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    當前位置 ： Millipore >>> Millipore/06-734 | Anti-β-Catenin Antibody/06-734/200 µg
    Millipore/06-734 | Anti-β-Catenin Antibody/06-734/200 µg
    • Millipore/06-734 | Anti-β-Catenin Antibody/06-734/200 µg

    Millipore/06-734 | Anti-β-Catenin Antibody/06-734/200 µg

    價格: ￥4440.00 市場價: 7400.00
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    貨號: 06-734
    品牌: Millipore
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      • Description
        CatalogueNumber06-734
        BrandFamilyUpstate
        TradeName
        • Upstate
        DescriptionAnti-β-CateninAntibody
        AlternateNames
        • catenin(cadherin-associatedprotein)
        • beta1(88kD)
        • catenin(cadherin-associatedprotein),beta1(88kDa)
        • catenin(cadherin-associatedprotein),beta1,88kDa
        BackgroundInformationβ-cateninplaysacentralroleincelladhesion,bridgingbetweencadherinsandactinCytoskeleton.Theseactivitiesareregulatedthroughitsdifferentialinteractionwithseveralmolecularpartners,includingcell-celladherensjunction(AJ)molecules,componentsofitsdegradationcomplex,andtranscriptionfactors.
        β-Cateniniscomposedofthreedomains:acentralarmADIllorepeatdomainandtwoN-andC-terminaltails.β-catenincanbephosphorylatedbyserine-threoninekinase,suchasGSK-3.Thephosphorylatedβ-cateninaffectstheproteinassociationofβ-catenintoE-cadherinandα-cateininthatoccursinthecell.Thisprocesscanbereversedbyde-phosphorylationofβ-catenin.
        ProductInformation
        FormatPurified
        Control
        • A431celllysate
          IncludedPositiveAntigenControl:Catalog#12-301,NonstimulatedA431celllysate.Add2.5μLof2-mercaptoethanol/100μLoflysateandboilfor5minutestoreducethepreparation.Load20μgofreducedlysateperlaneforminigels.
        PresentationPurifiedrabbitpolyclonalIgGinbuffercontaining0.1MTrisGlycine,0.15MNaCl,0.05%SodiumAzide,pH7.4.
        StorageandShippingInformation
        StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
        HandlingRecommendations:Priortoremovingthecap,centrifugethevialandgentlymixthesolution.
        Applications
        ApplicationUseAnti-β-CateninAntibody(RabbitPolyclonalAntibody)validatedinICC,IP,WBtodetectβ-Cateninalsoknownascatenin(cadherin-associatedprotein)beta1(88kD).
        KeyApplications
        • Immunocytochemistry
        • Immunoprecipitation
        • WesternBlotting
        ApplicationNotesImmunoprecipitation:
        5μgofapreviouslotimmunoprecipitatedβ-Cateninfrom500μgofA431membranefractionlysate.

        Immunocytochemistry:
        1-5μg/mLofapreviouslotshowedpositiveimmunostainingforβ-cateninatcell-celljunctionsofA431cellsfixedwith4%paraformaldehydeandpermeABIlizedwith0.25%Triton?X-100.
        BIOLOGicalInformation
        ImmunogenKLH-conjugated,syntheticpeptide(CGG-SYLDSGIHSGATTTAPSLSGK)correspondingtotheconsensusGSK3phosphorylationsiteofhumanβ-Catenin(aminoacids29-49).
        ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
        HostRabbit
        SpecificityRecognizesβ-Catenin,Mr92kDa.
        IsotypeIgG
        SpeciesReactivity
        • Human
        • Rat
        • Mouse
        • Rabbit
        • Bovine
        AntibodyTypePolyclonalAntibody
        EntrezGeneNumber
        EntrezGeneSummaryBeta-cateninisanadherensjunctionprotein.Adherensjunctions(AJs;alsocalledthezonulaadherens)arecriticalfortheestablishmentandmaintenanceofepitheliallayers,suchasthoseliningorgansurfaces.AJsmediateadhesionbetweencells,communicateasignalthatneighboringcellsarepresent,andanchortheactincytoskeleton.Inservingtheseroles,AJsregulatenormalcellgrowthandbehavior.Atseveralstagesofembryogenesis,woundhealing,andtumorcellmetastasis,cellsformandleaveepithelia.Thisprocess,whichinvolvesthedisruptionandreestablishmentofepithelialcell-cellcontacts,mayberegulatedbythedisassemblyandassemblyofAJs.AJsmayalsofunctioninthetransmissionofthe"contactinhibition"signal,whichinstructscellstostopdividingonceanepithelialsheetiscomplete.[suppliedbyOMIM]
        GeneSymbol
        • CTNNB1
        • CTNNB
        • Beta-catenin
        • PRO2286
        • FLJ37923
        • FLJ25606
        • DKFZp686D02253
        PurificationMethodProteinAchromatography
        UniProtNumber
        UniProtSummaryFUNCTION:SwissProt:P35222#InvolvedintheregulationofcelladhesionandinsignaltransductionthroughtheWntpathway.
        SIZE:781aminoacids;85497Da
        SUBUNIT:Twoseparatepoolsarefoundinthecytoplasm:oneisPSEN1/cadherin/catenincomplexwhichanchorstotheactincytoskeleton.TheotherpoolispartofalargecomplexcontainingAXIN1,AXIN2,APC,CSNK1A1andGSK3BthatpromotesphosphorylationonN-terminalSerandThrresiduesandubiquitinationofCTNNB1viaBTRCanditssubsequentdegradationbytheproteasome.Wnt-dependentactivationofDVLantagonizestheactionofGSK3B.WhenGSK3Bactivityisinhibitedthecomplexdissociates,CTNNB1isdephosphorylatedandisnolongertargetedfordestruction.Thestabilizedproteintranslocatestothenucleus,whereitbindsTCF/LEF-1familymembers,TBP,BCL9andpossIBLyalsoRUVBL1andDUPLIN.BindsCTNNBIPandEP300.CTNNB1formsaternarycomplexwithLEF1andEP300thatisdisruptedbyCTNNBIP1binding(Bysimilarity).InteractswiththePDZdomainofTAX1BP3;thisinteractioninhibitsthetranscriptionalactivityofCTNNB1(Bysimilarity).InteractswithAJAP1,BAIAP1,CARM1,CTNNA3,CXADRandPCDH11Y.BindsSLC9A3R1.InteractswithGLIS2.InteractswithSLC30A9(Bysimilarity).
        SUBCELLULARLOCATION:Cytoplasm.Nucleus.Note=Cytoplasmicwhenitisunstabilized(highlevelofphosphorylation)orboundtoCDH1.Translocatestothenucleuswhenitisstabilized(lowlevelofphosphorylation).InteractionwithGLIS2promotesnucleartranslocation.
        TISSUESPECIFICITY:Expressedinseveralhairfolliclecelltypes:basalandperipheralmatrixcells,andcellsoftheouterandinnerrootsheats.Expressedincolon.
        PTM:PhosphorylationbyGSK3BrequirespriorphosphorylationofSer-45byanotherkinase.PhosphorylationproceedsthenfromThr-41toSer-37andSer-33.&EGFstimulatestyrosinephosphorylation.PhosphorylationonTyr-654decreasesCDH1bindingandenhancesTBPbinding.&UbiquitinatedbyaE3ubiquitinligasecomplexcontainingUBE2D1,SIAH1,CACYBP/SIP,SKP1A,APCandTBL1X(Probable).Itsubiquitinationleadstoitssubsequentproteasomaldegradation.
        DISEASE:"SwissProt:P35222#ActivatingmutationsinCTNNB1haveoncogenicactivityresultingintumordevelopment.Somaticmutationsarefoundinvarioustumortypes,includingcoloncancers,ovarianandprostatecarcinomas,hepatoblastoma(HB),hepatocellularcarcinoma(HCC).HBsaremalignantembryonaltumorsmainlyaffectingyoungchildreninthefirstthreeyearsoflife.&DefectsinCTNNB1areacauseofpilomatrixoma(PTR)[MIM:132600];acommonbenignskintumor.&DefectsinCTNNB1areacauseofmedulloblastoma(MDB)[MIM:155255].MDBisamalignant,invasiveembryonaltumorofthecerebellumwithapreferentialmanifestationinchildren.&AchromosomalrearrangementinvolvingCTNNB1maybeacauseofsalivaryglandpleiomorphicadenomas(PA)[181030].Pleiomorphicadenomasarethemostcommonbenignepithelialtumorsofthesalivarygland.Translocationt(3;8)(p21;q12)withPLAG1."
        SIMILARITY:SwissProt:P35222##Belongstothebeta-cateninfamily.&Contains12ARMrepeats.
        MolecularWeight92kDa
        PhysicochemicalInformation
        Dimensions
        MaterialsInformation
        MaterialsInformation
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