| Immunogen | Fusionproteinderivedthealpha3subunitcontainingresidues320-514 | 
| Host | Rabbit | 
| Specificity | Na+/K+ATPaseα-3 | 
| Isotype | IgG | 
| SpeciesReactivity |  | 
| AntibodyType | PolyclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | TheproteinencodedbythisgenebelongstothefamilyofP-typecationtransportATPases,andtothesubfamilyofNa+/K+-ATPases.Na+/K+-ATPaseisanintegralmembraneproteinresponsIBLeforestablishingandmaintainingtheelectRochemicalgrADIentsofNaandKionsacrosstheplasmamembrane.Thesegradientsareessentialforosmoregulation,forsodium-coupledtransportofavarietyoforganicandinorganicmolecules,andforelectricalexcitABIlityofnerveandmuscle.Thisenzymeiscomposedoftwosubunits,alargecatalyticsubunit(alpha)andasmallerglycoproteinsubunit(beta).ThecatalyticsubunitofNa+/K+-ATPaseisencodedbymultiplegenes.Thisgeneencodesanalpha3subunit. | 
| GeneSymbol | - ATP1A3
 - MGC13276
 - RDP
 - IIIsubunit).
 - DYT12
 - +K
 - Na
 
  | 
| PurificationMethod | ProteinAchromatography | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P13637#Thisisthecatalyticcomponentoftheactiveenzyme,whichcatalyzesthehydrolysisofATPcoupledwiththeexchangeofsodiumandpotassiumionsacrosstheplasmamembrane.Thisactioncreatestheelectrochemicalgradientofsodiumandpotassiumions,providingtheenergyforactivetransportofvariousnutrients. SIZE:1013aminoacids;111749Da SUBUNIT:Composedofthreesubunits:alpha(catalytic),betaandgamma. SUBCELLULARLOCATION:Membrane;Multi-passmembraneprotein. DISEASE:SwissProt:P13637#DefectsinATP1A3arethecauseofdystonia-12(DYT12)[MIM:128235];alsoknownasrapid-onsetdystoniaparkinsonism(RDP).DYT12isanautosomaldominantformofdystonia-parkinsonismcharacterizedbyanunusuallyrapidevolutionofsignsandsymptoms.Affectedpersonsdevelopdystoniaandparkinsonismbetween14and45yearsofage.Thesuddenonsetofsymptomsoverhourstoafewweeks,oftenassociatedwithphysicaloremotionalstress,suggestsatriggerinitiatinganervoussysteminsultresultinginpermanentneurologicdisability. SIMILARITY:SwissProt:P13637##BelongstothecationtransportATPase(P-type)family.TypeIICsubfamily. | 
| MolecularWeight | 112kDa |