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    當前位置 ： Millipore >>> Millipore/06-574 | Anti-TrkA Antibody/06-574/200 µg
    Millipore/06-574 | Anti-TrkA Antibody/06-574/200 µg
    • Millipore/06-574 | Anti-TrkA Antibody/06-574/200 µg

    Millipore/06-574 | Anti-TrkA Antibody/06-574/200 µg

    價格: ￥5052.00 市場價: 8420.00
    打印產品信息
    貨號: 06-574
    品牌: Millipore
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      • Description
        CatalogueNumber06-574
        ReplacesCBL770
        BrandFamilyUpstate
        TradeName
        • Upstate
        DescriptionAnti-TrkAAntibody
        AlternateNames
        • Neurotrophictyrosinekinasereceptortype
        • OncogeneTRK
        • TRK1-transformingtyrosinekinaseprotein
        • highaffinitynervegrowthfactorreceptor
        • neurotrophictyrosinekinase,receptor,type1
        • tyrosinekinasereceptorA
        BackgroundInformationTrkA,apparentmolecularweight140kDa,isahighaffinitynervegrowthfactor(NGF).TheTrkproto-oncogenefamilycontainsfourmembers,TrkA,TrkB,TrkC,andTrkE,whicharevariablyexpressedthroughoutthecentralandperipheralnervoussystems.TrkAbindstonervegrowthfactor(NGF)andautophosphorylatesontyrosineresidues(Tyr490,Tyr674,Tyr675,Tyr751andTyr785)toactivatemultipledownstreameffectorproteins.PhosphorylationatTyr490isrequiredforShcassociationandsubsequentactivationoftheRas-MAPkinase-signalingcascade,whichleadstoactivationofElk-1-dependentgenetranscriptionandneuritegrowth.PhosphorylationsatTyr674andTyr675liewithinthecatalyticdomainofTrkAtyrosinekinaseandreflectTrkkinaseactivity.Additionally,phosphorylationatTyr751isrequiredforPI3-kinaseassociationandactivationoftheAktsignalingcascade.
        ProductInformation
        FormatPurified
        Control
        • EGF-stimulatedA431cellysate,ratbraintissue.IncludedPositiveAntigenControl:Catalog#12-301,non-stimulatedA431celllysate.Add2.5μLof2-mercaptoethanol/100μLoflysateandboilfor5minutestoreducethepreparation.Load20μgofreducedlysateperlaneforminigels.
        PresentationPurifiedrabbitIgGinbuffercontaining0.02Mphosphatebuffer,pH7.6,0.25MNaCl,0.1%sodiumazide.Frozenat-20°C.
        StorageandShippingInformation
        StorageConditionsStablefor1yearat-20°Cfromdateofreceipt.
        HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.
        Applications
        ApplicationAnti-TrkAAntibodydetectslevelofTrkA&hasbeenpublished&validatedforuseinIC,IP&WB.
        KeyApplications
        • Immunocytochemistry
        • Immunoprecipitation
        • WesternBlotting
        ApplicationNotesImmunoprecipitation:
        4μgofapreviouslotimmunoprecipitatedTrkAfrom500μgofPC-12RIPAlysate.

        Immunocytochemistry:
        10μg/mLofapreviouslotofthisantibodyshowedpositiveimmunostainingforTrkAinPC-12cellsfixedwith4%paraformaldehyde.
        BIOLOGicalInformation
        ImmunogenRabbitsimmunizedwithbacteriallyexpressedpurifiedproteincorrespondingtotheentireextracellulardomainofratTrkAreceptor.
        ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
        HostRabbit
        SpecificityRecognizesTrkA,Mr140kDa.Doesnotcross-reactwithTrkBorTrkC.
        IsotypeIgG
        SpeciesReactivity
        • Human
        • Mouse
        • Rat
        SpeciesReactivityNoteRat,mouseandhuman.Reactivitywithotherspecieshasnotbeenconfirmed.
        AntibodyTypePolyclonalAntibody
        EntrezGeneNumber
        EntrezGeneSummaryThisgeneencodesamemberoftheneurotrophictyrosinekinasereceptor(NTKR)family.Thiskinaseisamembrane-boundreceptorthat,uponneurotrophinbinding,phosphorylatesitselfandmembersoftheMAPKpathway.Thepresenceofthiskinaseleadstocelldifferentiationandmayplayaroleinspecifyingsensoryneuronsubtypes.Mutationsinthisgenehavebeenassociatedwithcongenitalinsensitivitytopain,anhidrosis,self-mutilatingbehavior,mentalretardationandcancer.Alternatetranscriptionalsplicevariantsofthisgenehavebeenfound,butonlythreehavebeencharacterizedtodate.
        GeneSymbol
        • DKFZp781I14186
        • EC2.7.10.1
        • MTC
        • OTTHUMP00000038736
        • TRK
        • TRK1
        • TRKA
        • Trk-A
        • p140-TrkA
        PurificationMethodProteinAPurfied
        UniProtNumber
        UniProtSummaryFUNCTION:SwissProt:P04629#Requiredforhigh-affinitybindingtonervegrowthfactor(NGF),neurotrophin-3andneurotrophin-4/5butnotbrain-derivedneurotrophicfactor(BDNF).KnownsubstratesfortheTrkreceptorsareSHC1,PI3-kinase,andPLC-gamma-1.Hasacrucialroleinthedevelopmentandfunctionofthenociceptivereceptionsystemaswellasestablishmentofthermalregulationviasweating.ActivatesERK1byeitherSHC1-orPLC-gamma-1-dependentsignalingpathway.
        SIZE:796aminoacids;87497Da
        SUBUNIT:Existsinadynamicequilibriumbetweenmonomeric(lowaffinity)anddimeric(highaffinity)structures.BindsSH2B2.InteractswithSQSTM1whichbridgesNTRK1toNGFR(Bysimilarity).
        SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein(Bysimilarity).Note=EndocytosedtotheendosomesupontreatmentofcellswithNGF(Bysimilarity).
        TISSUESPECIFICITY:IsoformTrkA-IIisprimarilyexpressedinneuronalcells;isoformTrkA-Iisfoundinnon-neuronaltissues.
        PTM:Ligand-mediatedauto-phosphorylation.InteractionwithSQSTM1isphosphotyrosine-dependent.
        DISEASE:SwissProt:P04629#DefectsinNTRK1areacauseofcongenitalinsensitivitytopainwithanhidrosis(CIPA)[MIM:256800].CIPAischaracterizedbyacongenitalinsensitivitytopain,anhidrosis(absenceofsweating),absenceofreactiontonoxiousstimuli,self-mutilatingbehavior,andmentalretardation.ThisrareautosomalrecessivedisorderisalsoknownascongenitalsensoryneuropathywithanhidrosisorhereditarysensoryandautonomicneuropathytypeIVorfamilialdysautonomiatypeII.&ChromosomalaberrationsinvolvingNTRK1areacauseofthyroidpapillarycarcinoma(PACT)[MIM:188550].Translocationt(1;3)(q21;q11)withTFGgeneratestheTRKT3(TRK-T3)transcriptbyfusingTFGtothe3"-endofNTRK1;arearrangementwithTPM3generatestheTRKtranscriptbyfusingTPM3tothe3"-endofNTRK1.&ChromosomalaberrationsinvolvingNTRK1areacauseofthyroidpapillarycarcinoma(PACT)[MIM:188550].IntrachromosomalrearrangementthatlinkstheproteinkinasedomainofNTRK1tothe5"-endoftheTPRgeneformsthefusionproteinTRK-T1.TRK-T1isa55kDaproteinreactingwithantibodiesagainsttheC-terminusoftheNTRK1protein.
        SIMILARITY:SwissProt:P04629##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.Insulinreceptorsubfamily.&Contains2Ig-likeC2-type(immunoglobulin-like)domains.&Contains3LRR(leucine-rich)repeats.&Contains1proteinkinasedomain....hide?seemore?
        MolecularWeight140kDa
        PhysicochemicalInformation
        Dimensions
        MaterialsInformation
        MaterialsInformation
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