當前位置： Millipore >>> Millipore/05-413 | Anti-phospho-GSK3 (Tyr279/Tyr216) Antibody, clone 5G-2F/05-413/200 µg

Millipore/05-413 | Anti-phospho-GSK3 (Tyr279/Tyr216) Antibody, clone 5G-2F/05-413/200 µg

價格: ￥4068.00 市場價: 6780.00

打印產品信息

貨號: 05-413

品牌: Millipore

規格

默認

數量

庫存(0)

特別提示

代購產品：無質量問題不接受退換貨，下單前請仔細核對信息。
下單后請及時聯系客服核對商品價格，訂單生效后再付款。

立即購買加入購物車

收藏商品

資深產品顧問

咨詢顧問

全國免費服務熱線

4000-520-616

自營商城一站式服務
廠家直采剔除溢價
品質甄選正品保證
嚴控流程只做188精品
極速物流如約送貨

詳情
使用說明
常見問題

Description
CatalogueNumber	05-413
BrandFamily	Upstate
TradeName	Upstate
Description	Anti-phospho-GSK3(Tyr279/Tyr216)Antibody,clone5G-2F
AlternateNames	GSK-3alpha glycogensynthasekinase3alpha
BackgroundInformation	Glycogensynthasekinase3(GSK3)isaprolinedirectedserinethreoninekinasethatwasinitiallyidentifiedasaphosphorylatingandinactivatingglycogensynthase,akeyenzymeinglycogenmetabolism.Sincethen,ithasbeenshowntobeinvolvedintheregulationofadiversearrayofcellularfunctions,includingproteinsynthesis,cellproliferation,celldifferentiation,microtubuleassembly/disassembly,andapoptosis. ThereexiststwoisoformsofGSK3,alphaandbeta,andtheyshowahighdegreeofaminoacidhomology.ThetwoisoformsofGSK3arestrictlyregulatedviaphosphorylation.ActivationofGSK3betaisdependentuponthephosphorylationofTyr216(Tyr279inGSK3alpha).Uponactivation,ithasbeenshowntophosphorylateanumberofdifferentcellularproteins,includingp53,c-Myc,c-Jun,heatshockfactor1(HSF1),andcyclinD1

ProductInformation
Format	Purified
Control	Jurkatcelllysate,orserumstarve3T3-L1cellsfor3hours,thenstimulatewith100nMinsulinor100ng/mLIGF1for5min. IncludedPositiveAntigenControl:Catalog#12-303,Jurkatlysate.Add2.5μLof2-mercaptoethanol/100μLoflysateandboilfor5minutestoreducethepreparation.Load20μgofreducedlysateperlaneforminigels.
Presentation	PurifiedmousemonoclonalIgG1κinbuffercontaining0.1MTris-glycine,pH7.4,0.15MNaCl,0.05%sodiumazide.Frozenat-20oC.

StorageandShippingInformation
StorageConditions	Stablefor1yearat-20°Cfromdateofreceipt. HandlingRecommendations: Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20oC.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.

Applications
Application	ThisAnti-phospho-GSK3(Tyr279/Tyr216)Antibody,clone5G-2FisvalidatedforuseinWBforthedetectionofphospho-GSK3(Tyr279/Tyr216).
KeyApplications	WesternBlotting
ApplicationsNotRecommended	Immunoprecipitation

BIOLOGicalInformation
Immunogen	Syntheticpeptide(C-KQLLHGEPNVS[pY]ICSRY)correspondingtoaminoacids203-219derivedfromaregionofthecatalyticdomain(betweensuBDomainVIIandVIII)oftheDrosophilaGSK3/shaggyenzymecoupledtoovalbumin.
Epitope	SurroundingpTyr214(DrosophilaGSK-3),pTyr279(humanGSK3α),pTyr216(humanGSK3β)
Clone	5G-2F
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Mouse
Specificity	RecognizesGSK-3phosphorylatedatthetargettyrosineresidue(humanGSK-3αpY279andGSK-3βpY216).The17-aminoacidimmunogenpeptidesequencediffersfromthecorrespondinghuman,mouse,andratsequencebyonlytwoaminoacidresidues.
Isotype	IgG1κ
SpeciesReactivity	Human Mouse Rat
SpeciesReactivityNote	Human,mouse,andrat.PredictedtoreactwithGSK-3orthologsfromdrosophilamelanogasterandmanyotherspeciesbasedonsequencehomologysurroundingthetargetphosphotyrosineresidue.
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NP_476715.1
EntrezGeneSummary	Glycogensynthasekinase3-alpha(GSK3A;EC{2.7.1.37})isamultifunctionalproteinserinekinase,homologoustoDrosophila"shaggy"(zeste-white3)andimplicatedinthecontrolofseveralregulatoryproteinsincludingglycogensynthase(seeGYS1,{138570})andtranscriptionfactors(e.g.,JUN,{165160}).ItalsoplaysaroleintheWNT({164820})andPI3K(seePIK3CG,{601232})signalingpathways(seereviewby{1:Alietal.(2001)}).[suppliedbyOMIM]
GeneSymbol	gskt CG31003
Modifications	Phosphorylation
PurificationMethod	ProteinGChromatography
UniProtNumber	P83101
UniProtSummary	FUNCTION:SwissProt:P49840#Implicatedinthehormonalcontrolofseveralregulatoryproteinsincludingglycogensynthase,MYBandthetranscriptionfactorJUN(Bysimilarity). SIZE:483aminoacids;50981Da SUBUNIT:Monomer(Bysimilarity). SIMILARITY:SwissProt:P49840##Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.GSK-3subfamily.&Contains1proteinkinasedomain.
MolecularWeight	51kDa(alpha)and46kDa(beta)

PhysicochemicalInformation

Dimensions

MaterialsInformation

MaterialsInformation

售后保障

螞蟻淘生物188，秉承螞蟻淘一貫的嚴謹態度，由螞蟻淘公司專業人員負責品控、采購、物流、銷售、售后，保障正品優質。以“快速好省，為科研提供好產品、好價格”為理念，直接鏈接原廠家，從全國各地原制造商嚴格挑選188款科研精品，剔除品牌溢價，188生物新電商，把好的產品帶給科研！? 力求給你最優質的商品。

Q：生物188產品正品保障嗎？
A：生物188質量把控人員具有十年的從業經驗，在業界享有良好的口碑；自營商城，直接從廠家采購，自己的團隊負責國際物流和清關，中間沒有第三方，所有流程嚴格把控，100%保證正品，假一罰十。

Q：下單后可以修改訂單嗎？
A：下單后的商品付款之前可以修改；訂單付款成功，需要聯系我們客服進行修改；客服電話：4000-520-616

Q：可以開發票嗎？
A：本網站所售商品都是正規清關，均開具16%正規發票，發票金額含配送費金額，另有說明的除外。

Q：商品幾天可以發貨？
A：生物188商品，全部現貨銷售，付款后即可發貨,一般一周內送達！

Q：如何聯系商家？
A：有任何問題夠可以電話咨詢我們，全國24小時免費服務熱線：4000-520-616 或聯系我們的在線客服QQ：1570468124

Q：收到的商品少了/發錯了怎么辦？
A：同個訂單購買多個商品可能會分為一個以上包裹發出，可能不會同時送達，建議查看訂單詳情是否是部分發貨狀態；如未收到，可聯系在線客服或者致電4000-520-616。

Q：退換貨/維修需要多長時間？
A：一般情況下，退貨處理周期為客戶收到產品一個月內（以快遞公司顯示簽收時間為準），包裝規格、數量、品種不符，外觀毀損、短缺或缺陷，請在收到貨24小時內申請退換貨；特殊商品以合同條款為準。

24小時熱銷榜

Jackson/Peroxidase AffiniPure Goat Anti-Mouse IgG (H+L)/2.0 ml/115-035-003
￥830.00
Jackson/Peroxidase AffiniPure Goat Anti-Rabbit IgG (H+L)/2.0 ml/111-035-003
￥830.00
Qubit? dsDNA BR Assay Kit Q32853現貨
￥2000.00
Parafilm M封口膜/PM996/4x125/整箱
￥1296.00

Millipore/05-413 | Anti-phospho-GSK3 (Tyr279/Tyr216) Antibody, clone 5G-2F/05-413/200 µg

客戶服務

何為188

關注188微信公眾號