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    當前位置 ： Millipore >>> Millipore/05-797R | Anti-phospho-Erk1/2 (Thr202/Tyr204, Thr185/Tyr187)Antibody, recombinant clone AW39R, rabbit monoclon
    Millipore/05-797R | Anti-phospho-Erk1/2 (Thr202/Tyr204, Thr185/Tyr187)Antibody, recombinant clone AW39R, rabbit monoclon
    • Millipore/05-797R | Anti-phospho-Erk1/2 (Thr202/Tyr204, Thr185/Tyr187)Antibody, recombinant clone AW39R, rabbit monoclon

    Millipore/05-797R | Anti-phospho-Erk1/2 (Thr202/Tyr204, Thr185/Tyr187)Antibody, recombinant clone AW39R, rabbit monoclon

    價格: ￥4188.00 市場價: 6980.00
    打印產品信息
    貨號: 05-797R
    品牌: Millipore
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      • Description
        CatalogueNumber05-797R
        Replaces05-797
        BrandFamilyUpstate
        TradeName
        • Upstate
        DescriptionAnti-phospho-Erk1/2(Thr202/Tyr204,Thr185/Tyr187)Antibody,recombinantcloneAW39R,rabbitmonoclonal
        AlternateNames
        • Erk1
        • Erk2
        • p44-MAPK
        • p42-MAPK
        • MAPK2
        • PRKM2
        • p41mapk
        • PRKM1
        • p44
        • ERK2
        • P42MAPK
        • ERK
        • p42
        • MAPK1
        • ERT1
        • ERT2
        • Mitogen-activatedproteinkinase
        • MAPKinase2
        • MAPKianse1
        • MAPK
        BackgroundInformationErk(Extracellularsignal-RelatedKinase)isafamilyoftwo,highlyhomologousproteinsdenotedasErk1(p44,MAPK3)andErk2(p42,MAPK1)thatbothfunctioninthesamepathway.ThetwoproteinsareoftenreferredtocollectivelyasErk1/2orp44/p42MAPkinase.TheErkpathwayisconsideredtheclassical,canonicalMAPK(Mitogen-ActivatedProteinKinase)signalingpathway.Itisanevolutionarilyconservedpathwaythatcontrolsandisacriticalregulatorofthegrowthandsurvivalthroughthepromotionofcellproliferationandthepreventionofapoptosis.Erkisinvolvedinthecontrolofmanyfundamentalcellularprocessesincludingcellproliferation,survival,differentiation,apoptosis,motilityandmetabolism.Erkisactivatedbygrowthfactorstimulationofreceptortyrosinekinases(RTKs),GPCR,and/orintegrinstimulation.ThisactivatestheRas-Raf-MEK-Erkpathwaythatresultsinthephosphorylation/activationofErk1/2(p44/p42)ontheTxYmotif(Thr202/Tyr204andThr185/Tyr187forErk1&Erk2,respectively).
        ProductInformation
        FormatPurified
        Control
        • PDGF-treatedNIH/3T3celllysates
        PresentationProteinAPurifiedimmunoglobulinin30%glycerol,0.07MTris-glycine,pH7.4,0.105MNaCl,0.035%sodiumazideasapreservative.
        StorageandShippingInformation
        StorageConditionsStablefor1yearat-20°Cfromdateofreceipt.HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
        Applications
        ApplicationAnti-phospho-Erk1/2(Thr202/Tyr204Antibody,Thr185/Tyr187),recombinantcloneAW39Rdetectslevelofphospho-Erk1/2(Thr202/Tyr204&hasbeenpublished&validatedforuseinMplex&WB.
        KeyApplications
        • Multiplexing
        • WesternBlotting
        BIOLOGicalInformation
        ImmunogenPhosphorylatedpeptidecorrespondingtoaminoacidssurroundingthepTEpYmotifintheactivationloopofhumanphospho-Erk1/2,inwhichtheThrandTyrresiduesarephosphorylated
        EpitopepTEpYintheactivationloop
        CloneAW39R
        HostRabbit
        SpecificityRecognizesErk1&2onlywhenduallyphosphorylatedonitsTxYactivationmotif.
        IsotypeIgG
        SpeciesReactivity
        • Human
        • Mouse
        • Rat
        AntibodyTypeMonoclonalAntibody
        EntrezGeneNumber
        EntrezGeneSummaryTheproteinencodedbythisgeneisamemberoftheMAPkinasefamily.MAPkinases,alsoknownasextracellularsignal-regulatedkinases(ERKs),actasanintegrationpointformultiplebiochemicalsignals,andareinvolvedinawidevarietyofcellularprocessessuchasproliferation,differentiation,transcriptionregulationanddevelopment.Theactivationofthiskinaserequiresitsphosphorylationbyupstreamkinases.Uponactivation,thiskinasetranslocatestothenucleusofthestimulatedcells,whereitphosphorylatesnucleartargets.Twoalternativelysplicedtranscriptvariantsencodingthesameprotein,butdifferingintheUTRs,havebeenreportedforthisgene.
        GeneSymbol
        • Erk1
        • Erk2
        • p44-MAPK
        • p42-MAPK
        • MAPK2
        • PRKM2
        • p41mapk
        • PRKM1
        • p44
        • ERK2
        • P42MAPK
        • ERK
        • p42
        • MAPK1
        • ERT1
        • ERT2
        • Mitogen-activatedproteinkinase
        • MAPKinase2
        • MAPKianse1
        • MAPK
        Modifications
        • Phosphorylation
        PurificationMethodProteinAPurfied
        UniProtNumber
        UniProtSummaryFUNCTION:SwissProt:P28482#Involvedinboththeinitiationandregulationofmeiosis,mitosis,andpostmitoticfunctionsindifferentiatedcellsbyphosphorylatinganumberoftranscriptionfactorssuchasELK1.PhosphorylatesEIF4EBP1;requiredforinitiationoftranslation.Phosphorylatesmicrotubule-associatedprotein2(MAP2).PhosphorylatesSPZ1(Bysimilarity).Phosphorylatesheatshockfactorprotein4(HSF4).
        COFACTOR:Magnesium(Bysimilarity).
        SIZE:360aminoacids;41390Da
        SUBUNIT:InteractswithMORG1(Bysimilarity).BindstoHIV-1NefthroughitsSH3domain.Thisinteractioninhibitsitstyrosine-kinaseactivity.InteractswithHSF4.
        DOMAIN:SwissProt:P28482TheTXYmotifcontainsthethreonineandtyrosineresidueswhosephosphorylationactivatestheMAPkinases.
        PTM:DuallyphosphorylatedonThr-185andTyr-187,whichactivatestheenzyme.
        SIMILARITY:Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.MAPkinasesubfamily.&Contains1proteinkinasedomain.
        MolecularWeightErk1(p44)(~44kDa)andErk2(p42)(~42kDa).
        PhysicochemicalInformation
        Dimensions
        MaterialsInformation
        MaterialsInformation
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