| Immunogen | RecombinantextracellulardomainofmouseM-Cadherin |
| Clone | clone12G4 |
| Host | Mouse |
| Specificity | M-Cadherin |
| Isotype | IgG1κ |
| SpeciesReactivity | |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneisamemberofthecadherinsuperfamilyofgenes,encodingcalcium-dependentintercellularadhesionglycoproteins.Cadherinsconsistofanextracellulardomaincontaining5cadherindomains,atransmembraneregion,andaconservedcytoplasmicdomain.Transcriptsfromthisparticularcadherinareexpressedinmyoblastsandupregulatedinmyotubule-formingcells.Theproteinisthoughttobeessentialforthecontrolofmorphogeneticprocesses,specificallymyogenesis,andmayprovideatriggerforterminalmusclecelldifferentiation. |
| GeneSymbol | - CDH15
- CDH3
- myotubule-cadherin
- cadherin-14
- Muscle-cadherin
- CDHM
- cadherin-3
- muscle-cadherin
- Cadherin-14
- M-cadherin
- CDH14
- MCAD
|
| PurificationMethod | Thiophilicadsorptionandsizeexclusion |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P55291#Cadherinsarecalciumdependentcelladhesionproteins.Theypreferentiallyinteractwiththemselvesinahomophilicmannerinconnectingcells;cadherinsmaythuscontributetothesortingofheterogeneouscelltypes.M-cadherinispartofthemyogenicprogramandmayprovideatriggerforterminalmuscledifferentiation. SIZE:814aminoacids;88916Da SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein. SIMILARITY:SwissProt:P55291##Contains5cadherindomains. |
| MolecularWeight | Mr130kDa |