextracellulartruncation(NEXT).Thisfragmentisthencleavedbypresenilin-dependentgamma-secretasebetweengly1743andval1744(S3cleavage)toreleasetheintracellulardomain(NICD)fromthemembrane.ThatdomaintranslocatestothenucleusandinitiatestranscriptioneventsbybindingtheDNAbindingproteinCSL.Thenotchfamilymembersareinvolvedcelldifferentiationanddevelopment.
        ProductInformation
        FormatSerum
        Control
        • JurkateCellLysates.Infetaltissues,usespleen,brainstemandlung.Inadulttissuesusemainlylymphoidtissues.
        PresentationRabbitpolyclonalIgGseruminbuffercontaining0.02MPotassiumPhosphate,0.15MNaCl,pH7.2,containing0.1%sodiumazide.
        StorageandShippingInformation
        StorageConditionsStablefor6monthsat-20°Cinundilutedaliquotsfromdateofreceipt.Avoidrepeatedfreeze/thawcycles.
        HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
        Applications
        ApplicationAnti-Notch1Antibody,N-TerminusisaRabbitPolyclonalAntibodyfordetectionofNotch1alsoknownasNeurogeniclocusnotchhomologprotein1precursor&hasbeenvalidatedinELISA,WB,IHC(P).
        KeyApplications
        • ELISA
        • WesternBlotting
        • Immunohistochemistry(Paraffin)
        ApplicationNotesELISA:
        Apreviouslotofthisantibodywasdilutedto1:20,000-1:60,000andusedinastandardsandwichELISAassayagainstthepeptideimmunogen.

        Immunohistochemistry(paraffin):
        Representativetestingfromapreviouslot.
        OptimalStainingofNotch-1WithCitratepH6.0EpitopeRetrieval:UterineCancer

        ELISA:Apreviouslotofthisantibodywasdilutedto1:20,000-1:60,000andusedinastandardsandwichELISAassayagainstthepeptideimmunogen.
        BIOLOGicalInformation
        ImmunogenSyntheticpeptidefromtheN-terminalsequenceofthecleavedNintracellulardomain(NICD)humanNotch1.
        EpitopeCleavedN-Terminus
        HostRabbit
        SpecificityNotch1,cleavedNterminal.Onlythecleavedintracellular(activated)formisdetected.NoreactivityisdetectedagainstmouseN2,N3orN4.Thisepitopeisexposedonlyaftergammasecretasecleavageandisnotaccessibleintheuncleavedform.
        IsotypeIgG
        SpeciesReactivity
        • Human
        • Mouse
        SpeciesReactivityNoteHumanandmouse.Theantibodyisalsoexpectedtoreactwithratduetoimmunogensequencehomology.Otherspecieshavenotbeentested.
        AntibodyTypePolyclonalAntibody
        EntrezGeneNumber
        EntrezGeneSummaryThisgeneencodesamemberoftheNotchfamily.MembersofthisType1transmembraneproteinfamilysharestructuralcharacteristicsincludinganextracellulardomainconsistingofmultipleepidermalgrowthfactor-like(EGF)repeats,andanintracellulardomainconsistingofmultiple,differentdomaintypes.Notchfamilymembersplayaroleinavarietyofdevelopmentalprocessesbycontrollingcellfatedecisions.TheNotchsignalingnetworkisanevolutionarilyconservedintercellularsignalingpathwaywhichregulatesinteractionsbetweenphysicallyadjacentcells.InDrosophilia,notchinteractionwithitscell-boundligands(delta,serrate)establishesanintercellularsignalingpathwaythatplaysakeyroleindevelopment.Homologuesofthenotch-ligandshavealsobeenidentifiedinhuman,butpreciseinteractionsbetweentheseligandsandthehumannotchhomologuesremaintobedetermined.Thisproteiniscleavedinthetrans-Golginetwork,andpresentedonthecellsurfaceasaheterodimer.Thisproteinfunctionsasareceptorformembraneboundligands,andmayplaymultiplerolesduringdevelopment.
        GeneSymbol
        • NOTCH1
        • notch1
        • hN1
        • TAN1
        UniProtNumber
        UniProtSummaryFUNCTION:SwissProt:P46531#Functionsasareceptorformembrane-boundligandsJagged1,Jagged2andDelta1toregulatecell-fatedetermination.Uponligandactivationthroughthereleasednotchintracellulardomain(NICD)itformsatranscriptionalactivatorcomplexwithRBP-Jkappaandactivatesgenesoftheenhancerofsplitlocus.Affectstheimplementationofdifferentiation,proliferationandapoptoticprograms.Maybeimportantfornormallymphocytefunction.Inalteredform,maycontributetotransformationorprogressioninsomeT-cellneoplasms.InvolvedinthematurationofbothCD4+andCD8+cellsinthethymus.Maybeimportantforfolliculardifferentiationandpossiblycellfateselectionwithinthefollicle.Duringcerebellardevelopment,mayfunctionasareceptorforneuronalDNERandmaybeinvolvedinthedifferentiationofBergmannglia(Bysimilarity).
        SIZE:2556aminoacids;272500Da
        MolecularWeight~80kDa
        PhysicochemicalInformation
        Dimensions
        MaterialsInformation
        MaterialsInformation
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